In situ formation of bioactive calcium titanate coatings on titanium screws for medical implants

Zhu, Yinhui; Wang, Xiaokang; Zhou, Yilong; Zhao, Cuilian; Yuan, Jianmin; Wu, Zhenjun; Wu, Song; Wang, Shuangyin

doi:10.1039/c6ra06597j

Cited by 22 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to a coating with hydroxyapatite, which does not form an intimate connection with the titanium and shows delamination and unpredictable biodegradation [ 70 , 71 , 72 ], with the consequence of loose implants, the calcium titanate even preserves the surface architecture and roughness of the implant [ 73 ]. Several authors describe the benefit of a calcium titanate layer on titanium implants in cell culture experiments [ 31 , 74 , 75 , 76 , 77 ], in femoral condyle [ 77 , 78 ], and tibia [ 73 ] of rabbits. Unfortunately, we do not see any significant differences in our experiments between the coated and uncoated implants.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy

et al. 2020

View full text Add to dashboard Cite

The biocompatibility of a cast porous and with a calcium titanate reaction layer functionalized titanium alloy (Ti-6Al-7Nb) was tested by means of cell culture, and a small (rat) and large animal (sheep) model. The uncoated titanium material served as a control. In-vitro tests included the validation of osteoblast-like cells attached to the surface of the material with scanning electron microscopy and immunofluorescence of cytoskeletal actin as well as their osteogenic development, the ability to mineralize, and their vitality. Following the in-vitro tests a small animal (rat) and big animal (sheep) model were accomplished by inserting a cylindrical titanium implant into a drill hole defect in the femoral condyle. After 7, 14, and 30 days (rat) and 6 months (sheep) the condyles were studied regarding histological and histomorphometrical characteristics. Uncoated and coated material showed a good biocompatibility both in cell culture and animal models. While the defect area in the rat is well consolidated after 30 days, the sheep show only little bone inside the implant after 6 months, possibly due to stress shielding. None of the executed methods indicated a statistically significant difference between coated and uncoated material.

show abstract

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Calcium titanate (CaTiO 3 ) has gained extensive attention in many biomaterial-related works as a promising bioactive ceramic, primarily due to its higher bone tissue biocompatibility in comparison to pure titanium (Ti) and its alloys, and given its positive surface charge which resembles electrical properties of natural bone 2) . Up to date, several reports proved both, in vitro and in vivo, an augmented and stable biochemical bonding between CaTiO 3 surfaces and bone tissue in addition to an accelerated osseointegration to CaTiO 3 -coated implants [3][4][5][6] . Furthermore, it was shown that aforementioned bone bonding to CaTiO 3 might be increased either through micro-and nanostructuration of CaTiO 3 or by combining this material with carbon in diff erent forms 7,8) .…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies of our group compared osteoblastic cell response against CaTiO 3 compounded with amorphous carbon (CaTiO 3 -aC), CaTiO 3 -CaCO 3 composites, hydroxyapatite and commercial CaTiO 3 . Results revealed that the presence of CaCO 3 in CaTiO 3 increases proliferation, diff erentiation and mineralization of bone marrow stromal cells in comparison to commercial CaTiO 3 and hydroxyapatite.…”

Section: Introductionmentioning

confidence: 99%

“…In order to maximize the advantages of CaTiO 3 -CaCO 3 composites, here we synthesize the aforementioned compounds through an alkoxide method. Up to date, bioactive compounds like CaTiO 3 and CaCO 3 have been separately formed by methods such as plasma spraying, sputtering, sol-gel or complex hydrothermal techniques which either require expensive equipment, strict control of precursor hydrolysis or multiple processing steps 3) . In this work, the alkoxide method is followed by sintering.…”

