In Pursuit of a Gene

Glass, Bentley

doi:10.1126/science.126.3276.683

Cited by 29 publications

(10 citation statements)

References 10 publications

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“…A number of alleles are known and Glass (1957), among others, has presented a reasonable explanation of its mode of action in terms of intermediary metabolism. This leaves SU(HW)2 as the only candidate for homology with the translational suppressors found in microorganisms.…”

Section: Discussionmentioning

confidence: 99%

The Phenogenetics of A Super-Suppressor in Drosophila Melanogaster I. Phenotypic Characterization and Suppressor Efficiency

Gl¹

1970

Aust. Jnl. Of Bio. Sci.

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SummaryAn investigation of the phenotypic characteristics of the super-suppressor Bu(Hw)2 of D. melanogaster was carried out using the suppressible mutant sc1 together with the scutellar, dorsocentral, and vertical bristle systems. The effect of the suppressor was studied in a series of selection lines differing in both their sc1 and sc+ means.The suppressor was found to be highly efficient and sensitive to genetic background but insensitive to temperature, developmental rate, and heterochromatin. It would appear that Bu(Hw)2 behaves as a complete recessive in all cases but this was only established definitely for the quantifiable mutant sc1• The absence of the femalespecific characteristics of su(Hw)2 in males was found not to be due to the presence of the Y -chromosome. There was a great similarity between suppressed mutant and wildtype phenotypes which was particularly apparent in the bristle class distributions.The data are not seen as compatible with the idea that the su(Hw)2 locus is normally a structural gene for t-RNA although the possibility that the translational machinery is in some way involved is very strong.

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Section: Discussionmentioning

confidence: 99%

The Phenogenetics of A Super-Suppressor in Drosophila Melanogaster I. Phenotypic Characterization and Suppressor Efficiency

Gl¹

1970

Aust. Jnl. Of Bio. Sci.

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“…In a postscript, Goldschmidt (Goldschmidt and Piternick, 1957) discusses Glass' (1957) work on the mutant-suppressor system of "erupt" in Drosophila. He agrees with him that such systems provide a buffering mechanism that allows for a considerable amount of allelic potency variation without inevitably risking the ill effects of immediate or total phenotypic penetrance, and this without the help of multiple modifiers from the genetic "background."…”

Section: Discussionmentioning

confidence: 99%

“…The backcrosses of yelIow F 1 males to green fumiferana females show no dis-550 G. STEHR of the natural populations. Several alleles of varying potency have been found by Glass (1957) in a similar mutant-suppressor system, both components of which were located on autosomes.…”

Section: F2-families (Sib Matings)mentioning

confidence: 99%

Hemolymph Polymorphism in a Moth and the Nature of Sex-Controlled Inheritance

Stehr¹

1959

Evolution

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“…Even more interesting were the cases in which next to the reduced eye an out growth appears in the eye area, covered with bristles, often resembling an antenna. They are similar in appearance to the 'erupt' eyes described by Glass [1957] as a genetic mal formation, just as the missing or greatly re duced eyes resemble the 'eyeless' mutation of Drosophila, or the kidney shaped ones re semble, at least to some extent the wellknown 'Bar' mutation. With other words, they may be considered 'phenocopies', i.e.…”

Section: Resultsmentioning

confidence: 52%

Abnormal Eye Development in Drosophila after Treatment with Vinblastine

Wolsky¹

1983

Pathobiology

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Drosophila cultures, kept on a water-added medium containing 0.16–2.5 µg/ml vinblastine (Velban, Lilly), produced offspring with a high percentage of eye abnormalities. These were eyes completely missing or reduced (moderately or severely) in size, of abnormal shape (‘kidney eyes’) and partially transdetermined into hairy outgrowths resembling antennae. Several of the abnormalities were phenocopies of known mutations, like ‘eyeless’ or ‘erupt’. The abnormally shaped and partially transdetermined eyes had characteristics, namely the appearance of abnormalities in the anterior region of the eye field, which permit conclusions about the probable mechanism of their production during development. These conclusions are in agreement with known facts concerning the mechanism of development of the insect eye and the mode of action of vinblastine.

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In Pursuit of a Gene

Cited by 29 publications

References 10 publications

The Phenogenetics of A Super-Suppressor in Drosophila Melanogaster I. Phenotypic Characterization and Suppressor Efficiency

The Phenogenetics of A Super-Suppressor in Drosophila Melanogaster I. Phenotypic Characterization and Suppressor Efficiency

Hemolymph Polymorphism in a Moth and the Nature of Sex-Controlled Inheritance

Abnormal Eye Development in Drosophila after Treatment with Vinblastine

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