In situ niosome forming maltodextrin proniosomes of candesartan cilexetil: In vitro and in vivo evaluations

Yüksel, Nilüfer; Bayındır, Zerrin Sezgin; Aksakal, Elif; Özçeli̇kay, A.Tanju

doi:10.1016/j.ijbiomac.2015.10.019

Cited by 48 publications

(31 citation statements)

References 25 publications

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“…Proniosomes are produced by coating a thin layer of non-ionic surfactant on a water-soluble carrier (2,11,19). To make proniosomes, the water-soluble carriers need to be non-toxic, safe, free-flowing and have good water solubility to allow easy hydration.…”

Section: Types Of Specialized Niosomes 211 Proniosomesmentioning

confidence: 99%

“…To make proniosomes, the water-soluble carriers need to be non-toxic, safe, free-flowing and have good water solubility to allow easy hydration. Maltodextrin, sorbitol, mannitol, glucose monohydrate, lactose monohydrate, and sucrose stearate have been used to prepare proniosomes (2,19). Proniosomes present in a dry powder form and have several advantages over the conventional niosomes such as better stability, less likely to form aggregates as well as reduced drug leakage (3).…”

Section: Types Of Specialized Niosomes 211 Proniosomesmentioning

confidence: 99%

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Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Chen

Hanning

Falconer

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

331

176

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Types Of Specialized Niosomes 211 Proniosomesmentioning

confidence: 99%

Section: Types Of Specialized Niosomes 211 Proniosomesmentioning

confidence: 99%

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Chen

Hanning

Falconer

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

331

176

View full text Add to dashboard Cite

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“…Niosomes based formulation for enhanced oral bioavailability of candesartan cilexetil [15] Table 1. Presentation of liposome-type systems.…”

Section: Main Components Illustrative Applicationmentioning

confidence: 99%

General Perception of Liposomes: Formation, Manufacturing and Applications

Nkanga¹,

Bapolisi²,

Okafor³

et al. 2019

Liposomes - Advances and Perspectives

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Liposomes are currently part of the most reputed carriers for various molecular species, from small and simple to large and complex molecules. Since their discovery, liposomes have been subject to extensive evolution, in terms of composition, manufacturing and applications, which led to several openings in both basic and applied life sciences. However, most of the advances in liposome research have been more devoted to launching new developments than improving the existing technology for potential implementation. For instance, the evolution of the conventional lipid hydration methods to novel microfluidic technologies has permitted upscale production, but with increase in manufacturing cost and persistent use of organic solvents. This chapter intends to present general concepts in liposome technology, highlighting some longstanding bottlenecks that remain challenging to the preparation, characterization and applications of liposomal systems. This would enhance the understanding of the gaps in the field and, hence, provide directions for future research and developments.

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“…Oral administration is a most preferred route with high patient compliance. However, bioavailability is poor progress observed reasons behind were poor solubility of drug candidate followed by less absorption [2]. Less aqueous solubility is the major drawback encountered with the formulation design of new chemical moiety [3].…”

Section: Introductionmentioning

confidence: 99%

Recent Update on Proniosomal Gel as Topical Drug Delivery System

Rajkumar

Sastri

et al. 2019

Asian J Pharm Clin Res

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An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

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In situ niosome forming maltodextrin proniosomes of candesartan cilexetil: In vitro and in vivo evaluations

Cited by 48 publications

References 25 publications

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

General Perception of Liposomes: Formation, Manufacturing and Applications

Recent Update on Proniosomal Gel as Topical Drug Delivery System

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