In Situ Analysis of the Immune Microenvironment of the Adenoid in Children with and without Secretory Otitis Media

Forsgren, Joachim; Rynnel-Dagöö, Britta; Christensson, Birger

doi:10.1177/000348949510400303

Cited by 18 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LC in the adenoid were first demonstrated by van Nieuwkerk [16]. Forsgren described a large interindividual variation in CD1a + cell numbers in the interfollicular spaces [17]. Patients in these studies were not screened for allergy, which means that the patients with high interfollicular CD1a + cell counts could well be allergic patients.…”

Section: Discussionmentioning

confidence: 99%

Differences in cellular infiltrates in the adenoid of allergic children compared with age‐ and gender‐matched controls

Fokkens

Vinke

Jong

et al. 1998

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Differences in cellular infiltrates in the adenoid of allergic children compared with age‐ and gender‐matched controls

Fokkens

Vinke

Jong

et al. 1998

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…The interfollicular area of the adenoids is composed mainly of T lymphocytes and most of them are CD4 þ T helper lymphocytes. CD8 þ suppressor/cytotoxic T lymphocytes are less frequent in the adenoids and their proportion to CD4 þ T lymphocytes is highest in the subepithelial tissue and lowest in the follicles [15,16]. B lymphocytes are found mainly in the follicles.…”

Section: Discussionmentioning

confidence: 99%

Age‐Associated Changes in the Cellular Composition of the Human Adenoid

Mattila

Tarkkanen

1997

Scand J Immunol

View full text Add to dashboard Cite

Mattila PS, Tarkkanen J. Age-Associated Changes in the Cellular Composition of the Human Adenoid. Scand J Immunol 1997;45:423-427 Histological investigations suggest that the size and number of lymphoid follicles of the adenoids and tonsils decrease during ageing. The mechanisms underlying the histological changes are unknown. The authors have analysed the frequency of lymphocyte subpopulations in the adenoids by flow cytometry. The proportion of B lymphocytes decreased and the proportion of T lymphocytes of all mononuclear cells increased with age. Of all B lymphocytes the proportion of CD38 þ , surface IgD ¹ B lymphocytes representing the germinal centre cell phenotype, decreased and the proportion of CD38 ¹ , IgD ¹ B lymphocytes representing the mature B lymphocyte phenotype, increased with age. The expression of CD23, a cell surface molecule associated with activation of follicular mantle IgD þ B lymphocytes, did not change with increasing age. The results imply that the involution of the adenoid is associated with a decreased germinal centre reaction and relative accumulation of mature B cells in the adenoidal tissue, as analysed by three-colour flow cytometry.

show abstract

“…A few studies have focused on the proportion of the immunoglobulin isotype expression of B cells [8], CD4 + T cells and CD8 + T cells [9,10] in enlarged adenoids from patients with and without discharge from the middle ear. Though the clinical difference was obvious when comparing the two patient groups, no clear-cut difference could be demonstrated with regard to the B cell or T cell lineage.…”

Section: Introductionmentioning

confidence: 99%

Abundance of intraepithelial γδ T cells in hypertrophic obstructive but not in chronically infected adenoids

Olofsson

Hellström

Hammarström

1996

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYUsing quantitative morphometric analysis of immunohistochemically stained tissue sections we compared hypertrophic obstructive adenoids (HOA, n = 10) from children without middle ear disease with chronically infected adenoids (CIA, n = 10) from children with middle ear disease.°± T cell receptor (TCR) cells constituted the dominating T cell population in the surface epithelium of HOA, while ® ¯T CR cells were the dominating intraepithelial T cell population in CIA. Intraepithelially CD8 cells dominated over CD4 cells in both diseases. Intraepithelially B cells were not detected. The cellular composition of follicles, with B cells dominating followed by activated CD4 ® ¯ T CR cells, was the same in both groups. However, the number of follicles in CIA was twice as many as in HOA. In the deeper interfollicular areas granulocytes were more abundant in CIA than in HOA. The latter two findings suggest a more pronounced inflammatory response in the adenoids of patients with middle ear disease. There was no significant difference with regard to pathogenic bacterial strains colonizing the adenoid surface when comparing the two patient groups. These results suggest that in patients with HOA°± TCR T cells help to maintain the integrity of the surface epithelium, thereby preserving its protective function. On the basis of our results we speculate that CIA have a malfunctioning defence, thereby facilitating long-standing infections deep in the adenoid. This may be the main reason for development of middle ear disease and an indication for adenoidectomy in patients with CIA.

show abstract

In Situ Analysis of the Immune Microenvironment of the Adenoid in Children with and without Secretory Otitis Media

Cited by 18 publications

References 21 publications

Differences in cellular infiltrates in the adenoid of allergic children compared with age‐ and gender‐matched controls

Differences in cellular infiltrates in the adenoid of allergic children compared with age‐ and gender‐matched controls

Age‐Associated Changes in the Cellular Composition of the Human Adenoid

Abundance of intraepithelial γδ T cells in hypertrophic obstructive but not in chronically infected adenoids

Contact Info

Product

Resources

About