Kesehatan dan kesejahteraan berhak dimiliki oleh setiap orang. Berdasarkan Riskesdas tahun 2013, penduduk yang tergolong kurang aktif tingkat aktivitas fisiknya berada di atas rata-rata. Adanya pandemi COVID-19 mengakibatkan pembatasan kegiatan di luar rumah sehingga mengganggu kegiatan sehari-hari seperti latihan dan aktivitas fisik. Penelitian ini bertujuan untuk mengetahui intensitas aktivitas fisik yang dilakukan oleh pria di masa pandemi COVID-19. Studi cross-sectional dengan metode total sampling dilakukan dalam penelitian ini sehingga didapatkan responden masyarakat berjenis kelamin laki-laki sejumlah 90. Data dikumpulkan dengan mengisi kuesioner GPAQ. Hasil kuisioner menunjukkan bahwa rerata nilai Metabolic Equivalent (MET) untuk total aktivitas fisik adalah 2365.42. Nilai MET tertinggi ada pada domain rekreasi (619.44). Responden yang memiliki intensitas aktivitas fisik yang rendah sebesar 40%, sedang 33% dan tinggi 27%. Aktivitas fisik tinggi banyak dijumpai pada Mahasiswa (25.7%). Rata-rata waktu yang dihabiskan untuk kegiatan menetap adalah 344 menit. Pelajar memiliki waktu kegiatan menetap tertinggi (428.57). Hasil penelitian menunjukkan bahwa sebagian responden masih melakukan aktivitas fisik sedang (33%) dan aktivitas fisik tinggi (27%). Namun persentase lebih besar ada pada aktivitas fisik rendah (40%) yang menandakan bahwa sebagian responden belum memenuhi rekomendasi WHO dalam melakukan aktivitas fisik sehari-hari untuk kesehatan.
Nicotine addiction has a direct effect on the occurrence of smoking-related diseases. The receptor that can increase absorption is the neuronal acetylcholine receptor alpha-3 (nAChRα3) and alpha-7 (nAChRα7). This in silico study was conducted to determine the effect of Cinnamomum verum to overcome nicotine addiction by inhibiting the target protein nAChRα3 and nAChRα7. Two hundred and eighty-one phytochemicals Cinnamomum verum were screened into nine ligands by Swiss Adme and PyRx. Molecular visualization and docking analyzes were performed using Avogadro, AutoDock 4.2., and Biovia Discovery Studio 2016. The docking results showed that 2 of 9 ligands in 4zk4 and 6 of 9 ligands in 3sq9 had hydrogen bonds. Sesquiterpenes is the compound with the highest binding affinity in two proteins. However, in 4zk4, the highest affinity with H-bond is linalool. Phenols is the second ligand that effectively binds amino acids. Phytochemicals in Cinnamomum verum potentially reduce addiction to nicotine by inhibiting the receptor and improving the neuroinflammation due to nicotine. The sesquiterpenes is the primary ligand that binds to the 4zk4 and 3sq9.
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