2012
DOI: 10.1007/s13596-012-0071-5
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In silico docking studies of phosphodiesterase inhibitory activity of commercially available flavonoids

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Cited by 18 publications
(18 citation statements)
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“…If a compound shows lesser binding energy, it implies that the compounds have higher activity. The extent of forces of attraction or repulsion between the ligand and the receptor depends on the binding or intermolecular energy (Madeswaran et al, 2012). Accordingly, the results of the present study confirmed that the decrease in the binding energy, as well as inhibition constant for the three bioactive compounds (ligands), is responsible for their GSK inhibitory activity.…”
Section: Inhibition Of Glycogen Synthase Kinase 3 Activity By Trigonellinesupporting
confidence: 83%
“…If a compound shows lesser binding energy, it implies that the compounds have higher activity. The extent of forces of attraction or repulsion between the ligand and the receptor depends on the binding or intermolecular energy (Madeswaran et al, 2012). Accordingly, the results of the present study confirmed that the decrease in the binding energy, as well as inhibition constant for the three bioactive compounds (ligands), is responsible for their GSK inhibitory activity.…”
Section: Inhibition Of Glycogen Synthase Kinase 3 Activity By Trigonellinesupporting
confidence: 83%
“…This discovery led to the development of selective COX-2 inhibitors which are a class of compounds with good anti-inflammatory activity and reduced gastrointestinal side effects. The commercially available flavonoids like silbinin, galangin, scopoletin, hesperitin, genistein, daidzein, esculatin, taxifolin, naringenin and celecoxib were also evaluated for COX-inhibitory activity ( 70 ) . The selected flavonoids showed higher binding energy ranging between −8·77 to −6·24 kcal/mol (–36·69 to –26·11 kJ/mol) when compared with that of the standard (−8·30 kcal/mol; –34·73 kJ/mol) which led to the development of potent COX inhibitors for the treatment of inflammation.…”
Section: Current Research and Trends On Flavonoidsmentioning
confidence: 99%
“…Madeswaran et al . ( 70 ) evaluated the COX-inhibitory activity of flavonoids using in silico docking studies. In this perspective, they used flavonoids like farobin-A, gericudranin-B, glaziovianin-A, rutin and xanthotoxin.…”
Section: Current Research and Trends On Flavonoidsmentioning
confidence: 99%
“…Flavonoid dari golongan flavonol, flavon, dan isoflavon memiliki aktivitas anti inflamasi. Hal ini dibuktikan dengan energi ikatan flavonoid pada situs siklooksigenase yaitu -8.77 kcal/mol hingga 6.24 kcal/mol yang tidak berbeda jauh jika dibanding standar Celecoxib (-8.30 kcal/mol) (Madeswaran, 2012). Flavonoid sebagai anti-inflamasi bekerja dengan cara memproduksi pro inflamatori mediator menstimulasi sel yang berkaitan dengan inflamasi seperti limfosit, monosit,natural killer sel, neutrophil, makrofag, dan sel mastosit.…”
Section: Hasil Dan Pembahasanunclassified