Section: Introductionmentioning

confidence: 99%

“…In this work, the alkoxide method is followed by sintering. The former technique aims to simultaneously form CaTiO 3 and CaCO 3 , whereas the latter provides optimal mechanical properties for hard tissue environments. In addition, different sintering times are here used to regulate CaCO 3 formation within CaTiO 3 bulk.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In Vitro Efficacy of CaCO3 Content in CaTiO3– CaCO3 Composites for Bone Growth

Rodrı́guez

Sánchez

Felice

et al. 2018

J. Hard Tissue Biology.

View full text Add to dashboard Cite

The eff ect of CaTiO 3 compounded with diff erent amounts of CaCO 3 on osteoblastic KUSA/A1 cells was evaluated. CaTiO 3 -CaCO 3 composites were obtained by alkoxide method, a simple, low-cost and reproducible technique used for largescale production of material. The content of CaCO 3 in our samples was controlled by varying the sintering time of the overall process. Composite morphology was assessed by scanning electron microscopy (SEM) showing particles with sizes ranging from100 to 500 nm. The presence of CaCO 3 was revealed by XRD and thermogravimetric analyses, which suggested that samples treated at 650ºC for 30 min contained higher amounts of CaCO 3 than samples treated for 2 and 10 h. Additionally, in vitro studies demonstrated that CaTiO 3 -CaCO 3 composites sintered for 30 min induced augmented cell proliferation and mineralization in comparison to composites sintered for longer periods of time. Hence, our fi ndings clearly suggest that the amount of CaCO 3 within CaTiO 3 -CaCO 3 composites exerts a critical eff ect on osteoblastic cells response. Enhanced bone regeneration could be achieved by increasing the content of CaCO 3 within the composites, thus establishing CaTiO 3 -CaCO 3 as a promising material for bone augmentation procedures in dental fi eld.

show abstract

Structural characterization, mechanical, and electrochemical studies of hydroxyapatite‐titanium composite coating fabricated using electrophoretic deposition and reaction bonding process

et al. 2019

View full text Add to dashboard Cite

In the present work, hydroxyapatite (HA)-titanium (Ti, 20 wt%) composite coating was coated on NiTi alloy substrate by EPD (electrophoretic deposition) process.Before applying the coating, the HA powder was composed with Ti powder using a ball milling process. Influence of the ball milling time on morphology and phase structure of HA-Ti powder was evaluated using TEM and XRD analysis. After composing the HA particles with Ti, the HA-Ti composite powders were coated on the NiTi substrate by the EPD process in an n-butanol medium for 2 min, with the applied voltage of 60 V. XRD and SEM analysis were utilized to evaluate the phase analysis and morphology of the coatings. Mechanical and electrochemical characteristic of the coatings were also assessed using the micro-indentation, micro-scratch, and polarization tests, respectively. The results revealed that the milling process time had a significant influence on reaction bonds and optimum mixing time was 4 hr. Micro-hardness of the HA-Ti composite coating (304 HV) was substantially higher than the HA coating (72 HV). Also, as the HA coating was composed with Ti particles, the amount of force (in the micro-scratch test) required for detaching the coating from the NiTi substrate increased from 7.1 to 17.8 N. The polarization results showed that the HA-Ti composite coating had a higher electrochemical resistance compared with the HA coating. Corrosion resistance of the NiTi alloy coated with HA increased from 133 kΩ. cm 2 to 2,720 kΩ.cm 2 after composed with the Ti particles.

show abstract

In situ formation of bioactive calcium titanate coatings on titanium screws for medical implants

Abstract: The special morphology of CaTiO3 coatings synthesized by a facile hydrothermal method improved titanium's in vitro and in vivo biocompatibility.

Cited by 22 publications

References 26 publications

In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy

In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy

<i>In Vitro</i> Efficacy of CaCO<sub>3</sub> Content in CaTiO<sub>3</sub>– CaCO<sub>3</sub> Composites for Bone Growth

Structural characterization, mechanical, and electrochemical studies of hydroxyapatite‐titanium composite coating fabricated using electrophoretic deposition and reaction bonding process

Contact Info

Product

Resources

About