Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications

Zhang, Baojie; Deng, Chao; Dekker, Frank J.; Quax, Wim J.

doi:10.20517/cdr.2020.58

Cited by 4 publications

(3 citation statements)

References 123 publications

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“…Mutations in the TRAIL signaling pathway confers drug resistance and reduces apoptosis in various tumors [30]. In fact, TRAIL driven signaling holds many opportunities and strategies to the development of suitable therapeutics that can trigger apoptosis in TRAIL-resistance tumors [31]. Investigations have revealed possible proapoptotic and anti-apoptotic proteins that regulate the TRAIL pathway and could be implemented as possible drug intervention strategies that can help in targeting anti-apoptotic proteins [32].…”

Section: Trail Pathway Modulation By Apigeninmentioning

confidence: 99%

Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Javed

Sadia

Iqbal³

et al. 2021

Cancer Cell Int

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Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with minimum adverse effects. In pursuit of effective strategy, a wide variety of natural products-derived compounds have been addressed for their anticancer effects. Apigenin is a naturally-occurring flavonoid present abundantly in various fruits and vegetables. Decades of research have delineated the pharmacological and biological properties of apigenin. Specifically, the apigenin-mediated anticancer activities have been documented in various types of cancer, but the generalized scientific evidence encompassing various molecular interactions and processes, such as regulation of the apoptotic machinery, aberrant cell signaling and oncogenic protein network have not been comprehensively covered. In this sense, in this review we have attempted to focus on the apigenin-mediated regulation of oncogenic pathways in various cancers. We have also addressed the cutting-edge research which has unveiled the remarkable abilities of apigenin to interact with microRNAs to modulate key cellular processes, with special emphasis on the nano-formulations of apigenin that can help their targeted delivery and can be a therapeutic solution for the treatment of various cancers.

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Section: Trail Pathway Modulation By Apigeninmentioning

confidence: 99%

Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Javed

Sadia

Iqbal³

et al. 2021

Cancer Cell Int

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“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) subfamily, and has attracted substantial attention since it induces apoptosis in tumor cells with nontoxicity towards normal cells (Zhang et al, 2020). As a promising candidate for cancer therapy, TRAIL mainly activates extrinsic apoptotic cell death through interaction with proapoptotic death receptor 4 (DR4) and/or death receptor 5 (DR5).…”

Section: Introductionmentioning

confidence: 99%

Daurisoline inhibits proliferation, induces apoptosis, and enhances TRAIL sensitivity of breast cancer cells by upregulating DR5

Liu,

Wang,

Duan

et al. 2024

Cell Biology International

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Daurisoline (DS) is an isoquinoline alkaloid that exerts anticancer activities in various cancer cells. However, the underlying mechanisms through which DS affects the survival of breast cancer cells remain poorly understood. Therefore, the present study was undertaken to investigate the potential anticancer effect of DS on breast cancer cells and reveal the mechanism underlying the enhanced tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐mediated apoptosis by DS. Cell counting kit‐8 (CCK‐8) and 5‐ethynyl‐2‐deoxyuridine (EdU) assay were used to evaluate the ability of cell proliferation. Flow cytometry was selected to examine the cell cycle distribution. TUNEL assay was used to detect the cell apoptosis. The protein expression was measured by Western blot analysis. DS was found to reduce the cell viability and suppress the proliferation of MCF‐7 and MDA‐MB‐231 cells by causing G1 phase cell cycle arrest. DS could trigger apoptosis by promoting the cleavage of caspase‐8 and PARP. The phosphorylation of ERK, JNK, and p38MAPK was upregulated clearly following DS treatment. Notably, SP600125 (JNK inhibitor) pretreatment significantly abrogated DS‐induced PARP cleavage. DS inactivated Akt/mTOR and Wnt/β‐catenin signaling pathway and upregulated the expression of ER stress‐related proteins. Additionally, DS amplified TRAIL‐caused viability reduction and apoptosis in breast cancer cells. Mechanismly, DS upregulated the protein level of DR4 and DR5, and knockdown of DR5 attenuated the cotreatment‐induced cleavage of PARP. Inhibition of JNK could block DS‐induced upregulation of DR5. This study provides valuable insights into the mechanisms of DS inhibiting cell proliferation, triggering apoptosis, and enhancing TRAIL sensitivity of breast cancer cells.

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“…Histone post-translational modifications play an important role in regulating transcription [1]. These processes include methylation, acetylation, phosphorylation, sulfonylation, and ubiquitination [2].…”

Section: Introductionmentioning

confidence: 99%

Histone Acetyltransferase Rtt109 Regulates Development, Morphogenesis, and Citrinin Biosynthesis in Monascus purpureus

Shi

Gong

Luo

et al. 2023

JoF

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Histone acetyltransferase (HAT) has been reported to be pivotal for various physiological processes in many fungi. However, the functions that HAT Rtt109 perform in edible fungi Monascus and the underlying mechanism remains unclear. Here, we identified the rtt109 gene in Monascus, constructed the rtt109 knockout strain (Δrtt109) and its complementary strain (Δrtt109:com) by CRISPR/Cas9 methods, and functionally characterized the roles that Rtt109 play in Monascus. Deletion of rtt109 significantly reduced conidia formation and colony growth, whereas, it increased the yield of Monascus pigments (MPs) and citrinin (CTN). Further real-time quantitative PCR (RT-qPCR) analysis indicated that Rtt109 remarkably affected the transcriptional expression of key genes related to development, morphogenesis, and secondary metabolism of Monascus. Together, our results revealed the critical roles of HAT Rtt109 in Monascus, and enriched our current knowledge of the development and regulation of secondary metabolism in fungi, throwing light on restraining or eliminating citrinin in the development and industrial applications of Monascus.

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Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications

Cited by 4 publications

References 123 publications

Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Daurisoline inhibits proliferation, induces apoptosis, and enhances TRAIL sensitivity of breast cancer cells by upregulating DR5

Histone Acetyltransferase Rtt109 Regulates Development, Morphogenesis, and Citrinin Biosynthesis in Monascus purpureus

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