(In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study

Dias, Gabriela Froio de Araujo; Silva, Vinicius da Eira; Painelli, Vítor de Salles; Sale, Craig; Artioli, Guilherme Giannini; Gualano, Bruno; Saunders, Bryan

doi:10.1371/journal.pone.0143086

Cited by 43 publications

(50 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 in response to anaerobic exercise at altitude may have contributed to the lack of power for the effect of anaerobic exercise at altitude. Individual variations in this context may represent a previously suggested responder vs. non-responder phenomenon to intervention with NaHCO 3 supplementation [64,65] or exercise performance changes under hypoxic conditions [66,67]. Another explanation for variations in the response to anaerobic exercise at altitude may be an unfamiliar exercise pattern, such that the participants were unable to properly implement the test instructions.…”

Section: Discussionmentioning

confidence: 99%

Effects of daily ingestion of sodium bicarbonate on acid-base status and anaerobic performance during an altitude sojourn at high altitude: a randomized controlled trial

Limmer

Marées

Platen

2020

Journal of the International Society of Sports Nutrition

View full text Add to dashboard Cite

Background: The present study investigated the effects of chronic sodium bicarbonate (NaHCO 3 ) ingestion on a single bout of high-intensity exercise and on acid-base balance during 7-day high-altitude exposure. Methods: Ten recreationally active subjects participated in a pre-test at sea level and a 7-day hiking tour in the Swiss Alps up to 4554 m above sea level. Subjects received either a daily dose of 0.3 g/kg NaHCO 3 solution (n = 5) or water as a placebo (n = 5) for 7 days. Anaerobic high-intensity exercise performance was assessed using the portable tethered sprint running (PTSR) test under normoxic and hypoxic conditions (3585 m). PTSR tests assessed overall peak force, mean force, and fatigue index. Blood lactate levels and blood gas parameters were assessed preand post-PTSR. Urinary pH and blood gas parameters were further analyzed daily at rest in early morning samples under normoxic and hypoxic conditions. Results: There were no significant differences between the bicarbonate and control group in any of the PTSRrelated parameters. However, urinary pH (p = 0.003, ηp 2 = 0.458), early morning blood bicarbonate concentration (p < 0.001, ηp 2 = 0.457) and base excess (p = 0.002, ηp 2 = 0.436) were significantly higher in the bicarbonate group compared with the control group under hypoxic conditions. (Continued on next page)Conclusions: These results indicate that oral NaHCO 3 ingestion does not ameliorate the hypoxia-induced impairment in anaerobic, high-intensity exercise performance, represented by PTSR-related test parameters, under hypobaric, hypoxic conditions, but the maximal performance measurements may have been negatively affected by other factors, such as poor implementation of PTSR test instructions, pre-acclimatization, the time course of hypoxia-induced renal [HCO 3 − ] compensation, changes in the concentrations of intra-and extracellular ions others than [H + ] and [HCO 3 − ], or gastrointestinal disturbances caused by NaHCO 3 ingestion. However, chronic NaHCO 3 ingestion improves blood bicarbonate concentration and base excess at altitude, which partially represent the blood buffering capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of daily ingestion of sodium bicarbonate on acid-base status and anaerobic performance during an altitude sojourn at high altitude: a randomized controlled trial

Limmer

Marées

Platen

2020

Journal of the International Society of Sports Nutrition

View full text Add to dashboard Cite

show abstract

“…<60 s). Furthermore, responses to sodium bicarbonate appear subject to both intra- [31] and inter- [64] individual variability, at least in untrained participants. Although the performance effects of co-ingesting sodium bicarbonate and βalanine are unclear [65], several studies have investigated the effects of combined supplementation on training adaptations [66][67][68].…”

Section: Discussionmentioning

confidence: 99%

“…Sodium bicarbonate is typically consumed in a dose of 0.2 to 0.4 grams per kg of bodyweight, divided across one to three servings [16], although serial loading protocols over several days have also been used [29]. This dose should be sufficient to raise bicarbonate concentrations in the blood by 5 to 6 mmol/L and allow small changes in blood pH during sub-maximal exercise, although large interindividual variability in the response to supplementation has been reported [30][31][32]. Ingestion of sodium bicarbonate before each cycling interval training session (24 sessions over eight weeks) in recreationally-active women resulted in greater improvements in the lactate threshold (26 vs. 15%, d = 0.5) and time to fatigue (164 vs 123%, d = 1.9) compared with a placebo, even though training volume and intensity was matched between groups (Table 1) [33].…”

