Insight-HXMT, the first X-ray astronomical satellite in China, aims to reveal new sources in the Galaxy and to study fundamental physics of X-ray binaries from 1 keV to 250 keV. It has three collimated telescopes, the High Energy X-ray telescope (HE), the Medium Energy X-ray telescope (ME) and the Low Energy X-ray telescope (LE). Before the launch, in-orbit backgrounds of these three telescopes had been estimated through Geant4 simulation, in order to investigate the instrument performance and the achievement of scientific goals. In this work, these simulated backgrounds are compared with in-orbit observations. Good agreement is shown for all three telescopes. For HE, 1) the deviation of the simulated background rate after two years of operation in space is ∼ 5% from the observation; 2) the total background spectrum and the relative abundance of the ∼67 keV line show long-term increases both in simulations and observations. For ME,