Improving the Therapy of Arvi-Associated Acute Obstructive Bronchitis in Young Children

Purpose. To assess the efficacy and safety of the use of the immunomodulator polyoxidonium in preschool children with obstructive bronchitis. Material and methods. The study included 35 children, who, based on anamnesis, clinical, laboratory and instrumental examination methods, were diagnosed with obstructive bronchitis. The age of the examined children ranged from 3 to 6 years. The control group consisted of 11 healthy children. The material for obtaining immunological data in children was peripheral venous blood. In order to analyze immunological changes, the content of B-lymphocytes and immunoglobulins in the blood was studied. The investigated immunological data included 6 indicators. The content of immunoglobulins was determined by enzyme immunoassay according to the attached instructions. Statistical analysis of the revealed data was carried out using the Wilcoxon test using the Statistica 6.0 software. All children underwent dynamic laboratory examination and immunological parameters. The primary examination was carried out when the children were admitted to the hospital. Re-examination was carried out after the end of therapy. Group I (n = 19) included patients who received treatment according to the classical scheme. Group II children (n = 16) underwent complex therapy with an immunomodulator. The drug polyoxidonium was selected as the study drug. Results. The data obtained reflect the effectiveness of the use of the immunomodulator polyoxidonium in the complex therapy of obstructive bronchitis in children. Conclusion. Immunological data obtained during the initial examination reflect the development of dysfunction of the immune system in children. It was revealed that polyoxidonium has an immunotropic effect, this is verified by the optimization of the parameters of the humoral link of the immune system.

Application of the Immunomodulator in Children With Obstructive Bronchitis

Кайтмазова

2020

Immunotherapy in Children With Obstructive Bronchitis

Кайтмазова

2020

The great interest of researchers in respiratory pathology in children is due to the high incidence rate. Respiratory diseases are most common in children attending organized preschool groups. Goal. To study the effectiveness and safety of using Derinat in the treatment of children with obstructive bronchitis. Material and methods. There were 48 children under supervision. Determination of CD-cells was carried out using CD-typing of leukocytes (using monoclonal antibodies). Statistical analysis was performed using the Wilcoxon test (Statistica 6.0 software). All children underwent dynamic laboratory examination and immunological parameters. The primary examination was carried out when the children were admitted to the hospital. Re-examination was carried out after the end of therapy. Group I (n = 19) included patients who received traditional treatment. Group II children (n = 16) underwent complex therapy with an immunomodulator. Derinat was selected as the study drug. Results. The data obtained reflect the effectiveness of the use of the drug polyoxidonium in the treatment of obstructive bronchitis in children. Conclusion. Thus, the results obtained have confirmed the effectiveness of Derinat in the treatment of children aged 3–6 years with obstructive bronchitis.

Improving the Tactics of Treatment of Obstructive Bronchitis in Children Aged 1 to 3 Years With the Use of Immunomodulators

N.K.

2021

Introduction. Bronchopulmonary pathology occupies an important place in the structure of childhood morbidity. The issues of prevention, diagnosis and treatment in children with respiratory pathology are currently relevant. Obstructive bronchitis is a common condition in childhood. The significant prevalence of obstructive bronchitis among children is due to disorders in the immune system. Scientists are currently paying much attention to the study of the functioning of the immune system in children with bronchopulmonary pathology. In addition, clinicians are studying the effect of drugs on the activity of immunocompetent cells. The aggressive action of environmental factors, the pathological action of infectious pathogens can contribute to the severe course of the disease, as well as the development of complications. In this work, we studied the effect of immunomodulators on the activity of lysozyme and on the level of circulating immune complexes. Target. Study of the effectiveness of immunomodulators in the complex treatment of obstructive bronchitis in children. Material and methods. Immunomodulators were administered to 26 children aged 1 to 3 years with a diagnosis of obstructive bronchitis. The control group included 11 healthy children. Results. The data obtained reflect the effectiveness of the use of immunomodulators in the treatment of obstructive bronchitis in children. A comparative analysis of treatment with the use of immunomodulators and treatment according to the standard scheme was carried out. There were no side effects when using immunomodulators. Conclusion. Immunological data obtained during the initial examination reflect dysfunction of the immune system. Derinat and polyoxidonium help to optimize the parameters of the immune system. The data obtained in this study made it possible to recommend prescribing the immunomodulators Derinat and Polyoxidonium to children with obstructive bronchitis.