In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…For instance, NIR spectroscopy proved to be appropriate for examining the blend uniformity, content uniformity, and the tablets coating thickness [38,39]. Utilization of Raman spectroscopy also seems to be feasible for real-time monitoring of freeze-drying [40] and even real-time feedback control of continuous powder blending [41]. Furthermore, a PAT system can be particularly important and useful when tablets include ASDs since these metastable systems tend to crystallize during processing [42][43][44].…”

Pharmaceutical and Macromolecular Technologies in the Spirit of Industry 4.0

“…evaluating and ensuring quality based on process data) in pharmaceutical technology were the development of controlled downstream processing (e.g. drying, milling) [54,55]. These results, combined with flow drug chemistry, contribute towards the development of end to end pharmaceutical technology [56] with fully integrated interactive process units, the model of which is shown in Fig.…”

Kinetics Study of Cocrystal Formation Between Indomethacin and Saccharin Using High-Shear Granulation With In Situ Raman Spectroscopy

“…25,26 Process control based on process analytical technology and quality-by-design are pivotal concepts for the pharmaceutical industry to produce consistent quantities of high-quality products. 27 Nondestructive and in situ spectroscopy methods have been used to monitor and control the pharmaceutical processes, such as Raman spectroscopy, 28 near-infrared spectroscopy, 29 and so on. [30][31][32] Raman spectroscopy is known as an effective way to study bond vibrational energies in the crystal structure.…”