In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders

Assis, Pollyana Mendonça de; Fávero, Amanda; Menegasso, Jaíne Ferrareis; Meinel, Raíssa Soares; Marion, G.M.; Nunes, Vinicius Schmitz; Goliatt, Priscila Vanessa Zabala Capriles; Silva, Adilson David da; Dutra, Rafael Cypriano; Raposo, Nádia Rezende Barbosa

doi:10.1016/j.lfs.2020.117538

Cited by 9 publications

(7 citation statements)

References 79 publications

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“…Next, we induced the depressant‐like behavior by a single LPS systemic challenge (de Assis et al, 2020; Zhao et al, 2019). The acute preventive treatment with RA (50 mg/kg; p.o.)…”

Section: Resultsmentioning

confidence: 99%

“…To identify the ligands of RA that could suggest its potential pharmacological effects and mechanisms of action, we used Swiss Target Prediction (http://www.swisstargetprediction.ch/) (de Assis et al, 2020) and PASS online (http://www.pharmaexpert.ru/passonline/) (Gonçalves et al, 2020; Poroikov et al, 2019). They are free online servers that can predict small molecules' targets in humans and other vertebrates.…”

Section: Methodsmentioning

confidence: 99%

“…These parameters comprise the pharmacokinetic profile of compounds and are essential to determine their pharmacodynamics activities (Nisha et al, 2016). In this study, we used two online free tools: (a) Swiss ADME (http://www.swissadme.ch/index.php) (Daina, Michielin, & Zoete, 2017; de Assis et al, 2020), and (b) ADMET SAR servers (http://lmmd.ecust.edu.cn/admetsar2/) (Cheng et al, 2012; Gonçalves et al, 2020) using SMILES of RA.…”

Section: Methodsmentioning

confidence: 99%

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Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Lataliza

Assis

Laurindo

et al. 2021

Phytotherapy Research

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Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, has anti-inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug-likeness and the potential molecular targets to RA. Moreover, it tested the antidepressant-like potential of RA in the lipopolysaccharide (LPS)-induced depression model. RA (MW = 360.31 g/mol) meets the criteria of both Lipinski's rule of five and the Ghose filter. It also attends to relevant pharmacokinetic parameters.Target prediction analysis identified RA's potential targets and biological activities, including the peroxisome proliferator-activated receptor (PPAR) and the cannabinoid receptors CB 1 and CB 2 . In vivo, RA's acute, repetitive, and therapeutic administration showed antidepressant-like effect since it significantly reduced the immobility time in the tail suspension test and increased grooming time in the splash test. Further, the pretreatment with antagonists of CB 1 , CB 2 , and PPAR-γ receptors significantly blocked the antidepressant-like effect of RA. Altogether, our findings suggest that cannabinoid receptors/PPAR-γ signaling pathways are involved with the antidepressant-like effect of RA. Moreover, this molecule meets important physicochemical and pharmacokinetic parameters that favor its bioavailability. RA constitutes a promising, innovative, and safe molecule for the pharmacotherapy of major depressive disorder.

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“…Next, we induced the depressant‐like behavior by a single LPS systemic challenge (de Assis et al, 2020; Zhao et al, 2019). The acute preventive treatment with RA (50 mg/kg; p.o.)…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Lataliza

Assis

Laurindo

et al. 2021

Phytotherapy Research

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“…Resveratrol has also been shown to mitigate neuronal cell death, inflammation, and oxidative stress [ 88 ]. In addition to being indicated as a potential alternative for neuroinflammatory diseases, based on in vitro and in vivo studies, it is also revealed as an important compound with neuroprotective action [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review

Fernandes

Costa

Freire

et al. 2021

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Background: Neural cells undergo functional or sensory loss due to neurological disorders. In addition to environmental or genetic factors, oxidative stress is a major contributor to neurodegeneration. In this context, there has been a growing interest in investigating the effects of essential oils (EOs) in recent years, especially in the treatment of neuropathologies. The chemical and biological effects of EOs have led to important treatment tools for the management of various neurological disorders. Objective: In the present study we performed a systematic review that sought to comprehend the neuroprotective effects of different EOs. Method: This work is a systematic review where an electronic search was performed on PubMed, Science direct, Cochrane Library and SciELO (Scientific Electronic Library Online) databases, covering the last 10 years, using “Essential oil” and “Neuroprotective effect” as reference terms. Results: A total of 9 articles were identified, in which the efficacy of EOs was described in experimental models of anxiety, dementia, oxidative stress, cerebral ischemia, Alzheimer’s disease and oxidative toxicity. Conclusion: EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.

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“…de Assis et al (2020) investigated a series of resveratrol analogs, identifying RSVA6 as the most promising candidate for its potential antidepressant‐like properties. RSVA6 functions as an acetylcholinesterase (AChE) inhibitor, exhibiting greater activity than resveratrol.…”

Section: Stilbenes In Neuropsychiatric and Neurological Disordersmentioning

confidence: 99%

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Socała,

Żmudzka,

Lustyk

et al. 2024

Phytotherapy Research

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Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi‐target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders. We describe and discuss the results of both in vitro and in vivo studies. The majority of studies concentrate on resveratrol, with limited findings exploring other stilbenes such as pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic resveratrol derivatives. Overall, although extensive preclinical studies show the potential benefits of stilbenes in various central nervous system disorders, clinical evidence on their therapeutic efficacy is largely missing.

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In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders

Cited by 9 publications

References 79 publications

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

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