2019
DOI: 10.1016/j.brainres.2018.10.033
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In search of early neuroradiological biomarkers for Parkinson’s Disease: Alterations in resting state functional connectivity and gray matter microarchitecture in PINK1 −/− rats

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Cited by 24 publications
(29 citation statements)
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“…Resting state BOLD functional connectivity used in this study has been described previously 10 . In brief, preprocessing combined Analysis of Functional NeuroImages (AFNI_17.1.12, http://afni.nimh.nih.gov/afni/), FMRIB Software library (FSL, v5.0.9, http://fsl.fmrib.ox.ac.uk/fsl/), Deformable Registration via Attribute Matching and Mutual-Saliency Weighting (DRAMMS 1.4.1, https://www.cbica.upenn.edu/sbia/software/dramms/index.html) and MATLAB (Mathworks, Natick, MA).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Resting state BOLD functional connectivity used in this study has been described previously 10 . In brief, preprocessing combined Analysis of Functional NeuroImages (AFNI_17.1.12, http://afni.nimh.nih.gov/afni/), FMRIB Software library (FSL, v5.0.9, http://fsl.fmrib.ox.ac.uk/fsl/), Deformable Registration via Attribute Matching and Mutual-Saliency Weighting (DRAMMS 1.4.1, https://www.cbica.upenn.edu/sbia/software/dramms/index.html) and MATLAB (Mathworks, Natick, MA).…”
Section: Methodsmentioning
confidence: 99%
“…A tapered balance beam (Dragonfly Inc., Ridgeley, WV) and rota-rod were used to measure motor behavior 10 . The balance beam (L: 150 cm, W: 5.5 cm tapering down to 1.5 cm, elevated 120 cm) was equally divided into three sections (L:47 cm each; “wide”, “middle”, “thin” sections) that were lined with touch-sensitive sensor ledges (Width: 2 cm) that ran the length of the beam and were arranged on each side, 4 cm below the surface of the beam to count paw slips (or foot faults ).…”
Section: Methodsmentioning
confidence: 99%
“…Similarly, while multiple brain regions develop α-synuclein pathology in PINK1 knockout rat models of PD, the LC appears to be selectively vulnerable to frank neuronal loss ( Grant et al, 2015 ; Cullen et al, 2018 ; Kelm-Nelson et al, 2018 ). fMRI again revealed that loss of TH immunoreactivity was temporally linked to functional connectivity abnormalities in PINK1 knockout rats ( Cai et al, 2019 ). In one of the only studies we found that directly investigated functional connectivity of the LC in rodents, an increase in LC-ventral tegmental area connectivity was reported in PINK1 knockout rats that was associated with anxiety-like behaviors.…”
Section: Animal Studiesmentioning
confidence: 99%
“…Notable increases in brain-wide functional connectivity, including the salience, amygdalar, association, hippocampal, striato-motor, and default mode-like networks, suggest that LC activity can rapidly reconfigure brain state. Importantly, areas modulated by LC activation overlap with dysfunctional networks in rodent models of neurodegeneration ( Grandjean et al, 2014 ; Muñoz-Moreno et al, 2018 ; Anckaerts et al, 2019 ; Cai et al, 2019 ) and human patients ( Hacker et al, 2012 ; Luo et al, 2014 ; Balachandar et al, 2015 ; Badhwar et al, 2017 ). Chemogenetic Gq-DREADD stimulation appears to preferentially increase tonic LC firing rates ( Armbruster et al, 2007 ; Vazey and Aston-Jones, 2014 ), suggesting that elevated tonic LC activity is associated with non-specific increases in brain-wide connectivity.…”
Section: Animal Studiesmentioning
confidence: 99%
“…This was described as a possible functional presynaptic compensatory effect by a yet unknown mechanism. A recent imaging study hypothesized that a reorganization of the anatomical connectivity in the brain occurs to compensate for the loss of DA neurons in the SNpc (Cai et al , 2019; Ferris et al , 2018). In this study, we investigated the reproducibility of the Pink1 −/− rat model by evaluating behavioural dysfunction, loss of DA neurons in the SNpc and extracellular striatal dopamine concentrations in 8-month-old Pink1 −/− male rats.…”
Section: Introductionmentioning
confidence: 99%