2022
DOI: 10.51542/ijscia.v3i1.5
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In Silico Analysis of Potential Nicotine Addiction Treatment by Cinnamomum verum Phytochemicals against nAChRα3 and nAChRα7

Abstract: Nicotine addiction has a direct effect on the occurrence of smoking-related diseases. The receptor that can increase absorption is the neuronal acetylcholine receptor alpha-3 (nAChRα3) and alpha-7 (nAChRα7). This in silico study was conducted to determine the effect of Cinnamomum verum to overcome nicotine addiction by inhibiting the target protein nAChRα3 and nAChRα7. Two hundred and eighty-one phytochemicals Cinnamomum verum were screened into nine ligands by Swiss Adme and PyRx. Molecular visualization and … Show more

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Cited by 4 publications
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“…The tally of hydrogen bonds formed serves as a metric to gauge system stability, with fluctuations indicating alterations in molecular conformation. Additionally, the vigor of the hydrogen bond is appraised through an examination of its potential energy, while its geometry is assessed by scrutinizing the distance and angle between the hydrogen and bonded atoms (Wibowo et al 2022).…”
Section: Strength and Geometry Of Hydrogen Bonds In Molecular Dynamic...mentioning
confidence: 99%
“…The tally of hydrogen bonds formed serves as a metric to gauge system stability, with fluctuations indicating alterations in molecular conformation. Additionally, the vigor of the hydrogen bond is appraised through an examination of its potential energy, while its geometry is assessed by scrutinizing the distance and angle between the hydrogen and bonded atoms (Wibowo et al 2022).…”
Section: Strength and Geometry Of Hydrogen Bonds In Molecular Dynamic...mentioning
confidence: 99%
“…The tally of hydrogen bonds formed serves as a metric to gauge system stability, with fluctuations indicating alterations in molecular conformation. Additionally, the vigor of the hydrogen bond is appraised through an examination of its potential energy, while its geometry is assessed by scrutinizing the distance and angle between the hydrogen and bonded atoms (Wibowo et al 2022).…”
Section: Strength and Geometry Of Hydrogen Bonds In Molecular Dynamic...mentioning
confidence: 99%
“…The tally of hydrogen bonds formed serves as a metric to gauge system stability, with fluctuations indicating alterations in molecular conformation. Additionally, the vigor of the hydrogen bond is appraised through an examination of its potential energy, while its geometry is assessed by scrutinizing the distance and angle between the hydrogen and bonded atoms (Wibowo et al 2022).…”
Section: Strength and Geometry Of Hydrogen Bonds In Molecular Dynamic...mentioning
confidence: 99%