In-gel study of the effect of magnetic nanoparticles immobilization on their heating efficiency for application in Magnetic Fluid Hyperthermia

Avolio, Matteo; Guerrini, Andrea; Brero, Francesca; Innocenti, Claudia; Sangregorio, Claudio; Cobianchi, M.; Mariani, Manuel; Orsini, F.; Arosio, Paolo; Lascialfari, A.

doi:10.1016/j.jmmm.2018.09.111

Cited by 34 publications

(34 citation statements)

References 50 publications

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“…Also, MNPs in water-based solutions can form chain-like structures causing higher SAR but not when immobilized in a gel 10 . A similar experiment was performed by Avolio et al 42 where they used 0.5% and 2% agarose gel and reported decrease in SAR for 14 and 18 nm ferrite MNPs, however they found an almost similar SAR for 10 nm particles when compared to aqueous MNP system. Similarly, Chen et al 43 observed 47% reduction in SAR of MNPs from the original value for rigid silicon-based organic polymer.…”

Section: Resultssupporting

confidence: 63%

In vitro hyperthermic effect of magnetic fluid on cervical and breast cancer cells

Bhardwaj

Parekh

Jain

2020

Sci Rep

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Self-regulating temperature-controlled nanoparticles such as Mn–Zn ferrite nanoparticles based magnetic fluid can be a better choice for magnetic fluid hyperthermia because of its controlled regulation of hyperthermia temperature window of 43–45 °C. To test this hypothesis magnetic fluid with said properties was synthesized, and its effect on cervical and breast cancer cell death was studied. We found that the hyperthermia window of 43–45 °C was maintained for one hour at the smallest possible concentration of 0.35 mg/mL without altering the magnetic field applicator parameters. Their hyperthermic effect on HeLa and MCF7 was investigated at the magnetic field of 15.3 kA/m and frequency 330 kHz, which is close to the upper safety limit of 5 * 109 A/m s. We have tested the cytotoxicity of synthesized Mn–Zn ferrite fluid using MTT assay and the results were validated by trypan blue dye exclusion assay that provides the naked eye microscopic view of actual cell death. Since cancer cells tend to resist treatment and show re-growth, we also looked into the effect of multiple sessions hyperthermia using a 24 h window till 72 h using trypan blue assay. The multiple sessions of hyperthermia showed promising results, and it indicated that a minimum of 3 sessions, each of one-hour duration, is required for the complete killing of cancer cells. Moreover, to simulate an in vivo cellular environment, a phantom consisting of magnetic nanoparticles dispersed in 1 and 5% agarose gel was constituted and studied. These results will help to decide the magnetic fluid based hyperthermic therapeutic strategies using temperature-sensitive magnetic fluid.

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Section: Resultssupporting

confidence: 63%

In vitro hyperthermic effect of magnetic fluid on cervical and breast cancer cells

Bhardwaj

Parekh

Jain

2020

Sci Rep

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“…Néel relaxation (magnetic moment rotation) is independent of the stiffness of the medium in which magnetic particles are embedded, so it does not vary from concentration to concentration. The differences in hyperthermia efficiency between water suspensions of magnetic nanoparticles and tissue-mimicking phantoms were recently reported by Avolio et al [25]. They proved that when using smaller magnetic nanoparticles (around 10 nm in size), the obtained efficiency (expressed by the SAR value) was comparable for both water suspension and hydrogel doped with nanoparticles.…”

Section: Resultsmentioning

confidence: 53%

“…When medical usage of magnetic hyperthermia is considered, deterioration of the heating efficiency of the magnetic fluid, after being introduced into the body, should be considered. Nowadays, awareness of this fact in scientific reports is increasing [25]. Despite the low thermal effect of magnetic hyperthermia, its effectiveness can be improved.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia

et al. 2019

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During hyperthermia, magnetite nanoparticles placed in an AC magnetic field become a source of heat. It has been shown that in fluid suspensions, magnetic particles move freely and generate heat easily. However, in tissues of different mechanical properties, nanoparticle movement is limited and leads to a small temperature rise in tissue. Therefore, it is crucial to conduct magnetic hyperthermia experiments in similar conditions to the human body. The effect of tissue-mimicking phantom compressibility on the effectiveness of magnetic hyperthermia was investigated on agar phantoms. Single and cluster nanoparticles were synthesized and used as magnetic materials. The prepared magnetic materials were characterized by transmission electron microscopy (TEM), and zeta potential measurements. Results show that tissue-mimicking phantom compressibility decreases with the concentration of agar. Moreover, the lower the compressibility, the lower the thermal effect of magnetic hyperthermia. Specific absorption rate (SAR) values also proved our assumption that tissue-mimicking phantom compressibility affects magnetic losses in the alternating magnetic field (AMF).

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“…The error estimation is described in Experimental Section. The observation of reduced hyperthermic response is commonly observed in magnetic gels and is usually attributed to changes in viscosity or loss of Brownian motion, [ 41 ] which are known to suppress Brownian contributions to the hyperthermic response, and/or formulation induced particle aggregation, which should primarily suppress the Néel contribution. The observation that the bulk temperature jumps achieved for the magnetic hydrogels are proportional to concentration Figure 1D, and the SAR MNF‐G value doesn't change, is consistent with similar particle dispersion in the gels across this loading range.…”

Section: Resultsmentioning

confidence: 99%

Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels

Monks

Wychowaniec

McKiernan

et al. 2020

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Multifunctional nanocomposites that exhibit well‐defined physical properties and encode spatiotemporally controlled responses are emerging as components for advanced responsive systems, for example, in soft robotics or drug delivery. Here an example of such a system, based on simple magnetic hydrogels composed of iron oxide magnetic nanoflowers and Pluronic F127 that generates heat upon alternating magnetic field irradiation is described. Rules for heat‐induction in bulk hydrogels and the heat‐dependence on particle concentration, gel volume, and gel exposed surface area are established, and the dependence on external environmental conditions in “closed” as compared to “open” (cell culture) system, with controllable heat jumps, of ∆T 0–12°C, achieved within ≤10 min and maintained described. Furthermore the use of extrusion‐based 3D printing for manipulating the spatial distribution of heat in well‐defined printed features with spatial resolution <150 µm, sufficiently fine to be of relevance to tissue engineering, is presented. Finally, localized heat induction in printed magnetic hydrogels is demonstrated through spatiotemporally‐controlled release of molecules (in this case the dye methylene blue). The study establishes hitherto unobserved control over combined spatial and temporal induction of heat, the applications of which in developing responsive scaffold remodeling and cargo release for applications in regenerative medicine are discussed.

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In-gel study of the effect of magnetic nanoparticles immobilization on their heating efficiency for application in Magnetic Fluid Hyperthermia

Cited by 34 publications

References 50 publications

In vitro hyperthermic effect of magnetic fluid on cervical and breast cancer cells

In vitro hyperthermic effect of magnetic fluid on cervical and breast cancer cells

The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia

Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels

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