In-situ label-free temperature-compensated DNA hybridization detection with a fiber-optic interferometer and a fiber Bragg grating for microfluidic chip

Hu, Xu-guang; Zhao, Yong; Peng, Yun; Chen, Xiao-ming; Wang, Lu-feng; Lin, Zi-ting; Zhao, Jian; Hu, Sheng

doi:10.1016/j.bios.2023.115703

Cited by 10 publications

(1 citation statement)

References 36 publications

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“…Temperature is a pivotal parameter in the growth and development of organisms. It significantly influences enzymatic activities, cellular metabolism, and reaction kinetics, making temperature control an indispensable aspect of biological experiments [6,7]. Accurate temperature regulation ensures that experimental conditions are maintained consistently, which is crucial for obtaining reliable and reproducible results.…”

Section: Introductionmentioning

confidence: 99%

Target Tracking Two Degrees of Freedom State Feedback Control for Continuous Flow Microfluidic Chips Temperature Controller

Jiang,

Liu,

Xue

et al. 2024

Processes

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Microfluidic chips represent a cutting-edge technology for manipulating fluids within micrometer-scale spaces and are gradually becoming a new favorite platform in life science research. Precise and fast zonal temperature control is essential for accelerating biological experiments. However, current multi-channel temperature controllers typically rely on multiple channel sets to achieve single set-point control, which results in discrepancies between the fluid temperature distribution and sensor temperature due to the distributed temperature field in the fluid channel. To estimate the actual temperature and implement gradient temperature control, this paper introduces an extension of the target tracking (TT) two degrees of freedom (2DOF) state feedback control (SFC) method, followed by a presentation of simulation and experimental results. Through comparisons with an enhanced PID system in both simulation and experimentation, the paper demonstrates an 8.96% reduction in the maximum temperature difference across different regions and a 27.89% decrease in the time taken to reach various temperatures. This solution effectively addresses the existing challenges in temperature control for microfluidic chips, offering a more precise and stable control within the desired temperature range.

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Section: Introductionmentioning

confidence: 99%