In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapy

Abstract

As one of the common reactive oxygen species, H2O2 has been widely used for combating pathogenic bacterial infections. However, the high dosage of H2O2 can induce undesired damages to normal tissues and delay wound healing. In this regard, peroxidase‐like nanomaterials serve as promising nanozymes, thanks to their positive promotion toward the antibacterial performance of H2O2, while avoiding the toxicity caused by the high concentrations of H2O2. In this work, ultrasmall Au nanoparticles (UsAuNPs) are grown on ultrathin 2D metal–organic frameworks (MOFs) via in situ reduction. The formed UsAuNPs/MOFs hybrid features both the advantages of UsAuNPs and ultrathin 2D MOFs, displaying a remarkable peroxidase‐like activity toward H2O2 decomposition into toxic hydroxyl radicals (·OH). Results show that the as‐prepared UsAuNPs/MOFs nanozyme exhibits excellent antibacterial properties against both Gram‐negative (Escherichia coli) and Gram‐positive (Staphylococcus aureus) bacteria with the assistance of a low dosage of H2O2. Animal experiments indicate that this hybrid material can effectively facilitate wound healing with good biocompatibility. This study reveals the promising potential of a hybrid nanozyme for antibacterial therapy and holds great promise for future clinical applications.

TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2

“…However, the concentration of Ag-TiO 2 SAN converts free radicals is not enough to kill host cells. Cellular viability is also not affected by other nanomaterials with peroxidase-like activity at appropriate concentrations [56] , [57] .…”

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

“…In addition, POD and OXD mimics were verified to catalyze producing harmful ROS, ranging from H 2 O 2 , superoxide, hydroxyl radicals to other small reactive molecules [27]. Hence, metal-and metal oxide-based nanozymes (e.g., V 2 O 5 [368], CuO [369], CeO 2 [370], Au/MOF [371], and Tb 4 O 7 [372]) have been gradually regarded as promising bactericides. For example, Fe 3 O 4 NPs with POD-like properties could decompose H 2 O 2 to generate toxic • OH for bacterial infections treatment [373].…”

Anti-bacterial activity of gold nanocomposites as a new nanomaterial weapon to combat photogenic agents: recent advances and challenges

“…The formed nanocomposites exhibited acceptable peroxidase-like activity and acted as a valuable antibacterial agent against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria. 58 Green synthesis methods were applied and showed good activity against some Gram-negative bacterial strains. 59 Good antibacterial activity was described from MnFe 2 O 4 @SiO 2 @Au nanocomposites against P. aeruginosa, K. pneumoniae and Proteus mirabilis bacteria.…”