In situ gelation of thiolated poly(aspartic acid) derivatives through oxidant-free disulfide formation for ophthalmic drug delivery

Szilágyi, Barnabas Áron; Kiss, Emil W.; Budai-Szűcs, Mária; Misra, Anil; Csányi, Erzsébet; László, Krisztina; Szilágyi, András

doi:10.1016/j.colsurfb.2023.113254

Cited by 5 publications

(1 citation statement)

References 49 publications

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“…Hydrogels were three-dimensional networks of hydrophilic polymers that could swell in water and hold a large amount of water (up to 99%) while maintaining the structure due to chemical or physical cross-linking . In addition, hydrogels also had good biocompatibility, biodegradability, high durability, nontoxicity, etc. − They were widely used in biomedical fields such as drug release, − medical dressing, − tissue regeneration, bone repair, − contact lenses etc., which were one of the most promising medical materials in the future . Polysaccharides were the most suitable hydrogel-forming materials due to biocompatibility, enzymatic degradation, high durability, and not-toxicity. − Alginates were unbranched polysaccharides linked by 1 → 4 glycosidic bonds composed of β- d -mannuronic acid (M) and its C-5 epimer, α- l -guluronic acid (G) .…”

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confidence: 99%

Continuous and Controllable Preparation of Sodium Alginate Hydrogel Tubes Guided by the Soft Cap Inspired by the Apical Growth of the Plant

Wang,

et al. 2024

ACS Appl. Mater. Interfaces

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Hydrogel tubes made of sodium alginate (SA) have potential applications in drug delivery, soft robots, biomimetic blood vessels, tissue stents, and other fields. However, the continuous preparation of hollow SA hydrogel tubes with good stability and size control remains a huge challenge for chemists, material scientists, and medical practitioners. Inspired by the plant apical growth strategy, a new method named soft cap-guided growth was proposed to produce SA hydrogel tubes. Due to the introduction of inert low gravity substances, such as air and heptane, into the extrusion needle in front of calcium chloride solution to form a soft cap, the SA hydrogel tubes with controllable sizes were fabricated rapidly and continuously without using a template through a negative gravitropism mechanism. The SA hydrogel tubes had good tensile strength, high burst pressure, and good cell compatibility. In addition, hydrogel tubes with complex patterns were conveniently created by controlling the motion path of a soft cap, such as a rotating SA bath or magnetic force. Our research provided a simple innovative technique to steer the growth of hydrogel tubes, which made it possible to mass produce hydrogel tubes with controllable sizes and programmable patterns.

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