In Addition to Insulin Resistance and Obesity, Brachial-Ankle Pulse Wave Velocity is Strongly Associated with Metabolic Syndrome in Chinese - A Population-Based Study (Taichung Community Health Study, TCHS)

Lin, Wen‐Yuan; Lai, Ming-May; Li, Chia‐Ing; Lin, Cheng‐Chieh; Li, Tsai‐Chung; Chen, Ching‐Chu; Lin, Tze–Yi; Liu, Chiu-Shong

doi:10.5551/jat.e603

Cited by 28 publications

(29 citation statements)

References 29 publications

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“…Brachial-ankle PWV (BaPWV) has been shown to be an index of central arterial stiffness with a good correlation with the aortic PWV obtained by invasive recording, which has been demonstrated to have a close relationship with carotid-femoral PWV 9,11) . Previous studies have also shown that baPWV is strongly associated with cardiovascular diseases and metabolic syndrome 4,12,13) . In addition, insulin resistance has been found to be related to arterial stiffness in adolescents, in adults with metabolic syndrome, diabetes, or hypertension, and in healthy non-diabetic middleaged women 5,[14][15][16] .…”

Section: Introductionmentioning

confidence: 91%

“…Among 3530 individuals selected, 2359 agreed to participate. Thus, the overall response rate was 66.8% 13,17,20) . Subjects with an ankle-brachial index 0.9 or incomplete data for baPWV examination were excluded.…”

Section: Study Subjectsmentioning

confidence: 97%

“…Details of sampling have been described previously 13,[17][18][19] . In brief, there were 363,543 residents in this area at the time of the study, which represented about 4.09 % of the national population of the same age.…”

Section: Study Subjectsmentioning

confidence: 99%

“…The degree of arterial stiffness was represented by baPWV measurements. We have previously demonstrated that baPWV is closely associated with metabolic syndrome and proposed an optimal cut-off baPWV value for detecting cardiovascular diseases, 1540 cm/sec in men and 1480 cm/sec in women 13) ; therefore, increasing arterial stiffness was defined as baPWV values that exceeded these sex-specific thresholds.…”

Section: Arterial Stiffnessmentioning

confidence: 99%

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Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)

Lin

Hsu

et al. 2011

J Atheroscler Thromb

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Section: Introductionmentioning

confidence: 91%

Section: Study Subjectsmentioning

confidence: 97%

Section: Study Subjectsmentioning

confidence: 99%

Section: Arterial Stiffnessmentioning

confidence: 99%

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Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)

Lin

Hsu

et al. 2011

J Atheroscler Thromb

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“…Yamashina et al (2002) recently reported on the validity and reproducibility of baPWV measurements. Previous studies had proved that baPWV was associated with CVD and metabolic syndrome (MS) (Tomiyama et al, 2005;Lin et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Zhao

Song

et al. 2014

J. Zhejiang Univ. Sci. B

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Background and objective: Non-alcoholic fatty liver disease (NAFLD) is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods: A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged (20-65 years) subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results: The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls ((1321±158) cm/s vs. (1244±154) cm/s; P<0.001). The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group (29.3% vs. 16.9%; P<0.001), and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness (both P for trend <0.001). Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions: Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.

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The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan

Yang

Liu

et al. 2012

Mol Biol Rep

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Metabolic syndrome (MetS) is a combination of medical disorders, consisting of multiple, interrelated risk factors of metabolic origin. To investigate the associations of MetS with appetite-related genes (LEPR, near MC4R and SH2B1) and cholesterol metabolism-related gene (LRP5) polymorphism variants and the joint effect of cigarette smoking and these polymorphism variants on MetS in a community-based case-control study. Metabolic syndrome was defined according to the American Heart Association and National Heart Lung Blood Institute (AHA/NHLBI) criteria. A total of 237 MetS cases and 202 subjects without MetS aged 40 or over in Taiwan were analyzed. The genotypes of LRP5-rs3736228, LEPR-rs1137100, near MC4R-rs17782313 and SH2B1-rs4788102 were analyzed by the PCR-restriction fragment length polymorphism method. A strong association of the SNP rs17782313 near MC4R gene with MetS susceptibility was found. The data indicated that the C allele of near MC4R-rs17782313 is an obvious risk factor for MetS susceptibility. The joint effects of cigarette smoking and susceptible genotypes of LRP5, LEPR, near MC4R or SH2B1 genes led to a relatively higher risk of having MetS. Using subjects with the wild-type of LRP5, LEPR, near MC4R or SH2B1 genes and without a smoking habit as a reference group, those with cigarette smoking (current and former) and more than one variant type had a 4.1-fold (95 % CI = 1.6-10.2) risk of having MetS. The genotypes of the appetite-related genes (LEPR, near MC4R and SH2B1) and cholesterol metabolism-related gene (LRP5), together with a cigarette smoking habit, are important risk factors for MetS.

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In Addition to Insulin Resistance and Obesity, Brachial-Ankle Pulse Wave Velocity is Strongly Associated with Metabolic Syndrome in Chinese - A Population-Based Study (Taichung Community Health Study, TCHS)

Cited by 28 publications

References 29 publications

Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)

Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan

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In Addition to Insulin Resistance and Obesity, Brachial-Ankle Pulse Wave Velocity is Strongly Associated with Metabolic Syndrome in Chinese - A Population-Based Study (Taichung Community Health Study, TCHS)

Cited by 28 publications

References 29 publications

Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese &mdash;A Population-Based Study (Taichung Community Health Study, TCHS)

Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese &mdash;A Population-Based Study (Taichung Community Health Study, TCHS)

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan

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Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)

Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese —A Population-Based Study (Taichung Community Health Study, TCHS)