In Situ Biomineralized Phosphorylated Poly(<scp>l</scp>-Glutamic Acid)/Sodium Alginate Injectable Hydrogels

Jin-hong, GU; Feng, Long; Yan, Shifeng; Yin, Jingbo

doi:10.1080/00222348.2021.1995947

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Aminolysis of the PLGA-NHS in the presence of ADH led to the formation of PLGA-ADH (Figure S1a). 49 The synthesis of PLGA-ADH was verified by the 1 H NMR spectrum with a new peak at 1.65 ppm, which was ascribed to the methylene protons (4H, CH 2 CH 2 ) of ADH. The calculated PLGA-ADH modification rate was about 54% (Figure S1c).…”

Section: Hydrogel Formation and Gelation Timementioning

confidence: 94%

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Niu

Shi

et al. 2023

ACS Biomater. Sci. Eng.

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Injectable hydrogels have drawn much attention in the field of tissue engineering because of advantages such as simple operation, strong plasticity, and good biocompatibility and biodegradability. Herein, we propose the novel design of injectable hydrogels via a Schiff base cross-linking reaction between adipic dihydrazide (ADH)-modified poly(l-glutamic acid) (PLGA-ADH) and benzaldehyde-terminated poly(ethylene glycol) (PEG-CHO). The effects of the mass fraction and the molar ratio of −CHO/–NH2 on the gelation time, mechanical properties, equilibrium swelling, and in vitro degradation of the hydrogels were examined. The PLGA/PEG hydrogels cross-linked by dynamic Schiff base linkages exhibited good self-healing ability. Additionally, the PLGA/PEG hydrogels had good biocompatibility with bone marrow-derived mesenchymal stem cells (BMSCs) and could effectively support BMSC proliferation and deposition of glycosaminoglycans and upregulate the expression of cartilage-specific genes. In a rat cartilage defect model, PLGA/PEG hydrogels significantly promoted new cartilage formation. The results suggest the prospect of the PLGA/PEG hydrogels in cartilage tissue engineering.

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Section: Hydrogel Formation and Gelation Timementioning

confidence: 94%

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Niu

Shi

et al. 2023

ACS Biomater. Sci. Eng.

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“…Therefore, it can be degraded in the microenvironment of bacterial infection with a high concentration of V8 and release of Ag NPs and ions, resulting in the on-demand release of drugs along with a good antimicrobial performance at the implantation site. Moreover, the PG as a synthetic EZRH is biocompatible and has the potential to promote cell and tissue growth ( Figure 9 B) [ 100 ]. The cumulative release profile in Figure 9 C proved that the release of Ag ions was very fast during the first 6 h of incubation in the presence of the V8 enzyme.…”

Section: Biomolecule-responsive Hydrogelsmentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

167

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

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Cartilage and bone injectable hydrogels: A review of injectability methods and treatment strategies for repair in tissue engineering

Shaygani,

Mofrad,

Demneh

et al. 2024

International Journal of Biological Macromolecules

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In Situ Biomineralized Phosphorylated Poly(l-Glutamic Acid)/Sodium Alginate Injectable Hydrogels

Cited by 3 publications

References 30 publications

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Smart Hydrogels for Advanced Drug Delivery Systems

Cartilage and bone injectable hydrogels: A review of injectability methods and treatment strategies for repair in tissue engineering

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