In situ research and diagnosis of breast cancer by using HOF-ATR-FTIR spectroscopy

Lu, Yanfei; Zhao, Yuan; Yongkang, Zhu; Xu, Xinyu; Yin, Jianhua

doi:10.1016/j.saa.2020.118178

Cited by 13 publications

(9 citation statements)

References 20 publications

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“…In order to overcome this drawback, Zhao and co-workers developed a handheld ATR-hollow optical fibre (ATR-HOF) and connected it to a FTIR spectrometer, which was then applied to the study of articular cartilage, postoperatively ( Figure 10 ) [ 148 ]. This device was later used by Lu et al to study fresh breast samples, collected from 12 patients undergoing BCS, reaching >90% accuracy when discriminating healthy from cancerous areas [ 149 ]. The use of an ATR configuration decreased the contribution of water in the lower wavenumber region, with the water effect becoming neglectable.…”

Section: Resultsmentioning

confidence: 99%

A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

Mamede

Santos

Carvalho

et al. 2021

Cancers

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In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients’ prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic strategies and diagnostic methodologies, beyond prevention. Optical vibrational spectroscopy has been shown to be an ideal diagnostic method for early cancer diagnosis and surgical margins assessment, as a complement to histopathological analysis. Being highly sensitive, non-invasive and capable of real-time molecular imaging, Raman and Fourier transform infrared (FTIR) spectroscopies give information on the biochemical profile of the tissue under analysis, detecting the metabolic differences between healthy and cancerous portions of the same sample. This constitutes tremendous progress in the field, since the cancer-prompted morphological alterations often occur after the biochemical imbalances in the oncogenic process. Therefore, the early cancer-associated metabolic changes are unnoticed by the histopathologist. Additionally, Raman and FTIR spectroscopies significantly reduce the subjectivity linked to cancer diagnosis. This review focuses on breast and head and neck cancers, their clinical needs and the progress made to date using vibrational spectroscopy as a diagnostic technique prior to surgical intervention and intraoperative margin assessment.

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Section: Resultsmentioning

confidence: 99%

A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

Mamede

Santos

Carvalho

et al. 2021

Cancers

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“…Також було показано різницю між спектрами доброякісних і злоякісних клітин молочної залози. При вимірюванні співвідношення відносної інтенсивності різних піків (I1460/I1400 для ліпідних структур, I1460/I1550 для ліпідних структур та I1310/I1240 для білкових структур, I1310/I1240 для нуклеїнових кислот) було встановлено різницю між ліпідним та білковим профілем у здорових та трансформованих клітинах, що дає перспективу використання такої методики для визначення наявності пухлинних процесів на ранніх стадіях та диференціацію клітин пухлини для впровадження персоналізованого лікування [6,7,8,9].…”

Section: статтю підготовлено в межах теми науково-дослідної роботи ка...unclassified

Infrared Spectroscopy and Its Application in Medical and Biological Research

Sheiko,

Kuchmenko,

Havii

et al. 2023

Act. Probl. of the Modern Med.

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Infrared spectroscopy is a spectral research method based on the ability of molecules to absorb infrared radiation with a certain wavelength. Due to the fact that the absorption spectra for different substances are specific and unique, this method is used for the identification of substances, the study of materials, and the study of biomolecules, in particular in the medical field. Infrared spectroscopy serves a multifaceted role in various scientific applications: it is employed to assess the purity and composition of drugs; it enables studying the biochemical makeup of cells of various types, labeling transformed cells, facilitating photodynamic therapy, and exploring the dynamics of in vivo drug release. This method occupies a special place during surgical interventions to identify transformed cells and differentiate them from healthy ones. Thus, during a tumor resection operation, there are risks of excessive or insufficient removal of transformed tissues, which can cause complications, a prolonged period of postoperative intervention, or the absence of remission, in the case of an insufficiently removed tumor. In this case, infrared spectroscopy enables quick and accurate differentiating between healthy and pathological cells, this procedure is fast, accurate, and does not require lengthy sample preparation. Based on the indicators and the ratio of peak intensities, the use of FTIR spectroscopy enables to determine both the qualitative and quantitative composition of proteins and lipids in the transformed cells that can differ and depends on the distance to the tumor. Therefore, in order to introduce and standardize this procedure into surgical interventions and post-operative studies, it is essential to establish comprehensive catalogs of lipidomes and proteomes for various cell types, acquired through the application of infrared spectroscopy.

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“…Some research groups have already shown promising results in which the high sensitivity of this spectroscopic method was detected in the identification and discrimination of various types of cancer at the level of the spectroscopic analysis of tissue samples from organs such as the lungs [85], breast [86] and prostate [87,88]. In fluid analysis, FTIR has been used in the study of the metabolome associated with physiological alterations, revealing a huge potential in the early and minimally invasive diagnosis of several pathologies [89,90].…”

Section: Ftir Spectroscopy and Thyroid Cancermentioning

confidence: 99%

“…Spectral peaks and the corresponding biochemical components and vibrational modes of a typical normal thyroid cytological sample obtained by FNA. Adapted from[47,73,78,86,88,91].…”

mentioning

confidence: 99%

Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review

et al. 2022

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Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy is a metabolomic technique that has already shown promising results in cancer metabolome analysis of neoplastic thyroid tissue, in the identification and classification of prostate tumor tissues and of breast carcinoma, among others. This work aims to gather and discuss published information on the ability of FTIR spectroscopy to be used in metabolomic studies of the thyroid, including discriminating between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors.

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In situ research and diagnosis of breast cancer by using HOF-ATR-FTIR spectroscopy

Cited by 13 publications

References 20 publications

A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

A New Look into Cancer—A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance

Infrared Spectroscopy and Its Application in Medical and Biological Research

Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review

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