In-situ detoxification strategies to boost bioalcohol production from lignocellulosic biomass

Nogueira, Cleitiane da Costa; Padilha, Carlos Eduardo de Araújo; Dantas, Júlia Maria de Medeiros; Medeiros, Fábio Gonçalves Macêdo de; Guilherme, A. De A.; Souza, Domingos Fabiano de Santana; Santos, Everaldo Silvino dos

doi:10.1016/j.renene.2021.09.012

Cited by 28 publications

(8 citation statements)

References 254 publications

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“…The authors reported mannitol and citric acid production using glycerol as the sole C source. Besides furan compounds, Y. lipolytica also metabolized acetic acid, which was consumed in the first 48 h. This is of great importance as short chain organic acids are among the most abundant degradation by-products with inhibitory effects in biomass hydrolyzates [60]. For example, Poontawee et al [55], found a significant decrease in biomass and lipid concentration by 72% and 97%, respectively, for R. fluviale DMKU-SP314, when acetic acid concentration was higher than 1.0 g L −1 .…”

Section: Yeast Performance In Hydrolyzate Under Different Concentrati...mentioning

confidence: 99%

Optimized conversion of wheat straw into single cell oils by Yarrowia lipolytica and Lipomyces tetrasporus and synthesis of advanced biofuels

et al. 2023

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Section: Yeast Performance In Hydrolyzate Under Different Concentrati...mentioning

confidence: 99%

Optimized conversion of wheat straw into single cell oils by Yarrowia lipolytica and Lipomyces tetrasporus and synthesis of advanced biofuels

et al. 2023

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“…The most common methods to discard inhibitors from biomass and ensure higher bioethanol yield and productivity are, nowadays, various in situ strategies, including membrane extraction, solvent extraction, ion exchange, membrane bioreactors, adsorption, microbial adaptation, using microbial consortium or engineered microorganisms, and several other techniques that are tailored according to pretreatment, hydrolysis, and fermentation methods used in the ethanol production process. Detoxification may be performed separately or integrated into hydrolysis or fermentation [12,102,103].…”

Section: Detoxificationmentioning

confidence: 99%

Bioethanol Production from Lignocellulosic Biomass—Challenges and Solutions

2022

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Regarding the limited resources for fossil fuels and increasing global energy demands, greenhouse gas emissions, and climate change, there is a need to find alternative energy sources that are sustainable, environmentally friendly, renewable, and economically viable. In the last several decades, interest in second-generation bioethanol production from non-food lignocellulosic biomass in the form of organic residues rapidly increased because of its abundance, renewability, and low cost. Bioethanol production fits into the strategy of a circular economy and zero waste plans, and using ethanol as an alternative fuel gives the world economy a chance to become independent of the petrochemical industry, providing energy security and environmental safety. However, the conversion of biomass into ethanol is a challenging and multi-stage process because of the variation in the biochemical composition of biomass and the recalcitrance of lignin, the aromatic component of lignocellulose. Therefore, the commercial production of cellulosic ethanol has not yet become well-received commercially, being hampered by high research and production costs, and substantial effort is needed to make it more widespread and profitable. This review summarises the state of the art in bioethanol production from lignocellulosic biomass, highlights the most challenging steps of the process, including pretreatment stages required to fragment biomass components and further enzymatic hydrolysis and fermentation, presents the most recent technological advances to overcome the challenges and high costs, and discusses future perspectives of second-generation biorefineries.

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“…Although various technologies, such as physical adsorption, chemical treatment, and biological degradation, have been developed for detoxifying the hydrolysate of lignocellulosic biomass, none of them is economically feasible for industrial applications (Nogueira et al, 2021). Meanwhile, tolerance to individual stresses such as ethanol, acetic acid, and high temperature has been studied for Z. mobilis (Carreón-Rodríguez et al, 2019;Yang et al, 2020;Li et al, 2021), but the progress is less significant because multiple stresses always co-exist under industrial production conditions, and general stress responses are preferred (Guan et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Intracellular accumulation of c-di-GMP and its regulation on self-flocculation of the bacterial cells from Zymomonas mobilis

Bai

Xia

et al. 2023

Preprint

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Zymomonas mobilis is an emerging chassis for being engineered to produce bulk products due to its glycolysis through the Entner-Doudoroff pathway with less ATP produced for lower biomass accumulation and higher yields with targeted products. When self-flocculated, the bacterial cells are more productive and tolerant to stresses for high product titers, but this morphology needs to be controlled properly to avoid internal mass transfer limitation associated with strong flocculation. Herewith we explored the regulation of cyclic diguanosine monophosphate (c-di-GMP) on self-flocculation of the bacterial cells through cellulose biosynthesis. While ZMO1365 and ZMO0919 with GGDEF domains for diguanylate cyclase activities catalyze c-di-GMP biosynthesis, ZMO1487 with an EAL domain for phosphodiesterase activities catalyzes c-di-GMP degradation, but ZMO1055 and ZMO0401 contain the dual domains with phosphodiesterase activities predominated. Since c-di-GMP is synthesized from GTP, the intracellular accumulation of this signal molecule through deactivating the activity of phosphodiesterase is preferred for activating cellulose biosynthesis to flocculate the bacterial cells, since such a strategy exerts less perturbance on intracellular processes regulated by GTP. These discoveries are significant not only for engineering unicellular Z. mobilis strains with the self-flocculating morphology to boost production, but also for understanding mechanism underlying c-di-GMP biosynthesis and degradation in the bacterium.

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In-situ detoxification strategies to boost bioalcohol production from lignocellulosic biomass

Cited by 28 publications

References 254 publications

Optimized conversion of wheat straw into single cell oils by Yarrowia lipolytica and Lipomyces tetrasporus and synthesis of advanced biofuels

Optimized conversion of wheat straw into single cell oils by Yarrowia lipolytica and Lipomyces tetrasporus and synthesis of advanced biofuels

Bioethanol Production from Lignocellulosic Biomass—Challenges and Solutions

Intracellular accumulation of c-di-GMP and its regulation on self-flocculation of the bacterial cells from Zymomonas mobilis

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