In Silico, Combined Plasmonic Photothermal and Photodynamic Therapy in Mice

Kareliotis, Georgios; Chronopoulou, Eleni; Makropoulou, M.

doi:10.3390/jnt3010004

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…96 Animal models can be subjected to therapy, e.g., PTT or PDT, virtually with software such as MATLAB and COSMOL. 97 Such a futuristic approach might also be directed toward in silico assessment of nanoparticle toxicity using algorithms based on the available literature.…”

Section: Toxicity Immunogenicity and Biodegradability Of Plasmonic Na...mentioning

confidence: 99%

“…Use of in silico studies for plasmonic nanoparticles has been reported by Lunnoo et al to predict uptake into mammalian cells . Animal models can be subjected to therapy, e.g., PTT or PDT, virtually with software such as MATLAB and COSMOL . Such a futuristic approach might also be directed toward in silico assessment of nanoparticle toxicity using algorithms based on the available literature.…”

Section: Toxicity Immunogenicity and Biodegradability Of Plasmonic Na...mentioning

confidence: 99%

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Review of Photoresponsive Plasmonic Nanoparticles That Produce Reactive Chemical Species for Photodynamic Therapy of Cancer and Bacterial Infections

Singh

Mazumder

Vincy

et al. 2023

ACS Appl. Nano Mater.

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Increased use of classical drug therapy, including the administration of antibiotics and anticancer drugs, has led to multidrug resistance. Overcoming this resistance requires alternative therapies. Photodynamic therapy is used extensively to combat numerous ailments by killing cells by producing reactive chemical species (RCS). Plasmonic nanomaterials are excellent candidates for bactericidal and neoplastic agents due to their specialized optical properties and capacity to generate RCS. Plasmonic nanomaterials are in great demand for drug delivery, medical diagnostic applications, electronic semiconductors, biomolecular sensing, surface-enhanced Raman spectroscopy, enhancement of materials, and catalysis. This review focuses on plasmonic nanoparticle therapy for bacterial infections and cancers. In particular, mechanisms for RCS formation, toxicity, immunogenicity, and biodegradability of plasmonic nanomaterials are discussed. These materials may become important agents for treating bacterial infections and cancer in the near future, in combination with proper targeting agents and conjugation with biocompatible molecules.

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Section: Toxicity Immunogenicity and Biodegradability Of Plasmonic Na...mentioning

confidence: 99%

Section: Toxicity Immunogenicity and Biodegradability Of Plasmonic Na...mentioning

confidence: 99%

Review of Photoresponsive Plasmonic Nanoparticles That Produce Reactive Chemical Species for Photodynamic Therapy of Cancer and Bacterial Infections

Singh

Mazumder

Vincy

et al. 2023

ACS Appl. Nano Mater.

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Novel Biophotonic Techniques for Phototherapy Enhancement: Cerenkov Radiation as a Bridge between Ionizing and Non-Ionizing Radiation Treatment

Spyratou

Kokkinogoulis

Tsigaridas

et al. 2023

JNT

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In oncology, tremendous research has been conducted on the use of alternative minimally invasive techniques for cancer treatment and diagnosis. The use of biophotonic techniques as a standalone treatment or together with conventional imaging techniques has gained interest among researchers in recent years, while biophotonic therapies such as photothermal and photodynamic therapies tend to bring the use of non-ionizing radiation in therapy back into the spotlight due to the progressive development of optical instrumentation, enhancement agents, molecular probes, light sources and nanocarriers. Thus, the coupling of non-ionizing with ionizing radiation (IR) and the combination of nanomedicine with nuclear medicine procedures are considered to be revolutionary strategies to optimize the therapeutic efficacy of biophotonic modalities and to develop theranostic applications for the better diagnosis and treatment of cancer. Recently, the low-intensity Cerenkov light emitted by tissues as a byproduct of the IR–biostructure interaction has been suggested as an effective internal light source that can trigger phototherapy and guide radiotherapy dosimetry using Cerenkov imaging. This review also provides an overview of in vitro and in vivo studies regarding the use of Cerenkov radiation produced by X-rays or radionucleotides and combined with nanoparticles as a hybrid method to induce enhanced photothermal and photodynamic therapies.

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In Vivo and In Silico Study of Photodynamic Necrosis Volume in Rat Liver

et al. 2022

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Photodynamic therapy is a treatment modality that can be used to treat various types of lesions. To produce cell death, reaching a certain threshold dose of reactive oxygen species (ROS) is required. The estimation of ROS production is of paramount importance to predict the depth of necrosis and to ensure that the volume to be treated receives doses higher than the threshold. In this study, we compared a theoretical model for PDT based on Monte Carlo simulations of light irradiance and rate equations with a rat liver model. At the end of the simulation, necrosis depths and volumes were estimated, as well as the photosensitizer (PS), oxygen, and ROS concentrations at each position of the treated area. From the in vivo study, we obtained the ROS concentration threshold of about 1 mM for Photogem in rat liver. This proposed method can be used for any PS or tissue, including tissues with multiple layers. The proposed method can be used to estimate parameters for any PS or tissue, including layered tissues, as long as their parameters are known. In addition, other protocols can be tested, or compared with the standard ones, providing the bases for analyzing a diverse range of photodynamic treatment scenarios.

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In Silico, Combined Plasmonic Photothermal and Photodynamic Therapy in Mice

Cited by 3 publications

References 63 publications

Review of Photoresponsive Plasmonic Nanoparticles That Produce Reactive Chemical Species for Photodynamic Therapy of Cancer and Bacterial Infections

Review of Photoresponsive Plasmonic Nanoparticles That Produce Reactive Chemical Species for Photodynamic Therapy of Cancer and Bacterial Infections

Novel Biophotonic Techniques for Phototherapy Enhancement: Cerenkov Radiation as a Bridge between Ionizing and Non-Ionizing Radiation Treatment

In Vivo and In Silico Study of Photodynamic Necrosis Volume in Rat Liver

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