In Silico Analysis of the Phytochemical Compounds in Carica papaya Seeds for Optimizing the Inhibitors of HMG-CoA Reductase

Inhibition of HMG-CoA Reductase Activity by Kersen Leaves (Muntingia calabura L.) to Prevent Hypercholesterolemia

“…Some in vivo studies have been conducted using ethanol extract of Kersen leaves and found effective to reduce triglycerides and cholesterol levels in hypercholesterolemia rats at doses of 50 to 400 mg/kg of body weight (Putri et al, 2018;Ranti and Vickasari, 2022). The occurrence of alkaloids, flavonoids, phenolics, and steroids might promote the inhibitory effect on HMG-CoA reductase activity based on some in silico studies (Aqeel et al, 2018;Hariyanti et al, 2018;Shaik et al, 2020;Azmi et al, 2021;dan Mannino et al, 2021). Hence, further research on finding HMG-CoA reductase inhibitors from Kersen leaves is a noble challenge.…”

“…Based on research by Hariyanti et al (2018) which used the docking in silico method of a number of secondary metabolites with the HMG-CoA reductase enzyme, it showed that one of the derivatives of steroid compounds in the form of sitosterol has the ability to form hydrogen bonds on the active site of the HMG-CoA reductase. Although the results obtained show a weak interaction, this indicated that steroids have the potential to inhibit the activity of the HMG-CoA reductase enzyme which was related to its ability to form a number of hydrogen bonds at the active site of the enzyme.…”

“…test conducted by Mannino, et al (2021) it was found that the interaction between terpenoids and the active site of HMG-CoA reductase is relatively small. Based on the research of Azmi, et al (2021) and Hariyanti, et al (2018) which used the docking in silico method against a number of alkaloid compounds with HMG-CoA reductase enzyme showed that alkaloid compounds have the ability to form hydrogen bonds on the active site of the HMG-CoA reductase enzyme.…”