Impulsivity‐related traits distinguish women with co‐occurring bulimia nervosa in a psychiatric sample

Reas, Deborah L.; Pedersen, Geir; Rø, Øyvind

doi:10.1002/eat.22606

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…BPD presents alongside BN/BSD in approximately 35% of cases [5]. As these conditions are often comorbid they share many of the same risk factors, phenotypes, and behavioural traits including: attachment disturbances [6], adverse childhood experiences [7], non-suicidal self-injury [8], interpersonal difficulties [4, 9], and comorbid maladaptive mood and impulse regulation behaviours [10, 11]. In lieu of the large degree to which BPD interferes with interpersonal functioning, sense of self, and quality of life, it can be hypothesized that the 35% of those with BN/BSD and comorbid BPD (BN/BSD-BPD) face unique challenges.…”

Section: Introductionmentioning

confidence: 99%

Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review

McDonald

2019

Eat Weight Disord

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PurposeTo evaluate and understand the genetic and epigenetic basis of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD).MethodsThe present systematic review was conducted in accordance to PRISMA guidelines. Advanced systematic searches of Medline, EMBASE, PsychINFO, Web of Science, Scopus, CINHAL plus, and the Cochrane Library were conducted using the search terms ‘bulimia nervosa’, ‘bulimia spectrum disorder’, ‘borderline personality disorder’, ‘genes’, and ‘genetics’. The search strategy garnered seven studies for inclusion in the present review.ResultsWomen with BN/BSD-BPD had significantly lower serotonin and monoamine oxidise activity compared to women with BN/BSD or healthy controls (HC). As well, women with BN/BSD-BPD displayed elevated methylation of the dopamine receptor gene promoter, brain-derived neurotrophic factor, and changes in the methylation of the glucocorticoid receptor gene promoter (NR3C1) compared to women with BN/BSD and HC. The results also demonstrated that rates of childhood sexual abuse and childhood physical abuse are higher in those with BN/BSD-BPD than those with BN/BSD and HC, and that these types of abuse are often correlated with the methylation differences seen in BN/BSD-BPD women.ConclusionDue to the differences observed between individuals with BN/BSD-BPD and those with BN/BSD and HC a genetic/epigenetic aetiological model of BN/BSD-BPD was developed and is proposed in this review. This evidence-based model visually illustrates the current state of the field and draws attention to the need for subsequent research.Electronic supplementary materialThe online version of this article (10.1007/s40519-019-00688-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review

McDonald

2019

Eat Weight Disord

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“…Impulsivity contributes to dysfunctional behaviors such as eating disorders, Attention Deficit and Hyperactivity Disorder, psychopathy, poor job performance (O'Connor & Jackson, 2008), risky sexual behavior (Charnigo et al, 2013;Netto et al, 2016). The people with some diseases typically tend to be more impulsive (Ahn & Vassileva, 2016;Dervic et al, 2015;Evren & Bozkurt, 2017;Maraz et al, 2016;Netto et al, 2016;Reas et al, 2016;Steele et al, 2017;Tamam et al, 2017;Zhao et al, 2017), but not always. For example, low impulsivity characterizes people with oncological diseases (Manova, 2014).…”

Section: Psychological Thoughtmentioning

confidence: 99%

“…Impulsivity is not a unitary construct (Adams et al, 2012;Maraz et al, 2016), but it is a multifaceted (Evren & Bozkurt, 2017;Maccalum et al, 2007;Netto et al, 2016), multidimensional (Adams et al, 2012;Maccalum et al, 2007;Magid et al, 2007;Ramakrishnan et al, 2019), complex (Magid et al, 2007), heterogeneous (Dick et al, 2010) construct. Impulsivity is characterized by rapid, unpredictable, unplanned, spontaneous, rashly and sudden reactions to stimuli (Adams et al, 2012;Chase et al, 2017;Dick et al, 2010;Maccalum et al, 2007;Pérez Fuentes et al, 2016;Ramakrishnan et al, 2019), rapid decision-making and action (Magid et al, 2007;Patton et al, 1995), before complete processing of information, without considering all the information available (Maccalum et al, 2007;Molero Jurado et al, 2020;Pérez Fuentes et al, 2016), without adequate forethought, deliberation, premeditation or planning (Adams et al, 2012;Charnigo et al, 2013;Chase et al, 2017;Daurio et al, 2018;Dick et al, 2010;Gunn et al, 2018;Harden & Tucker-Drob, 2011;Johansen, 2014;Lynam, n.d.;Maccalum et al, 2007;Magid et al, 2007;Merchán-Clavellino et al, 2020;Molero Jurado et al, 2020;Patton et al, 1995;Ramakrishnan et al, 2019;Reas et al, 2016;…”

