In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome

Chávez‐Gutiérrez, Edwin; Martínez-Arellanes, Matilda; Murillo-López, Montserrat; Medina-Guzmán, María Fernanda; Mobarak-Richaud, Laila; Pelcastre-Guzmán, Karen; Quintana-Romero, Osvaldo Javier; Ariza‐Castolo, Armando; Ayala-Moreno, María del Rosario; Salazar, Juan Rodrigo; Guerra‐Araiza, Christian; Rodrı́guez-Páez, Lorena; Pinto‐Almazán, Rodolfo; Loza-Mejía, Marco A.

doi:10.3390/ph15121461

Cited by 3 publications

(2 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several mechanisms have been proposed to explain the multiple bioactivities of MB components. The use of molecular docking + molecular dynamics simulation has been proven useful for the prediction or delimitation of the potential molecular mechanism of action of some molecules, particularly those of natural origin and in potential multitarget ligands [34][35][36][37][38][39][40][41].…”

Section: Effect Of Mb Administration On Oxidative Stress Markersmentioning

confidence: 99%

In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative Stress Markers in a Metabolic Syndrome Model

Castillo-García,

Cossio-Ramírez,

Córdoba-Méndez

et al. 2023

Metabolites

Self Cite

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular disease, obesity, and diabetes. In the present study, in vivo and in silico studies have been performed to evaluate the molecular mechanisms implied to improve the metabolic parameters of MetS. Fourteen-day administration of maqui berry reduces weight gain, blood fasting glucose, total blood cholesterol, triacylglycerides, insulin resistance, and blood pressure impairment in the diet-induced MetS model in male and female rats. In addition, in the serum of male and female rats, the administration of maqui berry (MB) improved the concentration of MDA, the activity of SOD, and the formation of carbonyls in the group subjected to the diet-induced MetS model. In silico studies revealed that delphinidin and its glycosylated derivatives could be ligands of some metabolic targets such as α-glucosidase, PPAR-α, and PPAR-γ, which are related to MetS parameters. The experimental results obtained in the study suggest that even at low systemic concentrations, anthocyanin glycosides and aglycones could simultaneously act on different targets related to MetS. Therefore, these molecules could be used as coadjuvants in pharmacological interventions or as templates for designing new multitarget molecules to manage patients with MetS.

show abstract

Section: Effect Of Mb Administration On Oxidative Stress Markersmentioning

confidence: 99%

In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative Stress Markers in a Metabolic Syndrome Model

Castillo-García,

Cossio-Ramírez,

Córdoba-Méndez

et al. 2023

Metabolites

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, in more advanced cases, pharmacological treatment becomes necessary. 43 There is no single drug to treat MetS. The approach must be individualized, with the management of each metabolic alteration and its associated comorbidity: statins, hypoglycemic agents, antihypertensive drugs, and antiplatelet drugs for those with increased prothrombotic risk.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

One Size Does Not Fit All: The Need to Rethink the Metabolic Syndrome in Women

Almeida,

Castro,

Espíndola

et al. 2023

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is increasing at epidemic proportions worldwide. MetS and its components are frequent among Brazilian women (41.8%). Women are affected by changes in adipose tissue distribution, lipid profile, insulin resistance (IR), and vascular remodeling during their lives. These changes result from the lack of estrogen after menopause. There have been various attempts to propose a uniform origin for the clustering of the MetS components, including genetics, IR, obesity, lifestyle, sleep disturbances, inflammation, fetal and neonatal programming, and disturbed circadian rhythm of the body functions. The proinflammatory and prothrombotic state in MetS is well-defined. Socioeconomic and lifestyle-related factors are also essential triggers of MetS, which is associated with a higher risk for coronary artery diseases (CAD) and stroke in women. Population measures in health and community medicine, such as continuing education on the importance of lifestyle change to reduce cardiovascular risks from early childhood, are fundamental strategies. Statins reduce high-sensitivity C-reactive protein blood levels and treat high cholesterol. According to the patient, hypoglycemic agents, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1(GLP-1a), and sodium-glucose transport protein 2 (SGLT2) inhibitors, in addition to metformin, have their indication due to their beneficial cardiometabolic and vascular effects. Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin-receptor blocker (ARB) should be the first choice to treat hypertension in postmenopausal womem. The recognition of the different gender-and age-specific risk factors, allowing for specific and targeted interventions, is fundamental, especially for women.

show abstract

Aminocarbonylation of 2-(N-substituted) 5-iodobenzoates: synthesis of glyoxylamido-anthranilates, their cytotoxicity and molecular modeling study

Cheremnykh,

Baev,

Nacharova

et al. 2024

Chem. Pap.

View full text Add to dashboard Cite

In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome

Cited by 3 publications

References 95 publications

In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative Stress Markers in a Metabolic Syndrome Model

In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative Stress Markers in a Metabolic Syndrome Model

One Size Does Not Fit All: The Need to Rethink the Metabolic Syndrome in Women

Aminocarbonylation of 2-(N-substituted) 5-iodobenzoates: synthesis of glyoxylamido-anthranilates, their cytotoxicity and molecular modeling study

Contact Info

Product

Resources

About