“…ERFE, also known as CTRP15, is a member of the C1q tumor necrosis factor-related protein family. In a pan-cancer study, Xu et al [42] found that ERFE overexpression indicated poor prognosis of breast cancer, colon cancer, pancreatic cancer, and renal clear cell carcinoma, consistent with the results of this study. This aspect requires further functional analysis and may have potential clinical value, as ERFE could be developed as a therapeutic target for CRC.…”