Section: Definitions Of Impulsivitymentioning

confidence: 99%

“…the tendency to experience strong impulses and act rashly under conditions of negative mood states, and positive urgency, i.e. the tendency towards rash actions in response to positive mood (Adams et al, 2012;Chase et al, 2017;Daurio et al, 2018;Dick et al, 2010;Gunn et al, 2018;Lynam, n.d.;Ramakrishnan et al, 2019;Reas et al, 2016;Wan et al, 2020;Whiteside & Lynam, 2001;Zhao et al, 2017), decreased sensitivity to negative consequences of behavior and decreased sensitivity to punishment (Cross et al, 2011;Maccalum et al, 2007;Merchán-Clavellino et al, 2020), decreased sensitivity to non-reward (Wan et al, 2020), preference for and sensitivity to immediate smaller reward (Chase et al, 2017;Cheng, 2020;Cross et al, 2011;Maccalum et al, 2007;Merchán-Clavellino et al, 2020;Molero Jurado et al, 2020;Pérez Fuentes et al, 2016;Wan et al, 2020), deficits in self-control, a repeated failure of self-discipline and self-regulation (Cross et al, 2011;Maccalum et al, 2007;Ramakrishnan et al, 2019;Zuckerman, 2014), lack of perseverance (Adams et al, 2012;Chase et al, 2017;Daurio et al, 2018;Dick et al, 2010;Gunn et al, 2018;Lynam, n.d.;Merchán-Clavellino et al, 2020;Ramakrishnan et al, 2019;Reas et al, 2016;Wan et al, 2020;…”

Section: Definitions Of Impulsivitymentioning

confidence: 99%

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Associations Among Functional and Dysfunctional Impulsivity: Direct and Indirect Effects on Sensation Seeking in Youth (19-25 Years Old)

Stoyanova

2021

PSYCT

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It is important to study the relationships between sensation seeking, functional and dysfunctional impulsivity to clarify the appropriateness and effectiveness of ways for seeking optimal stimulation. The aim of this study was to investigate if dysfunctional impulsivity had stronger direct and indirect effects on sensation seeking in youth with functional impulsivity as a mediator. Sensation seeking, functional and dysfunctional types of impulsivity were studied among 764 students from 19 to 25 years old by means of Radoslavova and Velichkov’s (2005) questionnaire. The results indicated that sensation seeking, functional and dysfunctional impulsivity correlated significantly and positively. Dysfunctional impulsivity was directly related to sensation seeking, as well as indirectly related to sensation seeking mediated by functional impulsivity. The findings also revealed that functional impulsivity was directly related to sensation seeking, as well as indirectly related to sensation seeking mediated by dysfunctional impulsivity. Dysfunctional impulsivity had larger direct effects on sensation seeking than functional impulsivity. Dysfunctional impulsivity also had larger effects as a mediator on sensation seeking than the effects of functional impulsivity as a mediator on sensation seeking. These findings suggest some deficiencies in the speed and accuracy of processing information, and the effectiveness of made decisions and implemented actions in search of optimal stimulation among youth.

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“…Clinical studies testing this hypothesis have not yet been reported in humans and will be needed to confirm this hypothesis. Alternatively, several studies have found that elevated rates of impulsivity and behavioral disinhibition contribute to binge-eating episodes in patients with BN and BED [2][3][4][5][6]. Psychopharmacologic studies support a role for fluoxetine and lisdexamfetamine in treating…”

Section: Introductionmentioning

confidence: 99%

Emerging Treatments in Eating Disorders

Lutter

2017

Neurotherapeutics

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Eating disorders (EDs), including anorexia nervosa, bulimia nervosa, and binge-eating disorder, constitute a class of common and deadly psychiatric disorders. While numerous studies in humans highlight the important role of neurobiological alterations in the development of ED-related behaviors, the precise neural substrate that mediates this risk is unknown. Historically, pharmacological interventions have played a limited role in the treatment of eating disorders, typically providing symptomatic relief of comorbid psychiatric issues, like depression and anxiety, in support of the standard nutritional and psychological treatments. To date there are no Food and Drug Administration-approved medications or procedures for anorexia nervosa, and only one Food and Drug Administration-approved medication each for bulimia nervosa (fluoxetine) and binge-eating disorder (lisdexamfetamine). While there is little primary interest in drug development for eating disorders, postmarket monitoring of medications and procedures approved for other indications has identified several novel treatment options for patients with eating disorders. In this review, I utilize searches of the PubMed and ClinicalTrials.gov databases to highlight emerging treatments in eating disorders.

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Impulsivity‐related traits distinguish women with co‐occurring bulimia nervosa in a psychiatric sample

Cited by 10 publications

References 26 publications

Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review

Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review

Associations Among Functional and Dysfunctional Impulsivity: Direct and Indirect Effects on Sensation Seeking in Youth (19-25 Years Old)

Emerging Treatments in Eating Disorders

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