In-situ Synthesis and Normal Chromatographic Properties of Nonporous SiO2/ZrO2 Core-shell Composite Microspheres

Li, Jia; Zhang, Hongfei; Shi, Yan‐Ping

doi:10.2116/analsci.27.447

Cited by 9 publications

(14 citation statements)

References 24 publications

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“…The reported surface area (42 m 2 /g) after calcination was much lower than the LbL method, with smaller pores around 32 Å. However, this did not reduce the chromatographic performance of the composite particles .…”

Section: Fabrication Of Core–shell Particles For Separationsmentioning

confidence: 89%

“…Efficient separation and symmetrical peaks were also observed at the other end of pH range when three acidic compounds were analysed (hydroxybenzenes) using ethanol/hexane (25:75) as mobile phase, highlighting the excellent stability across a wide range of pH . Another study reported a column efficiency of 5000 plates/m, short retention time and symmetrical peaks during the separations of neutral compounds, isomers and aromatic compounds using hexane/isopropanol (85:15) as the mobile phase . The column stability was demonstrated at pH 10 using a sodium phosphate solution and a 70:30 methanol/water mobile phase.…”

Section: Applications Of Core–shell Particles With Non‐silica Shellmentioning

confidence: 91%

“…The particles exhibited excellent pH stability at pH 12 after 5000 column volumes . A follow‐up study was reported without the use of surfactant during the synthesis . Electrostatic attachment of positivity charged zirconia nanoparticles onto negatively charged silica particle was achieved by adjusting the pH around 6.…”

Section: Fabrication Of Core–shell Particles For Separationsmentioning

confidence: 99%

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Core–shell microspheres with porous nanostructured shells for liquid chromatography

Ahmed

Skinley

Herodotou

et al. 2017

J of Separation Science

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The development of new stationary phases has been the key aspect for fast and efficient high-performance liquid chromatography separation with relatively low backpressure.Core-shell particles, with a solid core and porous shell, have been extensively investigated and commercially manufactured in the last decade. The excellent performance of core-shell particles columns has been recorded for a wide range of analytes, covering small and large molecules, neutral and ionic (acidic and basic), biomolecules and metabolites. In this review, we first introduce the advance and advantages of coreshell particles (or more widely known as superficially porous particles) against nonporous particles and fully porous particles. This is followed by the detailed description of various methods used to fabricate core-shell particles. We then discuss the applications of common silica core-shell particles (mostly commercially manufactured), spheres-on-sphere particles and core-shell particles with a non-silica shell. This review concludes with a summary and perspective on the development of stationary phase materials for high-performance liquid chromatography applications.

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Section: Fabrication Of Core–shell Particles For Separationsmentioning

confidence: 89%

Section: Applications Of Core–shell Particles With Non‐silica Shellmentioning

confidence: 91%

Section: Fabrication Of Core–shell Particles For Separationsmentioning

confidence: 99%

See 1 more Smart Citation

Core–shell microspheres with porous nanostructured shells for liquid chromatography

Ahmed

Skinley

Herodotou

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

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“…Another advantage of using adsorption is it can allow multiple layers of nanoparticles to be placed onto a support , which can lead to improved retention and resolution . Adsorption through electrostatic interactions has been used for immobilizing materials such as gold nanoparticles , nanomaterials based on zirconia and titanium oxide , and latex nanoparticles onto silica or organic monoliths . A few specific examples are the adsorption of gold nanoparticles onto silica that has been stabilized with L‐cysteine or L‐cysteine methyl ester and the adsorption of zirconia nanoparticles directly, or through alternating layers of these nanoparticles and sodium dodecyl sulfate, on the surface of silica particles .…”

Section: Incorporation or Immobilization Of Nanomaterials In Lc Systemsmentioning

confidence: 99%

“…Nanomaterials have also been utilized in the modes of normal‐phase LC and HILIC . These techniques are both based mainly on the partitioning of analytes into a polar stationary phase, although the exact nature of this phase and of the corresponding mobile phase does differ in these two methods .…”

Section: Nanomaterials In Normal‐phase Lc and Hilicmentioning

confidence: 99%

Nanomaterials as stationary phases and supports in liquid chromatography

et al. 2017

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The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the applications that have been explored for such systems. A number of carbon-based nanomaterials and inorganic nanomaterials have been considered for use in LC, ranging from carbon nanotubes, fullerenes and nanodiamonds to metal nanoparticles and nanostructures based on silica, alumina, zirconia and titanium dioxide. Many ways have been described for incorporating these nanomaterials into LC systems. These methods have included covalent immobilization, adsorption, entrapment, and the synthesis or direct development of nanomaterials as part of a chromatographic support. Nanomaterials have been used in many types of LC. These applications have included the reversed-phase, normal-phase, ion-exchange, and affinity modes of LC, as well as related methods such as chiral separations, ion-pair chromatography and hydrophilic interaction liquid chromatography. Both small and large analytes (e.g., dyes, drugs, amino acids, peptides and proteins) have been used to evaluate possible applications for these nanomaterial-based methods. The use of nanomaterials in columns, capillaries and planar chromatography has been considered as part of these efforts. Potential advantages of nanomaterials in these applications have included their good chemical and physical stabilities, the variety of interactions many nanomaterials can have with analytes, and their unique retention properties in some separation formats.

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Hollow fiber stir bar sorptive extraction for determination of phthalic acid esters in environmental and biological matrices

Wang

et al. 2017

J of Separation Science

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The purpose of this paper is to introduce a novel hollow fiber stir bar sorptive extraction for collecting and determining of phthalic acid esters in environmental and biological matrices. Shell-core ZrO /SiO composite microspheres and porous C silica microspheres were compared as the sorbents, which were loaded in the lumen of a microporous hollow fiber membrane. A thin stainless-steel wire was also inside of the hollow fiber membrane acting as the magnetic stirrer, thus affording the procedures like stir bar sorptive extraction to perform the active trapping of the analytes. Variables affecting the extraction (salt addition and pH of samples, extraction temperature, and time) and desorption (microwave time and eluted solvents) have been optimized. Under the optimal conditions, good linearity (r > 0.9968) of all calibration curves was obtained in validation experiments. And the limits of quantification ranged from 0.01 to 1000 ng/mL. The recoveries in different matrices were in the range of 64.90-112.60% with relative standard deviations less than 8.60%. The present work demonstrated the applicability of the developed method for the determination of phthalic acid esters in environmental and biological sample, allowing the selective extraction of phthalate esters in complex samples with low consumption of organic solvents and no sample clean-up.

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In-situ Synthesis and Normal Chromatographic Properties of Nonporous SiO2/ZrO2 Core-shell Composite Microspheres

Cited by 9 publications

References 24 publications

Core–shell microspheres with porous nanostructured shells for liquid chromatography

Core–shell microspheres with porous nanostructured shells for liquid chromatography

Nanomaterials as stationary phases and supports in liquid chromatography

Hollow fiber stir bar sorptive extraction for determination of phthalic acid esters in environmental and biological matrices

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