In situ reactivity of the electrochemically generated nitro radical anion from nitrendipine with glutathione, adenine and uracil

Núñez‐Vergara, Luis J.; García, F; Domínguez, M.I.; Fuente, José de la; Squella, J. A.

doi:10.1016/0022-0728(94)03647-l

Cited by 32 publications

(31 citation statements)

References 18 publications

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“…In the case of nifedipine (8), 17 nitrendipine (9) 18 and flutamide (10), 16 results provide experimental proof of the significant reactivity of the nitro radical anions toward adenine and uracil and the ability of GSH (7) to behave as a scavenger of the generated nitroradical anion (Eq. 4).…”

Section: Bioreductive Alkylationmentioning

confidence: 91%

“…The latter role is thought to proceed through catechol estrogen metabolites, which can be oxidised to o-quinones that bind to DNA. Synthesis and characterisation of the first estrogen nucleic acid adduct (19) obtained by intermolecular coupling of electrochemically reduced 3,4-estrone-o-quinone (18) and adenine was performed (Scheme 5). 27,28…”

Section: Selected Examplesmentioning

confidence: 99%

“…34 Using mixed solvents, there is a possibility for studying the behaviour of the several classes of compounds in a situation which will be of more biological relevance than a purely aprotic medium. 36,[16][17][18] Also to mimic biological conditions, parallel experiments are held in the presence of different surfactants. 37 On the other hand, non-aqueous aprotic solvents should be better models of membrane environment in which peroxidation processes take place, because both superoxide anion radical and its conjugated acid, the hydroperoxyl radical, are virtually unstable in water and other protic solvents, owing to fast disproportionation.…”

Section: Practical Problems In the Correlation: Choice Of Experimentamentioning

confidence: 99%

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Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Abreu¹,

Ferraz²,

Goulart³

2002

J. Braz. Chem. Soc.

154

124

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Essa revisão resume alguns dos aspectos mais relevantes na correlação entre processos e parâmetros eletroquímicos e atividades biológicas, relacionadas, principalmente, a doenças tropicais e câncer. Apesar da gama de possibilidades e da complexidade da química celular/tecidual/extracelular, é possível racionalizar o papel da eletroquímica em poucas bases teóricas, principalmente: transferência eletrônica -estresse oxidativo, geração eletroquímica in situ de agentes tóxicos diferentes das espécies oxigenadas reativas, interação com endobióticos, com ênfase particular em alquilação biorredutiva e substituição de endobióticos com função em reações de oxi-redução biológicas. O uso de métodos eletroquímicos para a obtenção de mecanismos de ação de drogas e na análise de eventos celulares é também apresentado. Nessas correlações, métodos e/ou parâmetros eletroquímicos exercem papel relevante, porém, não absoluto.This review summarises some of the more relevant achievements in the correlation between electrochemical processes and parameters and bioactive properties, mainly related to cancer and tropical diseases. Despite the broad range of possibilities and the complexity of cell/tissue/extracell chemistry, it is possible to rationalise the role of electrochemistry in few basic theoretical frameworks, mainly, the one based on electron transfer-oxidative stress and in situ generation of toxic species, other than the reactive oxygen species; interaction with endobiotics, with emphasis on bioreductive alkylation and replacement of endobiotics with function in biological redox reactions. The use of electrochemical methods to obtain relevant informations about drugs' mechanism of action and analysis of cellular events is also presented. Electrochemical methods and/or parameters play essential but not absolute roles.

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Section: Bioreductive Alkylationmentioning

confidence: 91%

Section: Selected Examplesmentioning

confidence: 99%

Section: Practical Problems In the Correlation: Choice Of Experimentamentioning

confidence: 99%

See 1 more Smart Citation

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Abreu¹,

Ferraz²,

Goulart³

2002

J. Braz. Chem. Soc.

154

124

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show abstract

“…Furazolidone potentially behaves as a cytotoxic drug [7]. Therefore, trace amounts determination of furazolidone is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Selective and sensitive furazolidone biosensor based on DNA-modified TiO 2 -reduced graphene oxide

Ensafi

Sohrabi

Jafari-Asl

et al. 2015

Applied Surface Science

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“…As a further exploration, the purpose of the current paper is to demonstrate the usefulness of sequential batch/flow operational modes for the containment of unstable radicals, i.e., for the sustenance of the radicals at a pre-determined (mean) concentration level throughout the entire operation. The generation of the nitro-radical anion from nitrendipine (NTD) in certain endobiotic media [8] serves as an example for quantitative illustration. It concerns the formation of the one-electron couple (ArNO 2 /ArNO ÅÀ 2 ) where Ar denotes an appropriate aromatic.…”

Section: Introductionmentioning

confidence: 99%

An application of reactor theory principles to the confinement of electrochemically generated unstable radical ions

Sioda¹,

Fahidy

Frankowska³

2003

Journal of Electroanalytical Chemistry

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In situ reactivity of the electrochemically generated nitro radical anion from nitrendipine with glutathione, adenine and uracil

Cited by 32 publications

References 18 publications

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Selective and sensitive furazolidone biosensor based on DNA-modified TiO 2 -reduced graphene oxide

An application of reactor theory principles to the confinement of electrochemically generated unstable radical ions

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