Impulse oscillometry in acute and stable asthmatic children: a comparison with spirometry

Abstract

IOS has shown a highly significant association with spirometric indices and reversibility testing. It may be a substitute for spirometry in children who fail to perform forced expiratory maneuvers.

The case for impulse oscillometry in the management of asthma in children and adults

“…Low frequency resistance R5 was selected since it is thought to reflect the caliber of PAW and is commonly used to define a positive BDR. Six pediatric (34-36; 66-68) studies, and 1 adult (30) study reporting the mean and standard deviation (SD) BDR, were analyzed. The 95% upper limit (95% CI) was calculated from the mean + 1.96 residual SD.…”

“…In studies utilizing both IOS and spirometry, IOS has been shown to be more useful than spirometry in children in differentiating asthma from normal cohorts, particularly utilizing the BDR decrease in R5 or R10 of 20% in preschool children, (77, 78) and 8.6% in school age children (66) . IOS also proved more diagnostic in identifying uncontrolled asthmatic patients utilizing baseline values (25, 36) . These studies suggest that in children IOS detection of PAI may be more reflective of an earlier event than central airway pathology in asthma identified by spirometry.…”

Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes

“…Impedance outcomes have previously been compared using ROC analysis in children with asthma by Shi et al Here, in correspondence with our results, Fres was shown to have a high AUC at baseline prior to bronchodilator use, though AX and resistance were found to be better outcomes at detecting controlled vs uncontrolled asthma. Similar results using impulse oscillometry were observed by Batmaz et al, who showed both AX and Fres could identify controlled versus uncontrolled asthma and differentiate both forms from healthy controls . While asthma control was not analyzed in our study, it must be noted that all participants in the asthma group were being treated with inhaled corticosteroids to manage their symptoms, which may have dampened the differences from the control group.…”

“…Similarly, the impact of salmeterol on baseline lung function can not be excluded despite being withheld on the day of measurement. However, Fres has been shown to be altered in both controlled and uncontrolled asthma, with differences from healthy controls greater in uncontrolled asthma . Finally, although we only examined the ability of FOT outcomes to identify asthma from healthy controls, others have suggested that Fres may be able to predict a 10% change in FEV1, further supporting the suggestion of Fres displaying strong clinical relevance in young children with asthma.…”

The Biomarker Salivary SP-D May Indicate Small Airway Inflammation and Asthma Exacerbation

“…Unlike spirometry, FOT does not require active cooperation or forced respiratory maneuvers and is thus more suitable for young children. FOT has been shown to be more sensitive than spirometry in identifying disturbances of peripheral airway function and has been successfully used for the assessment of pulmonary function in children who cannot perform spirometry during asthma attacks [7][8][9]. However, various factors, including age, sex, height, and weight, are known to influence FOT parameters [10][11][12][13].…”