In silico evaluation of the antidiabetic activity of natural compounds from Hovenia dulcis Thunberg

Hovenia dulcis Thumberg: Phytochemistry, Pharmacology, Toxicology and Regulatory Framework for Its Use in the European Union

“…The treatment of streptozotocin-induced diabetic rats with 20 or 50 mg/kg −1 of ethyl acetate fraction from an 80% methanolic extract of H. dulcis fruits induced a decrease of plasma glucose, lipid peroxide, total cholesterol and triglycerides in liver microsomes and an increase of glutathione levels in the liver cytosol [ 77 , 78 ]. Furthermore, in a recent in silico analysis performed in order to identify potential pharmacological target of H. dulcis compounds (especially flavonoids) among the main pathways involved in diabetes mellitus, including insulin resistance, glucose level and chronic inflammation, it was suggested that H. dulcis flavonoids may exert their antidiabetic and anti-inflammatory activity through the modulation of AKT1 and glycogen synthase kinase 3 beta (GSK3β) [ 79 ].…”

Green tea infusion prevents diabetic nephropathy aggravation in recent-onset type 1 diabetes regardless of glycemic control

“…A prospective evaluation of compound-protein interactions (CPI) was done with the STITCH v.5.0 database (http://stitch.embl.de/) (Szklarczyk et al, 2016). The CPI settings were done according to (de Godoi et al, 2020). Briefly, the network downloaded from the database was limited to no more than 50 interactions, medium confidence score (0.400), network depth equal to 1, and the following methods of predictions were activated: experiments, databases, co-expression, and predictions.…”

“…densely connected regions) that may suggest functional protein complexes, with the MCODE v.1.6.1 app (Bader and Hogue, 2003). To that, the app was set up as described before (de Godoi et al, 2020). An MCODE score was calculated for each cluster.…”

Natural products targeting inflammation-related metabolic disorders: A comprehensive review

“…Aside from modulating glucose uptake, the consequence of suppression GSK3β is decreased proinflammatory cytokine synthesis leading to an anti-inflammatory effect. [ 55 ] 14 Leea macrophylla Ethanol extract from root Increases insulin secretion, stimulates glucose uptake in the liver, and activates glycogenesis An in vivo study using fructose-fed STZ-induced rats •Three primary compounds in ethanol extract from Leea macrophylla root or Hatikana extract (HKEx), including oleanolic acid, 7α, 28-olean diol, and stigmasterol, have been identified. Treatment of HKEx by using three variety doses in diabetic rats for three weeks significantly lowered blood glucose levels, enhancing liver glycogen and serum insulin.…”