In situ formation of ferrous sulfide in glycyrrhizic acid hydrogels to promote healing of multi-drug resistant Staphylococcus aureus-infected diabetic wounds

Xu, Zhuobin; Xu, Zhihong; Gu, Jiake; Zhou, Juan; Sha, Gengyu; Huang, Ying; Wang, Tong; Fan, Lei; Zhang, Yanfeng; Xi, Juqun

doi:10.1016/j.jcis.2023.07.141

Cited by 20 publications

(4 citation statements)

References 46 publications

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“…Early studies have shown that LA and LF had good antimicrobial activity. Low-concentration LA solution (0.03-0.25 mg/mL) inhibited the Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Bacterium aeruginosa expend effectively [38,39]. LF inhibited Staphylococcus aureus, usarium graminearum and Listeria monocytogenes expend [40][41][42].…”

Section: Antioxidant Activity Of Licorice Extractsmentioning

confidence: 99%

Three Licorice Extracts’ Impact on the Quality of Fresh-Cut Sweet Potato (Ipomoea batatas (L.) Lam) Slices

Xu,

Zhang,

Jin

et al. 2024

Foods

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The quality of fresh-cut produce, particularly sweet potatoes, is crucial for their value. Licorice extract is an optional additive in fresh-cut sweet potatoes. This study examined the impact of three licorice extracts (licorice acid, LA; licorice flavonoids, LF; and licorice polysaccharides, LP) on the quality of fresh-cut sweet potato slices (FCSPSs) for one week of storage. After one week of storage, the extracts showed varying effects on FCSPSs. LA and LF treatments reduced the area proportion of browning (APB), while LP treatments increased APB and decreased L* values. Antioxidant experiments revealed that LP treatments increased PPO and POD activity while reducing SOD activity. The concentrations of the three licorice extracts showed a strong negative correlation with SOD activity. In conclusion, LP harmed the appearance and antioxidant qualities of FCSPSs. LA and LF may be suitable additive components for FCSPSs, and 30 mg/mL LA and LF treatments were found to maintain the appearance and texture quality of FCSPSs during storage. Therefore, careful consideration should be given when using LP as a food additive for FCSPSs.

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Section: Antioxidant Activity Of Licorice Extractsmentioning

confidence: 99%

Three Licorice Extracts’ Impact on the Quality of Fresh-Cut Sweet Potato (Ipomoea batatas (L.) Lam) Slices

Xu,

Zhang,

Jin

et al. 2024

Foods

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“…Fe doping endows carbon dots with photo-enhanced peroxidase-like activity, which leads to the generation of heat and ROS to kill gram-positive and gram-negative bacteria. Iron ion incorporated hydrogel (illustrated in Figure 6) that could accelerate the infected diabetic wound healing through the released ferrous Fe ions that could induce bacterial death [53].…”

Section: Iron Ionsmentioning

confidence: 99%

Clays and Wound Healing

Tian,

Wang,

Huang

et al. 2024

Materials

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Aluminosilicates, such as montmorillonite, kaolinite, halloysite, and diatomite, have a uniform bidimensional structure, a high surface-to-volume ratio, inherent stiffness, a dual charge distribution, chemical inertness, biocompatibility, abundant active groups on the surface, such as silanol (Si-OH) and/or aluminol (Al-OH) groups. These compounds are on the list of U.S. Food and Drug Administration-approved active compounds and excipients and are used for various medicinal products, such as wound healing agents, antidiarrheals, and cosmetics. This review summarizes the wound healing mechanisms related to the material characteristics and the chemical components. Numerous wound dressings with different active components and multiple forms have been studied. Then, medicinal mineral resources for use in hemostatic materials can be developed.

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“…Consequently, the FeS/GA hydrogels efficiently eradicated bacteria and regulated the inflammatory microenvironment, promoting enhanced MRSA infected diabetic wound healing. 122 In addition, Ge et al 119 designed the microenvironment-responsive self-delivery GOx@MnS NPs, in which Mn 2+ reacted with H 2 O 2 to generate hydroxyl radicals for exerting bactericidal effect ( Figure 4(d) ), the release of H 2 S facilitated macrophage polarization simultaneously, and these two mechanisms synergistically contributed to the promotion of diabetic wound healing. In summary, antibacterial hydrogels present notable advantages in diabetic wound care, providing localized and controlled release of antibacterial agents, efficient wound management, and high biocompatibility.…”

Section: The Complex Microenvironment Of Diabetic Wounds and The Cust...mentioning

confidence: 99%

Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

Zhao,

et al. 2024

J Tissue Eng

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The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. The intricate healing mechanisms of diabetic wounds are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels of reactive oxygen species (ROS), ischemia, impaired vascularization, and altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for diabetic wound treatment owing to their exceptional biocompatibility and resemblance to the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize the microenvironment alterations occurring in the diabetic wounds, aiming to provide a comprehensive understanding of its pathogenesis, then a comprehensive classification of recently developed hydrogels will be presented, encompassing properties such as hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion of angiogenesis, pH responsiveness, and more. The primary objective is to offer a valuable reference for repairing diabetic wounds based on their unique microenvironment. Moreover, this paper outlines potential avenues for future advancements in hydrogel dressings to facilitate and expedite the healing process of diabetic wounds.

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In situ formation of ferrous sulfide in glycyrrhizic acid hydrogels to promote healing of multi-drug resistant Staphylococcus aureus-infected diabetic wounds

Cited by 20 publications

References 46 publications

Three Licorice Extracts’ Impact on the Quality of Fresh-Cut Sweet Potato (Ipomoea batatas (L.) Lam) Slices

Three Licorice Extracts’ Impact on the Quality of Fresh-Cut Sweet Potato (Ipomoea batatas (L.) Lam) Slices

Clays and Wound Healing

Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

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