Section: Sodium Bicarbonatementioning

confidence: 99%

Effects of Dietary Supplements on Adaptations to Endurance Training

Rothschild

Bishop

2019

Sports Med

View full text Add to dashboard Cite

Endurance training leads to a variety of adaptations at the cellular and systemic levels that serve to minimise disruptions in whole-body homeostasis caused by exercise. These adaptations are differentially affected by training volume, training intensity, and training status, as well as by nutritional choices that can enhance or impair the response to training. A variety of supplements have been studied in the context of acute performance enhancement, but the effects of continued supplementation concurrent to endurance training programs are less well characterised. For example, supplements such as sodium bicarbonate and beta-alanine can improve endurance performance and possibly training adaptations during endurance training by affecting buffering capacity and/or allowing an increased training intensity, while antioxidants such as vitamin C and vitamin E may impair training adaptations by blunting cellular signaling but appear to have little effect on performance outcomes. Additionally, limited data suggest the potential for dietary nitrate (in the form of beetroot juice), creatine, and possibly caffeine, to further enhance endurance training adaptation. Therefore, the objective of this review is to examine the impact of dietary supplements on metabolic and physiological adaptations to endurance training. Abstract word count: 185 Word count: 6,498 Number of tables: 5 Number of figures: 4 Key Points  Many supplements have been studied in the context of acute performance enhancement, but the effects of continued supplementation concurrent to endurance training programs are less well characterised.  Supplements including sodium bicarbonate, beta-alanine, dietary nitrates, antioxidants, caffeine, and creatine have the potential to modify the adaptive response to endurance training (either positively or negatively) by affecting acidbase balance, redox status, oxidant signaling, or cumulative training load, thereby affecting the cellular signaling responses to training.

show abstract

“…36 However, it has also been shown that an almost identical increase in HCO3did not necessarily result in the same effect on performance. 37 So, an individualized supplementation strategy instead of standardized supplementation could have resulted in a substantial performance effect, although this remains to be investigated, as to date no study directly compared the effect on performance of both supplementation strategies. 36 NaHCO3 ingestion can cause GI discomfort which could interfere with performance.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Sodium Bicarbonate Supplementation on the Decline in Gross Efficiency During a 2000-m Cycling Time Trial

Voskamp¹,

Bos²,

Foster³

et al. 2020

International Journal of Sports Physiology and Performance

View full text Add to dashboard Cite

Background: Gross efficiency (GE) declines during high-intensity exercise. Increasing extracellular buffer capacity might diminish the decline in GE and thereby improve performance. Purpose: To examine if sodium bicarbonate (NaHCO3) supplementation diminishes the decline in GE during a 2000-m cycling time trial. Methods: Sixteen male cyclists and 16 female cyclists completed 4 testing sessions including a maximal incremental test, a familiarization trial, and two 2000-m GE tests. The 2000-m GE tests were performed after ingestion of either NaHCO3 supplements (0.3 g/kg body mass) or placebo supplements (amylum solani, magnesium stearate, and sunflower oil capsules). The GE tests were conducted using a double-blind, randomized, crossover design. Power output, gas exchange, and time to complete the 2000-m time trials were recorded. Capillary blood samples were analyzed for blood bicarbonate, pH, and lactate concentration. Data were analyzed using magnitude-based inference. Results: The decrement in GE found after the 2000-m time trial was possibly smaller in the male and female groups after NaHCO3 than with placebo ingestion, with the effect in both groups combined being unclear. The effect on performance was likely trivial for males (placebo 164.2 [5.0] s, NaHCO3 164.3 [5.0] s; Δ0.1; ±0.6%), unclear for females (placebo 178.6 [4.8] s, NaHCO3 178.0 [4.3] s; Δ−0.3; ±0.5%), and very likely trivial when effects were combined. Blood bicarbonate, pH, and lactate concentration were substantially elevated from rest to pretest after NaHCO3 ingestion. Conclusions: NaHCO3 supplementation results in an unclear effect on the decrease in GE during high-intensity exercise and in a very likely trivial effect on performance.

show abstract

(In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study

Cited by 43 publications

References 24 publications

Effects of daily ingestion of sodium bicarbonate on acid-base status and anaerobic performance during an altitude sojourn at high altitude: a randomized controlled trial

Effects of daily ingestion of sodium bicarbonate on acid-base status and anaerobic performance during an altitude sojourn at high altitude: a randomized controlled trial

Effects of Dietary Supplements on Adaptations to Endurance Training

The Effect of Sodium Bicarbonate Supplementation on the Decline in Gross Efficiency During a 2000-m Cycling Time Trial

Contact Info

Product

Resources

About