In situ forming acyl-capped PCLA–PEG–PCLA triblock copolymer based hydrogels

Sandker, Maria J.; Petit, Arnaud; Redout, Everaldo M.; Siebelt, Michiel; Müller, Benno; Bruin, Peter de; Meyboom, R.H.B.; Vermonden, Tina; Hennink, Wim E.; Weinans, Harrie

doi:10.1016/j.biomaterials.2013.07.046

Cited by 64 publications

(49 citation statements)

References 56 publications

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“…These 3D networks can be fabricated via physical and/or chemical crosslinking reactions (see Glossary, Box 1) of various natural materials, such as collagen, fibrinogen, dextran and HA, as well as synthetic polymers, e.g. polyethylene glycol (PEG) and its derivatives (Park et al, 2011;Koehler et al, 2013;Sandker et al, 2013;Stahl et al, 2014;Tokuda et al, 2014). In addition, hydrogels can be easily tailored with bioactive molecules (Mosiewicz et al, 2013), and their physicochemical properties are easily controlled (Tibbitt et al, 2013).…”

Section: Engineered Cellular Constructs: Creating New Vasculature In mentioning

confidence: 99%

Harnessing developmental processes for vascular engineering and regeneration

Park

Gerecht

2014

Development

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The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms via the dual processes of vasculogenesis and angiogenesis, and is regulated at multiple levels: from transcriptional hierarchies and protein interactions to inputs from the extracellular environment. Understanding how vascular formation is coordinated in vivo can offer valuable insights into engineering approaches for therapeutic vascularization and angiogenesis, whether by creating new vasculature in vitro or by stimulating neovascularization in vivo. In this Review, we will discuss how the process of vascular development can be used to guide approaches to engineering vasculature. Specifically, we will focus on some of the recently reported approaches to stimulate therapeutic angiogenesis by recreating the embryonic vascular microenvironment using biomaterials for vascular engineering and regeneration.

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Section: Engineered Cellular Constructs: Creating New Vasculature In mentioning

confidence: 99%

Harnessing developmental processes for vascular engineering and regeneration

Park

Gerecht

2014

Development

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“…For IA drug delivery, mostly the polymers that have proven to be biocompatible were investigated. PLA has been shown to be biocompatible in rabbit knees [61,62], polyethylene glycol (PEG), often combined with other polymers (e.g., polycaprolactone (PCL)) is biocompatible and able to control release characteristics of the incorporated drug [72][73][74][75], however, by far, the most used synthetic polymer is PLGA. This synthetic polymer has a good biocompatibility and is able to incorporate many different types of drugs [29,31,[35][36][37]39,[42][43][44][45][46]50,60,61,[72][73][74][76][77][78][79][80][81][82][83][84].…”

Section: Polymersmentioning

confidence: 99%

“…Another method to deal with burst release was provided by Chen et al, by loading brucine in a chitosan microsphere and dispersed that microsphere in a chitosan hydrogel [95]. A more investigative approach was used by Sandker et al, who incorporated 2-(2',3',5',-triiodobenzoyl) moieties (TIB) to make their poly(ε-caprolactone-colactide)-b-poly(ethylene glycol)-bpoly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA) hydrogel radiopaque for long term in vivo visualization [75].…”

Section: Hydrogelsmentioning

confidence: 99%

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

et al. 2014

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Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common causes of disability in the adult population. Currently applied therapies consist of physical therapy, oral medication, intra-articular injections, and surgical interventions, with the main goal being to reduce pain and improve function and quality of life. Intra-articular (IA) administration of drugs has potential benefits in OA treatment because it minimizes systemic bioavailability and side effects associated with oral administration of drugs without compromising the therapeutic effect in the joint. However, IA drug residence time is short and there is a clinical need for a vehicle that is able to provide a sustained release long enough for IA therapy to fulfill its promise. This review summarizes the use of different polymeric systems and the incorporated drugs for IA drug delivery in the osteoarthritic joint with a primary focus on clinical needs and opportunities.

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“…[1][2][3][4][5][6][7] Hydrogels can be prepared from a variety of materials, including polymers, 8,9 small molecules, 10 and colloidal particles, 11 via either covalent bonding or physical interactions. Since one of the main applications of hydrogel is in the pharmaceutical and medical fields, biodegradable and biocompatible materials, such as hyaluronic acid, 12 peptide, 10,13 and DNA, [14][15][16][17][18][19][20][21][22][23][24][25] have received considerable attention in the preparation of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Effects of chain flexibility on the properties of DNA hydrogels

et al. 2016

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The effect of chain rigidity on the mechanic properties of DNA hydrogels was studied. Counterintuitively, the hydrogel formed by mainly flexible chains exhibited better stability, stretchability, and much mechanical properties than the hydrogel containing only rigid chains. Calculations showed that the crosslinking ratio in the hydrogel formed by flexible chains was about twice that of the hydrogel formed by rigid chains under the same conditions. We attributed this to the ease of conformational adjustment of flexible chains. Incorporation of 25% rigid chains further improved the performance of DNA hydrogel by shrinking the pore size and tuning its distribution.

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In situ forming acyl-capped PCLA–PEG–PCLA triblock copolymer based hydrogels

Cited by 64 publications

References 56 publications

Harnessing developmental processes for vascular engineering and regeneration

Harnessing developmental processes for vascular engineering and regeneration

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

Effects of chain flexibility on the properties of DNA hydrogels

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