Impulsivity related to brain serotonin transporter binding capacity in suicide attempters

Lindström, Mats; Ryding, Erik; Bosson, Peter; Ahnlide, Jan-Anders; Rosén, Ingmar; Träskman‐Bendz, Lil

doi:10.1016/j.euroneuro.2003.11.001

Cited by 76 publications

(25 citation statements)

References 17 publications

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“…The relationship between depression and impulsivity is not well understood. However, there are some pieces of evidence to suggest that low levels of the serotonin transporter 5-HTT are associated with both impulsivity and depressive disorder among suicide attempters (Lindstrom et al, 2004). At least one study on MDMA reported that users scored significantly higher on a measure of mood disturbance as compared with control subjects (Morgan, 1998).…”

Section: Discussionmentioning

confidence: 98%

Impulsivity and methamphetamine use

Semple¹,

Zians²,

Grant³

et al. 2005

Journal of Substance Abuse Treatment

110

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Section: Discussionmentioning

confidence: 98%

Impulsivity and methamphetamine use

Semple¹,

Zians²,

Grant³

et al. 2005

Journal of Substance Abuse Treatment

110

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“…For example, impulsivity is thought to play a role in several psychopathologies, including ADHD and impulsive suicidal behavior. In some studies, impulsivity was found to be associated with lower SERT binding (Lindströ m et al 2004 ;Ryding et al 2006) and higher DAT availability (Tiihonen et al 1997) whereas another study found associations in the opposite direction (Koch et al 2007). Similarly, SERT alterations have often been reported in mood disorders (Ichimiya et al 2002 ;Meyer et al 2004 ;Parsey et al 2006).…”

Section: Introductionmentioning

confidence: 96%

Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects

et al. 2010

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Robust negative findings for striatal DAT availability seriously question earlier findings of positive associations between DAT availability and cognitive functions in healthy subjects. Our results also suggest that subcortical SERT availability is not associated with the neuropsychological functions and personality traits assessed. In summary, the present study suggests that neuropsychological and personality measurements in young healthy people are not associated with subcortical SERT or striatal DAT availabilities in the brain.

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“…This supports previous observations showing that biochemical findings in BPD patients were attributed to aggression scores, impulsiveness and irritability. 8,10 Serotonergic dysfunction has also been shown in other psychiatric patient populations, such as suicidal patients 14,42 and patients with violent or aggressive behaviour. 12,13,43 In light of these findings, the higher radiotracer binding to the SERT in our patients probably reflects the level of impulsiveness as a common feature in several psychiatric disorders rather than representing a factor specific for BPD.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11] In recent years, neuroimaging studies with single photon emission computed tomography (SPECT) or positron emission tomography (PET) and serotonergic radioligands have been performed in subjects with impulsive behaviour to directly assess brain serotonergic parameters, such as pre-or postsynaptic serotonin transporters (SERT) or serotonin receptors. [12][13][14] Until recently, the possibilities in imaging the SERT with SPECT in the living human brain were limited because of the lack of highly selective SERT radioligands. [I-123]β-CIT used so far for imaging the SERT also binds to the dopamine transporter with high affinity.…”

Section: Introductionmentioning

confidence: 99%

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

Schaaff¹,

Koch²,

Pöpperl³

et al. 2007

Pharmacopsychiatry

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Objective: Serotonergic dysfunction is considered to be involved in the pathophysiology of borderline personality disorder (BPD). The aim of this study was to investigate serotonin transporter availability in patients with BPD as a marker of the central serotonergic system. Methods: Eight unmedicated patients with BPD and 9 healthy control subjects received single photon emission computed tomography (SPECT) 4 hours after injection of 185 MBq [I-123] . As a measure of brain serotonin transporter (SERT) availability, ratios of specific-to-nonspecific [I-123] ADAM binding for the brainstem and hypothalamus were calculated with an occipital reference. Levels of impulsiveness and depressive symptoms were assessed with the Barratt Impulsiveness Scale and the Beck Depression Inventory. Results: Mean specific-to-nonspecific ratios showed a 43% higher brainstem and a 12% higher hypothalamus ADAM binding in patients, compared with control subjects. We found significant correlations of ADAM binding with both age and impulsiveness but not depression. Associations of BIS scores with ADAM binding remained significant after controlling for age and depression (r = 0.69, p < 0.01). Conclusion: The study provides evidence of a serotonergic dysfunction in patients with BPD and suggests a serotonergic component in the pathophysiology of the disorder. SERT binding reflected the level of impulsiveness as a common feature in BPD.Objectif : On considère que le dysfonctionnement sérotoninergique joue un rôle dans la pathophysiologie du trouble de personnalité limite (TPL). Cette étude visait à étudier, chez les patients atteints d'un TPL, la disponibilité du transporteur de la sérotonine comme marqueur du système sérotoninergique central. Méthodes : Huit patients atteints d'un TPL qui ne prenaient pas de médicament et neuf sujets témoins en bonne santé ont été soumis à une tomographie d'émission monophotonique (TEM) 4 heures après avoir reçu par injection 185 MBq [I-123] ). Pour mesurer la disponibilité du transporteur de la séroto-nine dans le cerveau (SERT), on a calculé des ratios de fixation spécifique:non spécifique [I-123] d'ADAM dans le tronc cérébral et l'hypothalamus en utilisant un point de référence occipital. On a évalué les niveaux d'impulsivité et de symptômes dépressifs au moyen de l'échelle d'impulsivité de Barratt (EIB) et du questionnaire de dépression de Beck. Résultats : Les ratios de fixation spécifique:non spé-cifique moyens ont montré que la fixation de l'ADAM était plus élevée de 43 % dans le tronc cérébral et de 12 % dans l'hypothalamus chez les patients comparativement aux sujets témoins. Nous avons constaté des liens importants entre la fixation de l'ADAM et à la fois l'âge et l'impulsivité, mais non la dépression. Les liens entre les résultats de l'EIB et la fixation de l'ADAM sont demeurés importants compte tenu de l'âge et de la dépression (r = 0,69, p < 0,01). Conclusion : L'étude présente des preuves de dysfonctionnement séro-toninergique chez les patients atteints de TPL et indique la présence d'un élé...

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Impulsivity related to brain serotonin transporter binding capacity in suicide attempters

Cited by 76 publications

References 17 publications

Impulsivity and methamphetamine use

Impulsivity and methamphetamine use

Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

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