In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS‐Mediated Anticancer Therapy

Abstract

The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic therapy (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, we reported an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor to integrate the synergistic effect of PDT/CDT for enhancing ROSmediated pancreatic ductal adenocarcinoma treatment. HPPH photosensitizer was hybridized within the framework of HMON via an "in situ framework growth" approach. Then, the hollow cavity of HMONs was exploited as a nanoreactor for "in situ polymerization" to synthesize the polymer containing thiol groups, thereby enabling the immobilization of ultrasmall gold nanoparticles, which behave like glucose oxidase-like nanozyme, converting glucose into H 2 O 2 to provide self-supplied H 2 O 2 for CDT. Meanwhile, Cu 2+ -tannic acid complexes were further deposited on the surface of HMONs (HMON-Au@Cu-TA) to initiate Fenton-like reaction to covert the self-supplied H 2 O 2 into •OH, a highly toxic ROS. Finally, collagenase (Col), which can degrade the collagen I fiber in the extracellular matrix (ECM), was loaded into HMON-Au@Cu-TA to enhance the penetration of HMONs and O 2 infiltration for enhanced PDT. This study provides a good paradigm for enhancing ROS-mediated anti-tumor efficacy. Meanwhile, this research offers a new method to broaden the application of silica based nanotheranostics.

Solid wetting-layers in inorganic nano-reactors: the water in imogolite nanotube case

“…[1][2][3][4][5][6][7][8][9] Driven by the oen unexpected and appealing effects of nano-connement on chemical and physical properties, development of nano-reactors towards rational control of chemical reactivity by design has turned into one of the most thriving areas of contemporary research in chemistry. [10][11][12][13][14][15][16][17][18][19][20][21] For such a control to be truly rational, accurate understanding of the atomistic details of a given reaction in terms of stoichiometry, structure and interactions is required, together with quantication of the mutual effects that the nano-conned species and the nano-conning reactor exert on one another. However, to our knowledge, this has not been achieved to date with simultaneous resolution of the systems' stoichiometry, structure and dynamics.…”

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H2S-amplified synergistic therapy

“…The efficacy of PDT suffers daunting challenges due to the intrinsic hypoxia environment of tumor tissue 2 . A variety of strategies have been devoted to tackle this challenge, including direct supply of oxygen during PDT 3 - 6 or combining other oxygen-independent therapies to promote antitumor outcomes 7 - 10 . Alternatively, the use of a hypoxia-activated prodrug, tirapazamine (TPZ), enables high toxicity to malignant tumor cells with intrinsic hypoxia, while showing negligible inhibition to normoxia cells 11 , 12 .…”

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

“…We demonstrated in this paper that nanomaterials with peroxidase‐like properties inhibited tumor growth by inducing a novel form of RAS‐activated oxidative cell death. Since nanomaterials and nanotechnology have been increasingly used for cancer diagnosis [ 20 ] and treatment, [ 21–25 ] their general mechanisms and bioeffects on tumor cells would have exciting implications for anticancer nanomedicine development.…”