In situ Raman monitoring triazole formation from self-assembled monolayers of 1,4-diethynylbenzene on Ag and Au surfaces via “click” cyclization

Microwave irradiated click reactions on silicon surfaces via derivertization of covalently grafted poly(PEGMA) brushes

“…Especially click chemistry is widely recognized in biomedical applications recently for its reaction in aqueous media and under room temperature. Either acetylene or azide moieties can be conveniently introduced onto solid surfaces [2][3][4][5][6][7][8][9][10][11][12][13][14] or combined with functional or biological molecules [4,6,[15][16][17][18][19][20][21]. Furthermore through click chemistry, a variety of probe molecules can be anchored onto solid surfaces for sensors and biochips.…”

Spectroscopic Tracking of Molecular Transport Junctions Generated by Using Click Chemistry

“…[26] The confocal Raman images (Figure 3b) obtained by integrating the spectral intensity from 1520 to 1620 cm −1 and the bright-field optical image shows the hot spots are localized in the gap. When 2 reacts with the monolayer of 1 through click chemistry, new peaks at 967 and 1010 cm −1 (the triazole ring stretch), [27] 1606 cm −1 (C-C benzene ring stretching of 2 ), and 2198 cm −1 (asymmetric stretching of azide groups) appear, and the peak at 2108 cm −1 disappears (ii of Figure 3c), indicating the click reaction of 1 and 2 proceeded. Furthermore, when 3 reacts with 2 through click chemistry, the relative intensity of the peak at 1606 cm −1 increases (iii of Figure 3c), which confirms the occurrence of the reaction between 3 and 2 .…”

High‐Quality Covalently Grafting Hemoglobin on Gold Electrodes: Characterization, Redox Thermodynamics and Bio‐electrocatalysis

“…An absence of the sharp peak in the region of 2094 cm À1 (representing the free C C group at the surface) in Figure 1 A, indicates that the click reaction proceeded in almost a quantitative yield. Also, the broad peak in the region of~2000 cm À1 of the n(CC) bound band observed in Figure 1 A is blue-shifted to~2230 cm À1 in Figure 1 B [32] . Since the frequency of the azide band is found at 2110 cm À1 , it is not likely that the observed band can be ascribed to the species of the azide.…”

“…Figures 1 A and 1 B are the SERS spectra of DEB and N 3 -PEG-NH 2 -conjugated DEB by the surface click reaction on roughened gold plates, respectively. A sharp and strong peak in the region of~1600 cm À1 represents the free C=C group in benzene at the surface [32] . One of the most prominent differences between Figures 1 A and 1 B is a spectral change of the C C stretching region.…”