In situ evaluation of spatiotemporal distribution of doxorubicin from Drug-eluting Beads in a tissue mimicking phantom

Caine, Marcus; Bian, Shuning; Tang, Yiqing; García, Pedro López; Henman, Alexander; Dreher, Matthew R.; Daly, Dan; Carlisle, Robert; Stride, Eleanor; Willis, S.; Lewis, Andrew L.

doi:10.1016/j.ejps.2021.105772

Cited by 7 publications

(9 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Facsimiles were synthesized using hydrogel beads of alginate, a natural polysaccharide commonly used in biomaterial applications of drug release and ophthalmology [ 46 , 47 , 48 ]. Facsimiles were produced with an approximate diameter of 3 mm to model the adult murine eye and were synthesized by mixing solutions of sodium alginate (Cat.…”

Section: Methodsmentioning

confidence: 99%

A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells

2022

View full text Add to dashboard Cite

Millions of adults are affected by progressive vision loss worldwide. The rising incidence of retinal diseases can be attributed to damage or degeneration of neurons that convert light into electrical signals for vision. Contemporary cell replacement therapies have transplanted stem and progenitor-like cells (SCs) into adult retinal tissue to replace damaged neurons and restore the visual neural network. However, the inability of SCs to migrate to targeted areas remains a fundamental challenge. Current bioengineering projects aim to integrate microfluidic technologies with organotypic cultures to examine SC behaviors within biomimetic environments. The application of neural phantoms, or eye facsimiles, in such systems will greatly aid the study of SC migratory behaviors in 3D. This project developed a bioengineering system, called the μ-Eye, to stimulate and examine the migration of retinal SCs within eye facsimiles using external chemical and electrical stimuli. Results illustrate that the imposed fields stimulated large, directional SC migration into eye facsimiles, and that electro-chemotactic stimuli produced significantly larger increases in cell migration than the individual stimuli combined. These findings highlight the significance of microfluidic systems in the development of approaches that apply external fields for neural repair and promote migration-targeted strategies for retinal cell replacement therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells

2022

View full text Add to dashboard Cite

show abstract

“…9–12 The inadequacy of suitable in vitro hepatic tumor models for evaluating the therapeutic effects and potential limitations of TACE has greatly impeded the advancement of any interventional therapy. 13–15…”

Section: Introductionmentioning

confidence: 99%

Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation

et al. 2023

View full text Add to dashboard Cite

show abstract

“…11 Agarose has a long history of applications in biomedical research particularly for DNA gel electrophoresis and continues to be applied as a model hydrogel system. [24][25][26] It consists of an uncharged linear polysaccharide extracted from red algae, made from monomer units of D-galactose and 3,6-anhydro-L-galactose. 27 Gels form at temperatures around 35 1C and at concentrations as low as 0.1%, 27 with commercial reagents selected for ''high'' and ''low'' gelling temperatures.…”

Section: Introductionmentioning

confidence: 99%