In situ preparation of poly(l-lactic acid-co-glycolic acid)/hydroxyapatite composites as artificial bone materials

Takeoka, Yuko; Hayashi, Miki; Sugiyama, Nami; Yoshizawa‐Fujita, Masahiro; Aizawa, Mamoru; Rikukawa, Masahiro

doi:10.1038/pj.2014.121

Cited by 27 publications

(21 citation statements)

References 34 publications

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“…These phosphonic acid monomers exhibit minimal adhesion to hard dental tissues [27]. Its low binding strengths are believed to be caused by its poor solubility in water and a non-flexible spacer alkylene group in its molecular structures, although it has an effective phosphonic acid group.…”

Section: Discussionmentioning

confidence: 99%

“…In 1974, Anber and Farley proposed vinylphosphonic acid (VPA) and vinylbenzylphosphonic acid (VBPA) for attachment to tooth structure [27]. These phosphonic acid monomers exhibit minimal adhesion to hard dental tissues [27].…”

Section: Discussionmentioning

confidence: 99%

“…Its low binding strengths are believed to be caused by its poor solubility in water and a non-flexible spacer alkylene group in its molecular structures, although it has an effective phosphonic acid group. During the last decade, however, interest in the use of phosphonic acid monomers has been Revived by the demonstration of its superior hydrolytic stability with improved bonding performance to hard dental tissues [27].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Estrada

2017

IJRRT

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A descriptive bibliographic review of the evidence provided in indexed articles and other bibliographic sources, such as books, theses and others, has been made. These were analyzed and after checking whether or not they met the inclusion/exclusion criteria of this work, finally were 27 articles of bibliographic review published in a hairpin that goes from 2007 to 2016. IntroductionThe use of metals in dentistry has great therapeutic advantages in many fields of dentistry, such as orthodontics, prostheses, conservative dentistry since its origins and more recently implantology [2]. Likewise, metals can be used on numerous and varied substrates: enamel, dentin, ceramics, resins or other metals [1]. Examples of adhesion of enamel or dentin to metals, orthodontic bands and brackets, or Maryland type adhesive bridges. It may be necessary to attach a metal to ceramics in the case of a metal crown, which by aesthetics will be covered or another metal (such as a cast post) to the metal of the crown and / or ceramics thereof, or even when it is free of metal [4].The first and foremost objective of dental adhesives is the long-lasting attachment to their substrates or adhesives, whether hard dental tissues or a wide range of materials (some new and others already contaminated when already in the mouth). The adhesive system, already discovered by Bouncoure and Bowen in the 1960s, has meant an improvement in speed, efficiency and convenience by simplifying the joining steps of two bodies of disparate origin and nature and reducing the time in the clinician's working time. The current trend in the development of dental adhesive systems follows the line of self-etch adhesives, multipurpose primers or adhesives that give a strong and durable adhesion indiscriminately to a multitude of adherents that coexist in the oral environment, ranging from tejdios (Enamel and dentin), precious metals (noble), alloys of precious metals and alloys of non-precious metals to dental porcelain, ceramics based on aluminum oxide (alumina) and zirconium-based ceramics [6,7].Do not overlook the many detractors of self-etch adhesives. On the one hand self-etching adhesives are easy to use and less prone to cause postoperative sensitivity. Although on the other hand, AbstractThe use of metals in dentistry presupposes the need for mechanisms of retention or adhesion of the same to different substrates; Such as enamel, dentin, ceramics, old resins and other metals [1].Throughout history these mechanisms have been changing and evolving, from the purely mechanical retention to the present mechanisms of adhesion [2,3]. It is in the decade of the 70 when they begin to develop adhesion materials. Prior to this, retention was basically mechanical, having also evolved from macromechanical retention systems to micromechanical retention systems [3]. It is at the end of the 70 when the first generation of adhesives appears; These monomers were 4-META (4-methacryloyloxyethyl trimellitate anhydride) and 10-MDP (10-methacryloyloxydecyl dihydrogen phosphate). Thes...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Estrada

2017

IJRRT

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“…HAp has also been widely added to PLA matrix and HAp-PLLA composites obtained exhibit superior biological performance [58][59][60][61][62]. Takeoka et al [63] managed to polymerize L-lactide and glycolide in situ and several PLGA/HAp composites with different ratio of L-lactide and glycolide in porous HAp disks were successfully obtained. Scanning electron microscopy result ( Figure 1) indicated that porous HAp was completely full of PLGA after polymerization at 100 ∘ C for 9 days while PLLA/HAp composites were found containing continuous open pores.…”

Section: Synthetic Bone Substitute and Repairmentioning

confidence: 99%

Polylactic Acid Based Nanocomposites: Promising Safe and Biodegradable Materials in Biomedical Field

Sha

Chen

Zhou

et al. 2016

International Journal of Polymer Science

105

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Polylactic acid (PLA) is widely used in biological areas due to its excellent compatibility, bioabsorbability, and degradation behavior in human bodies. Pure polylactic acid has difficulty in meeting all the requirements that specific field may demand. Therefore, PLA based nanocomposites are extensively investigated over the past few decades. PLA based nanocomposites include PLA based copolymers in nanometer size and nanocomposites with PLA or PLA copolymers as matrix and nanofillers as annexing agent. The small scale effect and surface effect of nanomaterials help improve the properties of PLA and make PLA based nanocomposites more popular compared with pure PLA materials. This review mainly introduces different kinds of PLA based nanocomposites in recent researches that have great potential to be used in biomedical fields including bone substitute and repair, tissue engineering, and drug delivery system.

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“…Cortical bone mainly exists in the high load-bearing bones, like tibia and fibula. To repair the damaged sites in these bones, a compressive strength above 150 MPa of the repairing scaffold is generally demanded [12]. Meanwhile, as a candidate to repair bone, the substitute should be porous, or able to provide porosity after implantation [13].…”

Section: Research Articlementioning

confidence: 99%

Optimization of Sintering Conditions for Improvement of Mechanical Property of a-Tricalcium Phosphate Blocks

Iy¹

2016

Glob J Biotechnol Biomater Sci

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Bioactive ceramic materials have been under research as bone substitute for several decades. To repair the high-load bearing bones, mainly cortical bones, there is a need for the substitute to possess comparable mechanical strength to cortical bone, of which the compressive strength ranges between 100 and 230 MPa. Two prevailing bone repairing material, β-tricalcium phosphate (β-TCP, β-Ca 3 (PO 4 ) 2 ) and hydroxyapatite (HAp: Ca 10 (PO 4 ) 6 (OH) 2 ) have been widely researched and sintered into dense blocks to meet the mechanical requirements. α-tricalcium phosphate (α-TCP, α-Ca 3 (PO 4 ) 2 ), a high temperature polymorph of β-TCP, received relatively less attention and α-TCP dense sintered blocks have not been reported yet. In this research, we fabricated α-TCP dense blocks by sintering under various temperatures (1150-1400 °C) and the highest compressive strength was around 230 MPa. Intermediate porous blocks (porosity: 33%) were also fabricated from mixed powder of α-TCP and starch. In vitro properties variation of the intermediate porous blocks were investigated by soaking samples in simulated body fluid (SBF) and the compressive strength was maintained above 100 MPa after soaking for 14 d.

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In situ preparation of poly(l-lactic acid-co-glycolic acid)/hydroxyapatite composites as artificial bone materials

Cited by 27 publications

References 34 publications

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Polylactic Acid Based Nanocomposites: Promising Safe and Biodegradable Materials in Biomedical Field

Optimization of Sintering Conditions for Improvement of Mechanical Property of a-Tricalcium Phosphate Blocks

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