Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects

Burke, Sarah; Giessen, E. van der; Win, Maartje de; Schilt, Thelma; Herk, Marcel van; Brink, Wim van den; Booij, Jan

doi:10.1017/s0033291710000486

Cited by 31 publications

(20 citation statements)

References 59 publications

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“…It was linked to differences in personality traits, yielding negative associations between levels of SERT binding in different brain regions and the personality trait openness (Kalbitzer et al 2009), (but see Burke et al 2011). SERT binding in the hypothalamus was observed to be negatively associated with pain (Kupers et al 2011), while cognitive functioning was found to be positively correlated to SERT levels in right dorsolateral PFC, caudate and left ventrolateral PFC (Madsen et al 2011a).…”

Section: Transportersmentioning

confidence: 97%

Serotonin and molecular neuroimaging in humans using PET

2011

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The serotonergic system is one of the most important modulatory neurotransmitter systems in the human brain. It plays a central role in major physiological processes and is implicated in a number of psychiatric disorders. Along with the dopaminergic system, it is also one of the phylogenetically oldest human neurotransmitter systems and one of the most diverse, with 14 different receptors identified up to this day, many of whose function remains to be understood. The system's functioning is even more diverse than the number of its receptors, since each is implicated in a number of different processes. This review aims at illustrating the distribution and summarizing the main functions of the serotonin (5-hydroxytryptamin, 5-HT) receptors as well as the serotonin transporter (SERT, 5-HTT), the vesicular monoamine transporter 2, monoamine oxidase type A and 5-HT synthesis in the human brain. Recent advances in in vivo quantification of these different receptors and enzymes that are part of the serotonergic system using positron emission tomography are described.

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Section: Transportersmentioning

confidence: 97%

Serotonin and molecular neuroimaging in humans using PET

2011

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“…Dopamine is implicated in the regulation of specific personality traits [ 16 , 17 ], and dopamine transporter/receptor availability may also be associated with certain traits [ 18 , 19 ]. However, the relationship between DAT availability and personality has not been clearly established either among healthy subjects or patient populations [ 19 , 20 ]. Thus, the current study investigated striatal DAT density and its association to both cognitive functioning and specific personality traits among patients with pure AD compared with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence

et al. 2015

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Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.

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“…When concentrating on the dopamine transporter, we observed the presence of the homozygous DAT genotype 9/9 at more than 5 times greater frequency in the group of elite athletes than in controls. Allele 9 occurred more than twice more often in elite athletes than in controls (Burke et al, 2011). When comparing the 10-repeat allele with the previously mentioned one, an association occurs with increased gene expression in both in vitro (Mill et al, 2002) and in vivo (Pasini et al, 2013).…”

Section: Table 1 Frequency Of Genotypes and Alleles Of The Dat1 Gene mentioning

confidence: 73%

“…Numerous results also suggest that subcortical SERT availability shows no association with neuropsychological functions and personality traits that are assessed. Burke et al (2011) stated that neuropsychological and personality measurements in young healthy people suggested no association with subcortical SERT or striatal DAT availabilities in the brain.…”

Section: Table 1 Frequency Of Genotypes and Alleles Of The Dat1 Gene mentioning

confidence: 99%

Analysis of Polymorphic Variants of the Dopamine Transporter (DAT1) Gene Polymorphism and Personality Traits Among Athletes

Michałowska–Sawczyn

Lachowicz

Grzywacz

et al. 2020

Journal of Human Kinetics

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Personality traits, especially in sport are modulatory factors of athletes’ behavior – his/ her conscientiousness, the will to achieve an aim, perseverance and motivation of activity. Not only are biological predispositions related to anatomical or biochemical traits of success, but they are also largely determined by personality traits that result from genetic factors. In our research we joined tests of athlete’s personality in correlation with genotypes of the dopamine transporter (DAT1) gene polymorphism. The selection of this polymorphism was based on previous reports connecting the influence of dopamine with motivation and numerous arguments supporting its correlation with human behavior. We observed significant differences among polymorphisms DAT 9/9, 9/10, 10/10 in terms of proportion of particular genotypes between athletes and the control group. We also found significant differences in the NEO FFI sten scale for conscientiousness. We noticed that anxiety was related with genotypic variants of DAT1, specifically the 9/10 VNTR variant, which conditioned lower levels of anxiety in the group of tested athletes. By contrast, the lower sten value of agreeability was statistically significant for the group of athletes that were carriers of the 10/10 VNTR genotype. Heterozygous 9/10 VNTR among athletes showed lower levels of anxiety in comparison with the control group, whereas agreeability determined using the NEO FFI scale represented a lower value among athletes that had the 10/10 polymorphism. We may thus conclude that the presence of polymorphic variants of the dopamine transporter gene corresponds to athletes’ personality traits.

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Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects

Cited by 31 publications

References 59 publications

Serotonin and molecular neuroimaging in humans using PET

Serotonin and molecular neuroimaging in humans using PET

Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence

Analysis of Polymorphic Variants of the Dopamine Transporter (DAT1) Gene Polymorphism and Personality Traits Among Athletes

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