In situ synthesis of fluorescent silicon nanodots for determination of total carbohydrates in a paper microfluidic device combined with laser prepared graphene heater

Ortiz-Gómez, Inmaculada; Toral, Víctor; Romero, Francisco J.; Orbe-Payá, Ignacio de; García, Antonio; Rodríguez, Noel; Capitán-Vallvey, L.F.; Morales, Diego P.; Salinas-Castillo, Alfonso

doi:10.1016/j.snb.2021.129506

Cited by 23 publications

(14 citation statements)

References 40 publications

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“…Si QDs are synthesized facilely according to previous literature. [24,30] Simply, glucose served as reductant is mixed with 3-aminopropyltriethoxysilane (3-APTES) for aqueous Si QDs preparation at room temperature. Then, the as-prepared Si QDs are transferred into CNCs solution.…”

Section: Resultsmentioning

confidence: 99%

Circularly Polarized Light Source from Self‐Assembled Hybrid Nanoarchitecture

Wang

Zhang

et al. 2022

Advanced Optical Materials

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chirality-based light emitting diodes (LEDs), [7,8] and so forth. [9,10] Extensive efforts have been applied to a broad range of organic luminophores up till now. [11] However, only a few CPL-active inorganic nanomaterials have been designed recently due to the complexity of fine controlled chiroptical responses and insufficient theoretical background explaining the origin of chirality. [12,13] Various approaches have been developed to realize CPL from inorganic nanomaterials. For instance, nanocrystals could exhibit CPL behaviors through the π conjugated interaction between chiral capping ligand and achiral cores. [12,14] It is also hypothesized that chiral environment could confer CPL on quantum dots (QDs), which has been evidenced by CdS QDs encapsulated in chiral apoferritin. [15] However, these approaches usually need tedious synthesis procedures, and the induced CPL signal is usually very low with the dissymmetry factor only ≈10 −3 -10 −4 . [12][13][14][15][16] Moreover, it is known that most metal-based nanomaterials are toxic and have the disadvantage of high manufacturing cost, which limit their widespread applications. Under this circumstance, it is urgent to develop environmentally friendly and CPL nanomaterials with high strength and capacity for scalable preparations.Silicon-based nanoparticles have gained extensive attentions owing to their desirable properties such as being comprised of earth-abundant elements, favorable biocompatibility, and excellent photostability. [17][18][19] Fluorescent silicon QDs (Si QDs) have been recognized as a promising material sharing remarkable optical and electronic properties of traditional metal-based semiconductor QDs. In the past decades, considerable efforts have been devoted to investigate their synthetic strategies and practical applications. A variety of green and simple synthetic methods have been developed for preparing this promising material. [17,[20][21][22] Besides, the excellent water stability, high fluorescence, and low toxicity make them suitable for applications in plenty of fields such as bioimaging, photocatalysis, and sensing. [23][24][25] Based on these outstanding properties, Si QDs is undoubtedly a prominent candidate for the implementation of CPL. To the best of our knowledge, conferring CPL on Si QDs has not been reported to date.Cellulose nanocrystals (CNCs) are renewable and biocompatible nanomaterials which could be easily obtained from bulk cellulose by acid-hydrolysis. After treating with sulfuric acid, CNCs could exhibit excellent water dispersibility due to negative charge from the enriched sulfonate groups on the surfaces. [26,27] Circularly polarized luminescent inorganics arouses attentions due to scalable preparation and versatile chiral optoelectronic applications. Here, strong circularly polarized luminescence (CPL) activity has been developed from self-assembled cellulose nanocrystals decorated with blue emitting silicon quantum dots (QDs). The electrostatic attraction promotes the successful incorporation of QDs into chiral ...

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Section: Resultsmentioning

confidence: 99%

Circularly Polarized Light Source from Self‐Assembled Hybrid Nanoarchitecture

Wang

Zhang

et al. 2022

Advanced Optical Materials

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“…Microfluidics has proven to be a valuable tool for analyzing different types of metabolites, offering fast assay times, portability, low cost, and sample consumption [43]. The list of microfluidics systems employed for metabolite detection includes paperbased devices [115][116][117][118][119][120][121][122][123][124][125][126][127][128], microfluidic droplets [129][130][131][132][133][134], microchannels or microchambers made of polydimethylsiloxane (PDMS) [135][136][137][138][139][140][141][142], or centrifugal microfluidic platforms [143][144][145][146]. Detection methods commonly used for these systems consist of colorimetry [116-118, 120, 121, 123, 131, 133, 143, 147, 148], fluorescence [122,136,145,149], chemiluminescence [145], electrochemistry [115, 119, 127-129, 135, 137, 142], MS [130,134,150,151], or surface plasmo...…”

