Natural products targeting inflammation-related metabolic disorders: A comprehensive review

Nainu, Firzan; Frediansyah, Andri; Mamada, Sukamto S.; Permana, Andi Dian; Salampe, Mirnawati; Chandran, Deepak; Emran, Talha Bin; Simal-Gándara, Jesús

doi:10.1016/j.heliyon.2023.e16919

Cited by 14 publications

(7 citation statements)

References 319 publications

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“…Alterations in metabolic responses are linked to numerous immunological signaling pathways, for example, metabolic hormones (leptin, resistin, and adiponectin) play various roles in immunological functions. 92 Plants such as Boswellia serrata, Cinnamomum cassia, Citrus bergamia, Coffea arabica, Ficus racemosa, Momordica charantia, Morus Alba, Trigonella foenum graecum , and many others (depicted in Figure 2 ) affect multiple biochemical pathways, displaying not just metabolic but also immunological benefits. Boswellia serrata, Camellia sinensis , and Citrus bergamia are reported to not only improve insulin sensitivity but also reduce the levels of pro-inflammatory cytokines such as IL-6 and TNF-α and positively modulate T lymphocyte proliferation and natural killer (NK) cell function.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review

Febriyanti,

Levita,

Diantini

2024

DDDT

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The relationship between the immune system and metabolic diseases is complex and increasingly recognized as critical to understanding conditions like obesity, diabetes, and cardiovascular diseases. Modulation of the immune system in patients with metabolic disorders can offer several potential benefits. While the salutary impact of plant-derived bioactive compounds on metabolic and immune functions is acknowledged, there is a paucity of comprehensive reviews on the multifaceted and synergistic mechanisms through which these effects are mediated. This review elucidates the therapeutic potential of phytochemical formulations in ameliorating metabolic disorders and delineates their mechanistic implications on relevant biomarkers and immune modulation. Our analysis reveals a predominance of plant species, including Boswellia serrata, Cinnamomum cassia, Citrus bergamia, Coffea arabica, Ficus racemosa, Momordica charantia, Morus Alba , and Trigonella foenum-graecum , that have undergone clinical evaluation and have been substantiated to confer both metabolic and immunological benefits. The phytoconstituents contained in these plants exert their effects through a range of mechanisms, such as improving glucose regulation, reducing inflammatory responses, and modulating immune system. As such, these findings hold considerable promise for clinical and therapeutic translation and necessitate further empirical validation through randomized controlled trials and mechanistic elucidations to affirm the safety and efficacy of herbal formulations.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review

Febriyanti,

Levita,

Diantini

2024

DDDT

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“…One of the primary contributors to the development of GDM is inflammation, which not only leads to insulin resistance but also hampers glucose metabolism ( 137 ). Women diagnosed with GDM often exhibit elevated levels of pro-inflammatory cytokines such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) ( 138 ). These inflammatory mediators disrupt insulin signaling pathways, resulting in insulin resistance and hyperglycemia.…”

Section: Adipokines and Inflammation In Pregnancies With Gestational ...mentioning

confidence: 99%

Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

Ray,

Zeng,

Kusi

et al. 2024

Front. Endocrinol.

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Gestational diabetes mellitus (GDM) poses a significant global health concern, impacting both maternal and fetal well-being. Early detection and treatment are imperative to mitigate adverse outcomes during pregnancy. This review delves into the pivotal role of insulin function and the influence of genetic variants, including SLC30A8, CDKAL1, TCF7L2, IRS1, and GCK, in GDM development. These genetic variations affect beta-cell function and insulin activity in crucial tissues, such as muscle, disrupting glucose regulation during pregnancy. We propose a hypothesis that this variation may disrupt zinc transport, consequently impairing insulin production and secretion, thereby contributing to GDM onset. Furthermore, we discussed the involvement of inflammatory pathways, such as TNF-alpha and IL-6, in predisposing individuals to GDM. Genetic modulation of these pathways may exacerbate glucose metabolism dysregulation observed in GDM patients. We also discussed how GDM affects cardiovascular disease (CVD) through a direct correlation between pregnancy and cardiometabolic function, increasing atherosclerosis, decreased vascular function, dyslipidemia, and hypertension in women with GDM history. However, further research is imperative to unravel the intricate interplay between inflammatory pathways, genetics, and GDM. This understanding is pivotal for devising targeted gene therapies and pharmacological interventions to rectify genetic variations in SLC30A8, CDKAL1, TCF7L2, IRS1, GCK, and other pertinent genes. Ultimately, this review offers insights into the pathophysiological mechanisms of GDM, providing a foundation for developing strategies to mitigate its impact.

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“…Additionally, polyphenols and omega-3 fatty acids show substantial efficacy in regulating oxidative stress, inflammation, and insulin resistance. This holistic strategy, utilizing diverse bioactive compounds, offers an integrated approach to combat oxidative and inflammatory challenges in metabolic disorders, potentially enhancing the effectiveness of conventional treatments [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting Metabolic Diseases: The Role of Nutraceuticals in Modulating Oxidative Stress and Inflammation

Dama,

Shpati,

Daliu

et al. 2024

Nutrients

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The escalating prevalence of metabolic and cardiometabolic disorders, often characterized by oxidative stress and chronic inflammation, poses significant health challenges globally. As the traditional therapeutic approaches may sometimes fall short in managing these health conditions, attention is growing toward nutraceuticals worldwide; with compounds being obtained from natural sources with potential therapeutic beneficial effects being shown to potentially support and, in some cases, replace pharmacological treatments, especially for individuals who do not qualify for conventional pharmacological treatments. This review delves into the burgeoning field of nutraceutical-based pharmacological modulation as a promising strategy for attenuating oxidative stress and inflammation in metabolic and cardiometabolic disorders. Drawing from an extensive body of research, the review showcases various nutraceutical agents, such as polyphenols, omega-3 fatty acids, and antioxidants, which exhibit antioxidative and anti-inflammatory properties. All these can be classified as novel nutraceutical-based drugs that are capable of regulating pathways to mitigate oxidative-stress- and inflammation-associated metabolic diseases. By exploring the mechanisms through which nutraceuticals interact with oxidative stress pathways and immune responses, this review highlights their potential to restore redox balance and temper chronic inflammation. Additionally, the challenges and prospects of nutraceutical-based interventions are discussed, encompassing bioavailability enhancement, personalized treatment approaches, and clinical translation. Through a comprehensive analysis of the latest scientific reports, this article underscores the potential of nutraceutical-based pharmacological treatment modulation as a novel avenue to fight oxidative stress and inflammation in the complex landscape of metabolic disorders, particularly accentuating their impact on cardiovascular health.

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Natural products targeting inflammation-related metabolic disorders: A comprehensive review

Cited by 14 publications

References 319 publications

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review

Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

Targeting Metabolic Diseases: The Role of Nutraceuticals in Modulating Oxidative Stress and Inflammation

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