In response to comments on <scp>IL</scp>‐1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

Diamond, Matthew L.; Boles, Jennifer A.; Ritter, Anne C.; Failla, Michelle D.; Conley, Yvette P.; Kochanek, Patrick M.; Wagner, Amy K.

doi:10.1111/epi.12714

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…A total of 376 patients were described within these studies. Two studies reported no association between CSF cytokine measures and ICP/CPP (55, 57), while one study failed to determine an association between CSF IL-1b and post-traumatic epilepsy (56). Further detail on the “nil association” studies can be found at the bottom of Table 4.…”

Section: Resultsmentioning

confidence: 99%

Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review

et al. 2017

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ObjectiveTo perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients.MethodsTwo separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines. Both were conducted in severe TBI (sTBI) patients only.Data sourcesArticles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched.Study selectionTwo reviewers independently identified all manuscripts utilizing predefined inclusion/exclusion criteria. A two-tier filter of references was conducted.Data extractionPatient demographic and study data were extracted to tables.ResultsThere were 19 studies identified describing the analysis of cytokines via CMD in 267 sTBI patients. Similarly, there were 32 studies identified describing the analysis of CSF cytokines in 1,363 sTBI patients. The two systematic reviews demonstrated: 1. limited literature available on CMD cytokine measurement in sTBI, with some preliminary data supporting feasibility of measurement and associations between cytokines and patient outcome. 2. Various CSF measured cytokines may be associated with patient outcome at 6–12 months, including interleukin (IL)-1b, IL-1ra, IL-6, IL-8, IL-10, and tumor necrosis factor 3. There is little to no literature in support of an association between CSF cytokines and neurophysiologic or tissue outcomes.ConclusionThe evaluation of CMD and CSF cytokines is an emerging area of the literature in sTBI. Further, large prospective multicenter studies on cytokines in CMD and CSF need to be conducted.

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Section: Resultsmentioning

confidence: 99%

Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review

et al. 2017

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“…Consistent with this notion, mice with a CD1 background develop epileptogenesis after controlled cortical impact (CCI)-induced TBI more frequently than mice with a B6 background [5,6]. Studies in humans demonstrate that single nucleotide polymorphisms in genes encoding apolipoprotein E4, glutamic acid decarboxylase 1, A1 adenosine receptor, interleukin-1β, and methylenetetrahydrofolate reductase are associated with the development of posttraumatic epilepsy [7][8][9][10][11]. More candidate genes that increase the likelihood for developing posttraumatic epilepsy remain to be discovered.…”

Section: Introductionmentioning

confidence: 95%

Epileptogenesis after traumatic brain injury in Plau-deficient mice

Bolkvadze

Rantala

Puhakka

et al. 2015

Epilepsy & Behavior

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“…In vivo, TNF- α can activate the intracellular I κ B α and JNK signaling pathways through TLRs, thus contributing to the production of proinflammatory cytokines [ 33 ]. The proinflammatory cytokine, IL-1 β , is a key regulator of acute inflammatory processes in the central nervous system [ 34 , 35 ]. Pathogen-associated molecular patterns of S. aureus can activate inflammatory pathways, and when bound to innate monocytes/macrophages, they result in a significant increase in the secretion of TNF- α and IL-6 [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

IFN-τDisplays Anti-Inflammatory Effects onStaphylococcus aureusEndometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice

Zhang

Guo

Liu

et al. 2017

BioMed Research International

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The aim of the present study was to determine the anti-inflammatory effect of IFN-τ on endometritis using a mouse model of S. aureus-induced endometritis and to elucidate the mechanism of action underlying these effects. In the present study, the effect of IFN-τ on S. aureus growth was monitored by turbidimeter at 600 nm. IFN-τ did not affect S. aureus growth. The histopathological changes indicated that IFN-τ had a protective effect on uterus tissues with S. aureus infection. The ELISA and qPCR results showed the production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 was decreased with IFN-τ treatment. In contrast, the level of the anti-inflammatory cytokine IL-10 was increased. We further studied the signaling pathway associated with these observations, and the qPCR results showed that the expression of TLR2 was repressed by IFN-τ. Furthermore, the western blotting results showed the phosphorylation of IκB, NF-κB p65, and MAPKs (p38, JNK, and ERK) was inhibited by IFN-τ treatment. The results suggested that IFN-τ may be a potential drug for the treatment of uterine infection due to S. aureus or other infectious inflammatory diseases.

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In response to comments on IL‐1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

Cited by 4 publications

References 6 publications

Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review

Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review

Epileptogenesis after traumatic brain injury in Plau-deficient mice

IFN-τDisplays Anti-Inflammatory Effects onStaphylococcus aureusEndometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice

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