Section: Metabolite Biomarkersmentioning

confidence: 99%

“…The list of microfluidics systems employed for metabolite detection includes paper‐based devices [115–128], microfluidic droplets [129–134], microchannels or microchambers made of polydimethylsiloxane (PDMS) [135–142], or centrifugal microfluidic platforms [143–146]. Detection methods commonly used for these systems consist of colorimetry [116–118, 120, 121, 123, 131, 133, 143, 147, 148], fluorescence [122, 136, 145, 149], chemiluminescence [145], electrochemistry [115, 119, 127–129, 135, 137, 142], MS [130, 134, 150, 151], or surface plasmon resonance (SPR) [152] (Figure 2). Some of these microfluidic platforms integrate sample preparation and are readily incorporated into portable instruments to automate their operation [143].…”

Section: Metabolite Biomarkersmentioning

confidence: 99%

Microfluidic systems for the analysis of blood‐derived molecular biomarkers

Chavez-Pineda¹,

Rodriguez‐Moncayo²,

Cedillo-Alcantar³

et al. 2022

Electrophoresis

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Biomarkers are relevant indicators of the physiological state of an individual.Although biomarkers can be found in diseased tissue and different biofluids, sampling from blood plasma is relatively easy and less invasive. Among the molecular biomarkers that can be found circulating in plasma are proteins, metabolites, nucleic acids, and exosomes. Some of these plasma-circulating biomarkers are now employed for patient stratification in a broad range of diseases with high sensitivity and specificity and are useful in early diagnosis, initial risk assessment, and therapy selection. However, there is a pressing need to develop novel approaches for biomarker analysis that can be translated into clinical or other settings without complex methodologies or instrumentation. Microfluidics has been touted as a promising technology to carry out this task because it offers high-throughput, automation, multiplexed detection, and portability, possibly overcoming the bottleneck that prevent the translation of novel biomarkers to the point-of-care (POC). Here, we provide a review of the microfluidic systems that have been engineered to detect circulating molecular biomarkers in blood plasma. We also review the different microfluidic approaches for plasma enrichment, which are now being integrated with microfluidic-based biomarker analyzers. Such integration should lead to

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“…Laser printed graphene is also of great utility in a number of biosensor applications. For instance, Ortiz-Gómez et al ablated a PI film with a 12 W CO 2 laser operating at 2.4 W and 0.15 m/s to create a graphene heater for a microfluidic device that used fluorescent silicon nanodots to detect total carbohydrates [ 125 ]. In addition, GO can be reduced by laser excitation through the conversion of sp 3 carbon to sp 2 and the removal of oxygen functional groups, and the photothermal and photochemical processes involved in the reduction of GO can be well controlled by altering the laser wavelength [ 126 ].…”

Section: Conductive Nanomaterials Printingmentioning

confidence: 99%

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

2021

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Hybrid flexible bioelectronic systems refer to integrated soft biosensing platforms with tremendous clinical impact. In this new paradigm, electrical systems can stretch and deform with the skin while previously hidden physiological signals can be continuously recorded. However, hybrid flexible bioelectronics will not receive wide clinical adoption until these systems can be manufactured at industrial scales cost-effectively. Therefore, new manufacturing approaches must be discovered and studied under the same innovative spirit that led to the adoption of novel materials and soft structures. Recent works have taken mature manufacturing approaches from the graphics industry, such as gravure, flexography, screen, and inkjet printing, and applied them to fully printed bioelectronics. These applications require the cohesive study of many disparate parts. For instance, nanomaterials with optimal properties for each specific application must be dispersed in printable inks with rheology suited to each printing method. This review summarizes recent advances in printing technologies, key nanomaterials, and applications of the manufactured hybrid bioelectronics. We also discuss the existing challenges of the available nanomanufacturing methods and the areas that need immediate technological improvements.

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In situ synthesis of fluorescent silicon nanodots for determination of total carbohydrates in a paper microfluidic device combined with laser prepared graphene heater

Cited by 23 publications

References 40 publications

Circularly Polarized Light Source from Self‐Assembled Hybrid Nanoarchitecture

Circularly Polarized Light Source from Self‐Assembled Hybrid Nanoarchitecture

Microfluidic systems for the analysis of blood‐derived molecular biomarkers

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

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