In Search of an Oncogene Driver for Squamous Lung Cancer

Abstract

Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

“…In contrast to adenocarcinomas, squamous cancers exhibit relatively fewer actionable mutations. 42 – 44 First, the tyrosine kinase DYRK2 strongly promoted in vitro proliferation and in vivo tumorigenicity of OM organoids, as a highly relevant model for HNSCC. DYRK2, belonging to the cyclin-dependent kinase, mitogen-activated protein kinase, glycogen synthase kinase, and CDC-like kinase (CMGC) superfamily, has been previously implicated in either tumor promotion or inhibition.…”