In Situ Embedding Hydrogen‐Bonded Organic Frameworks Nanocrystals in Electrospinning Nanofibers for Ultrastable Broad‐Spectrum Antibacterial Activity

Abstract

In the event of a public health crisis, highly effective and sustainable antimicrobial materials and equipment will be urgently needed. Here, the preparation is reported by electrospinning of broad-spectrum antibacterial nanofibers embedded in a photoactive hydrogen-bonded organic framework (HOF) of rod-like nanocrystals ≈60 nm in length. The resulting HOF@PVDF-HFP nanofibers maintain excellent tensile and breathability characteristics while shielding HOF nanocrystals against acid and alkali corrosion. A series of nanofibers embedded with different amounts and types of HOF nanocrystals are prepared to optimize their efficiency of singlet oxygen ( 1 O 2 ) generation. The 0.5 wt.

Hydrogen-bonded organic frameworks: new horizons in biomedical applications

“…Li's group reported a novel electrospinning preparation of nanofibers embedded in HOF nanocrystals for photoactive broad-spectrum antibacterial activity. 35 Different from surface decoration, the direct electrospinning produced a single continuous nanofiber with the HOF nanocrystals, which showed excellent tensile property, breathability and stability. Based on the 1 O 2 generation efficiency, they screened optimal 0.5 wt% nanofibers with HOFs and poly(vinylidene fluoride- co -hexafluoro-propylene) (HOF-101-F@PVDF-HFP) for killing diversified pathogens.…”

Functional Composite Materials Based on Hydrogen-Bonded Organic Frameworks

“…Schematic showing the preparation of antibacterial HOF@PVDF-HFP nanofibers and the antibacterial mechanism. Reproduced with permission from ref . Copyright 2023 Wiley-VCH.…”

Enhancing the catalytic efficiency and stability of photoenzymes using hydrogen-bonded organic framework material HOF-101

“…11,14,15 Therefore, it has been reported that HOF-101 has been applied to the photocatalytic reduction of carbon dioxide, photoelectric catalysis, and immobilized enzymes. 16,17 Although HOFs have so many advantages, they have not been reported in the field of photoenzyme catalysis. We envision that in the mesoporous microenvironment of HOF-101, photocatalysts and enzymatic catalysts are organized in a reasonable space by one-pot in situ entrapment to accelerate photoenzyme-catalyzed reactions.…”