In situ derivatization hollow fiber mediated liquid phase microextraction of alkylphosphonic acids from water

Pardasani, Deepak; Kanaujia, Pankaj K.; Gupta, Atul; Tak, Vijay; Shrivastava, R. K.; Dubey, D. K.

doi:10.1016/j.chroma.2006.12.010

Cited by 45 publications

(18 citation statements)

References 15 publications

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“…To extract AMPAs from aqueous samples, most sample treatment methods described in publications consist of extractionderivation procedures to perform GC-MS analysis of the derivatized AMPAs (solid phase extraction [25], solid phase microextraction [2], microemulsion [26], hollow-fiber liquid phase microextraction [27,28]). This study focuses on sample treatment prior to LC-MS analysis.…”

Section: Introductionmentioning

confidence: 99%

Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples

Desoubries

Chapuis-Hugon

Bossée³

et al. 2012

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples

Desoubries

Chapuis-Hugon

Bossée³

et al. 2012

Journal of Chromatography B

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“…To compare the detection limits of MPA alkyl esters by gas chromatog raphy-mass spectrometry (GC-MS) after the extrac tion from water using hollow fiber LPME, preconcen tration, and derivatization with alkyl bromide were 0.1-0.75 µg/cm 3 [38], and in the form of derivatives with N (tert butyldimethylsilyl) N methyltrifluoro acetamide by GC-MS, 0.01⎯0.54 µg/dm 3 (the total ion current mode) [39]. The ion pair solid phase extraction of the esters of APAs (methyl, ethyl, propyl, butyl) from water, followed by their methylation and determination by GC-MS, yielded the detection limits of 0.1-0.2 µg/cm 3 and 10-15 ng/cm 3 in the total ion current mode and in the selected ion mode, respectively [40].…”

Section: Methods Of Ionization and Detection Of Degradation Productsmentioning

confidence: 99%

Liquid chromatography with mass-spectrometric detection for the determination of chemical warfare agents and their degradation products

Aleksenko

2012

J Anal Chem

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In connection with the ratification of the Conven tion and the beginning of the destruction of chemical weapons, the determination of chemical warfare agents (CWA) and their degradation products (DP) has become particularly important in the late 1990s. First of all, this is due to that the safety of the person nel and the public need to be ensured during storage, transportation, and destruction of chemical weapons. The latter suggests the implementation of the system for continuous monitoring of the destruction of CWA and the concentration of CWA and products of their degradation in the environment. The derivatives of alkylphosphonic acids (APAs) are among the main DP of organophosphorus nerve agents, while thiodiglycol and sulfur and oxygen containing long chain diols are for blister agents (Fig. 1). In the last decade, a growing number of publications have been devoted to the identification of these compounds by gas chroma tography (GC), HPLC, and capillary electrophoresis. Gas chromatography coupled with mass spectromet ric detection remains one of the most reliable methods for determining agents in most cases due to its high sensitivity and selectivity and the presence of large libraries of mass spectra [1]. However, the determina tion of DP in water samples, water extracts from soil, or biological fluids requires the transfer of compounds from the aqueous phase into the organic phase, fol lowed by derivatization. In those cases, the application of HPLC is more perspective. A conventional spectro photometric detector is of little use in determining CWA and DP because of the lack of chromophoric groups in their molecules. The development of inter faces that allow the combination of HPLC with mass spectrometry (HPLC-MS) greatly expanded the pos sibilities of the method for the identification and quantification of these substances.Achievements, constraints, and prospects of the development of HPLC-MS for the determination of CWA and DP were previously analyzed in several reviews [2][3][4][5]. Applied aspects of the method for determining various hazardous agents, including chemical warfare agents, for the period of 2002-2005 are presented in [2]. A place of HPLC among other chromatographic and electrophoretic methods for the determination of CWA and DP is considered [3][4][5]. We should also note the book, a chapter of which is devoted to the use of HPLC-MS for the determina tion of substances prohibited by the Convention [6]. However, similar works have not been published over the past 5 years. This review summarizes the results of the application of HPLC-MS for the determination of CWA and DP for 13 years have passed since the rat Abstract-This review summarizes the results of high performance liquid chromatography with mass spec trometric detection (HPLC-MS) in the identification of chemical warfare agents and their degradation products, obtained in the last 13 years passed since the ratification of the Convention on the Prohibition of the Development, Production, Stockpiling, and Use of Chemical Weapons and ...

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“…The hollow fiber also provides additional filtration to prevent particles from entering the lumen of the fiber. Hollow fiber-based LPME has been shown to be a simple, fast, and inexpensive sample preparation procedure, and has been used to analyze environmental pollutants, biochemical warfare agents, and pharmaceutical residues [9,[18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Determination of Trace Chloroanilines in Environmental Water Samples Using Hollow Fiber-Based Liquid Phase Microextraction

et al. 2011

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A liquid phase microextraction method using hollow fiber to support extraction solvent was developed for enrichment of trace level chloroanilines in environmental water samples. Target analytes, 2-chloroaniline, 3-chloroaniline, 2,3-dichloroaniline, 2,4-dichloroaniline, 3,4-dichloroaniline, and 3,5-dichloroaniline were determined using gas chromatography-flame ionization detector after extraction. Experimental conditions that affect extraction efficiency were investigated and optimized. The proposed method showed a wide linear range from lower lg L -1 to 1,000 lg L -1 , low detection limits (B5.1 lg L -1 ), and reasonable relative standard deviations (RSDs \ 13%). Feasibility of the method was evaluated by analyzing river water samples collected from the Hudson River and the East River in New York City.

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In situ derivatization hollow fiber mediated liquid phase microextraction of alkylphosphonic acids from water

Cited by 45 publications

References 15 publications

Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples

Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples

Liquid chromatography with mass-spectrometric detection for the determination of chemical warfare agents and their degradation products

Determination of Trace Chloroanilines in Environmental Water Samples Using Hollow Fiber-Based Liquid Phase Microextraction

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