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Gelderman, Monique P.; Vostal, Jaroslav G.

doi:10.1111/j.1537-2995.2012.03898.x

Cited by 1 publication

(2 citation statements)

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“…Results of numerous investigations in this fi eld are evidence of the cytotoxic effects of this nanoparticle [89,17,90,91]. Fullerenol's mechanism of cell death appears to be cell-type-specifi c. Both apoptotic and non-apoptotic mechanisms have been investigated and the results published in the literature [90,92]. Water soluble fullerene derivatives have been reported to cause cell cycle arrest at the G1 phase in Chinese hamster lung and ovary cells [91], as well as suppressed proliferation of human breast cancer cells in a cell line-dependent manner [80].…”

Section: Fullerenol In Vitro Activitymentioning

confidence: 99%

“…These authors concluded that fullerenol did not induce apoptosis based on the failure, but relatively, similarly as in kidney cells [99] induced atophagy. Further study by Gelderman et al [92] on human epithelial HUVEC cells revealed that the fullerenol had both pro-apoptotic and pro-infl ammatory effects on cells, illustrated by fullerenol-induced DNA fragmentation. Additionally, cell cycle capture and increase of intracellular Ca 2+ were observed in cells treated with C 60 (OH) 24 .…”

Section: Fullerenol In Vitro Activitymentioning

confidence: 99%

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Bioimpact of Carbon Nanomaterials

Djordjević

Injac

Mrdjanović

et al. 2013

Advanced Carbon Materials and Technology

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The unique size-dependent properties of carbon nanomaterials (CNMs)-graphene, nanotubes (CNTs) and fullerenes-make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering, and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme-nanotube or antibody-nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C 60 derivatives have been used as: drug and gene delivery vectors, magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C 60 (OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.

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