2020
DOI: 10.20944/preprints202011.0616.v1
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In Silico Assessment of Class I Antiarrhythmic Drugs Effects on Pitx2-induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues

Abstract: Electrical remodelling as a result of the homeodomain transcription factor 2 (Pitx2)‐dependent gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide polymorphisms at chromosome 4q25 responded favorably to Class I antiarrhythmic drugs (AADs). The possible reasons behind this remain elusive. The purpose of this study was to assess the efficacy of AADs disopyramide, quinidine, and propafenone on human atrial arrhythmias mediated by Pitx2-induced remodelling, from a single c… Show more

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“…The in silico assessments from a recent study unveiled that Pitx-2-induced remodeling increased maximum upstroke velocity and decreased the duration of cardiac action potential, conduction velocity, and wavelength, and that disopyramide appears to be effective against Pitx2-induced atrial fibrillation by prolonging the wavelength [ 8 ].…”
mentioning
confidence: 99%
“…The in silico assessments from a recent study unveiled that Pitx-2-induced remodeling increased maximum upstroke velocity and decreased the duration of cardiac action potential, conduction velocity, and wavelength, and that disopyramide appears to be effective against Pitx2-induced atrial fibrillation by prolonging the wavelength [ 8 ].…”
mentioning
confidence: 99%