In situ colonisation and immunomodulation by the probiotic lactobacillus reuteri (ATCC 55730) in the human gastrointestinal tract

Connolly, Eamonn; Valeur, Nana; Engel, Peter J.; Carbajal, Noris; Ladefoged, Karin

doi:10.1016/s0261-5614(03)80211-x

Cited by 5 publications

(3 citation statements)

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“…The selection process is shown in Figure 2. Table 1 gives a list of 38 studies which were excluded for: use of breast milk or mixed feeds (12 studies), no use of probiotic or prebiotic (2 studies), being a cross over study, not RCT (5 studies), type of feed was unspecified (3 studies), different inclusion criteria or outcomes (12 studies), no data available for end of treatment period (1 study) and data presentation inappropriate for meta- analysis (3 studies) [57-94]. No eligible studies were excluded for failure to report the review’s pre-specified outcomes.…”

Section: Resultsmentioning

confidence: 99%

Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review

Mugambi

Musekiwa

Lombard

et al. 2012

Nutr J

132

110

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BackgroundSynbiotics, probiotics or prebiotics are being added to infant formula to promote growth and development in infants. Previous reviews (2007 to 2011) on term infants given probiotics or prebiotics focused on prevention of allergic disease and food hypersensitivity. This review focused on growth and clinical outcomes in term infants fed only infant formula containing synbiotics, probiotics or prebiotics.MethodsCochrane methodology was followed using randomized controlled trials (RCTs) which compared term infant formula containing probiotics, prebiotics or synbiotics to conventional infant formula with / without placebo among healthy full term infants. The mean difference (MD) and corresponding 95% confidence intervals (CI) were reported for continuous outcomes, risk ratio (RR) and corresponding 95% CI for dichotomous outcomes. Where appropriate, meta-analysis was performed; heterogeneity was explored using subgroup and sensitivity analyses. If studies were too diverse a narrative synthesis was provided.ResultsThree synbiotic studies (N = 475), 10 probiotics studies (N = 933) and 12 prebiotics studies (N = 1563) were included. Synbiotics failed to significantly increase growth in boys and girls. Use of synbiotics increased stool frequency, had no impact on stool consistency, colic, spitting up / regurgitation, crying, restlessness or vomiting. Probiotics in formula also failed to have any significant effect on growth, stool frequency or consistency. Probiotics did not lower the incidence of diarrhoea, colic, spitting up / regurgitation, crying, restlessness or vomiting. Prebiotics in formula did increase weight gain but had no impact on length or head circumference gain. Prebiotics increased stool frequency but had no impact on stool consistency, the incidence of colic, spitting up / regurgitation, crying, restlessness or vomiting. There was no impact of prebiotics on the volume of formula tolerated, infections and gastrointestinal microflora. The quality of evidence was compromised by imprecision, inconsistency of results, use of different study preparations and publication bias.Authors’ conclusionsThere is not enough evidence to state that supplementation of term infant formula with synbiotics, probiotics or prebiotics does result in improved growth or clinical outcomes in term infants. There is no data available to establish if synbiotics are superior to probiotics or prebiotics.

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Section: Resultsmentioning

confidence: 99%

Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review

Mugambi

Musekiwa

Lombard

et al. 2012

Nutr J

132

110

View full text Add to dashboard Cite

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“…2003). Additionally, there is a growing body of evidence that probiotics can stimulate host immunity, occupy potential pathogen colonization sites and interrupt host–pathogen ‘cross‐talking’ (Connolly et al. 2003; Freitas et al.…”

Section: Introductionmentioning

confidence: 99%

“…Probiotics have had some success when applied to the intestinal tract and vagina after antibiotic therapy and for the management of infections in which it is perceived that there is an 'imbalance' of the normal microbiota allowing unregulated growth of 'problematic' micro-organisms (Cadieux et al 2002;Reid et al 2003). Additionally, there is a growing body of evidence that probiotics can stimulate host immunity, occupy potential pathogen colonization sites and interrupt host-pathogen 'cross-talking' (Connolly et al 2003;Freitas et al 2003;Gill 2003;Valeur et al 2004).…”

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confidence: 99%

A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters

et al. 2006

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Aims: To determine whether dosing with bacteriocin‐producing Streptococcus salivarius following an antimicrobial mouthwash effects a change in oral malodour parameters and in the composition of the oral microbiota of subjects with halitosis. Materials and Results: Twenty‐three subjects with halitosis undertook a 3‐day regimen of chlorhexidine (CHX) mouth rinsing, followed at intervals by the use of lozenges containing either S. salivarius K12 or placebo. Assessment of the subjects’ volatile sulphur compound (VSC) levels 1 week after treatment initiation showed that 85% of the K12‐treated group and 30% of the placebo group had substantial (>100 ppb) reductions. The bacterial composition of the saliva was monitored by culture and PCR‐denaturing gradient gel electrophoresis (PCR‐DGGE). Changes in the PCR‐DGGE profiles occurred in most subjects following K12 treatment. In vitro testing showed that S. salivarius K12 suppressed the growth of black‐pigmented bacteria in saliva samples and also in various reference strains of bacteria implicated in halitosis. Conclusions: Administration of bacteriocin‐producing S. salivarius after an oral antimicrobial mouthwash reduces oral VSC levels. Significance and Impact of the Study: The outcome of this preliminary study indicates that the replacement of bacteria implicated in halitosis by colonization with competitive bacteria such as S. salivarius K12 may provide an effective strategy to reduce the severity of halitosis.

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Enhancement in Ex Vivo Phagocytic Capacity of Peritoneal Leukocytes in Mice by Oral Delivery of Various Lactic-Acid-Producing Bacteria

Lee

2004

Curr Microbiol

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Lactic-acid-producing bacteria (LABs) are known to have immunomodulating activity. In the current study, various LABs were tested for their immunity-enhancing activity, especially the phagocytic activity of leukocytes. Viable but not heat-killed cells of Weissella kimchii strain PL9001, Lactobacillus fermentum strain PL9005, and L. plantarum strain PL9011 significantly increased the ex vivo phagocytic capacity of mouse peritoneal leukocytes to ingest fluorescein isothiocyanate (FITC)-labeled Escherichia coli in a strain-dependent manner. Results of this and previous studies suggest these LABs as candidates for new probiotics. This is the first report of the enhancement of peritoneal leukocyte activity of these species.

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In situ colonisation and immunomodulation by the probiotic lactobacillus reuteri (ATCC 55730) in the human gastrointestinal tract

Cited by 5 publications

References 0 publications

Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review

Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review

A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters

Enhancement in Ex Vivo Phagocytic Capacity of Peritoneal Leukocytes in Mice by Oral Delivery of Various Lactic-Acid-Producing Bacteria

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