Impurity profiling in bulk pharmaceutical batches using 19F NMR spectroscopy and distinction between monomeric and dimeric impurities by NMR-based diffusion measurements

19F diffusion NMR analysis of enzyme–inhibitor binding

“…The fluorine chemical shift range is also greater than that of 1 H, improving resolution and facilitating the measurement of free and bound species. 19 F NMR diffusion measurements have previously been used to study the binding of a fluorinated drug to albumin, 13 to characterize impurities in bulk pharmaceuticals 14 and to study liquid crystals in different phases. 15 Pancreatic elastase is a serine protease exhibiting specificity for the hydrolysis of peptide bonds on the carboxylic side of small amino acids with uncharged side-chains such as alanine and glycine.…”

Biodegradation of pharmaceuticals in membrane aerated biofilm reactor for autotrophic nitrogen removal: A model-based evaluation

“…Parameters regarding the mass transfer coefficients for ammonium, nitrite, nitrate, dinitrogen, and oxygen are adopted from Hao et al [32]. The mass transfer coefficient for PhAC is adopted from Mistry et al [33]. The mass transfer coefficient for slow biodegradable substrate derived from biomass decay is adopted from Picioreanu et al [34].…”

LC‐NMR Overview and Pharmaceutical Applications

“…In the area of natural products, LC-NMR has been applied to screen plant constituents from crude extracts [54,57,67,68] and to analyze plant and marine alkaloids [69][70][71][72], flavonoids [73], sesquiterpene lactones [74,75], saponins [58,76], vitamin E homologues [77], and antifungal and bacterial constituents [56,78,79] as examples. And finally, LC-NMR has been used for areas such degradation products [90][91][92][93], drug impurities [94][95][96][97][98][99][100][101][102], drug discovery [103,104], and food analysis [105][106][107]. And finally, LC-NMR has been used for areas such degradation products [90][91][92][93], drug impurities [94][95][96][97][98][99][100]…”