In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

Abstract

Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.

Silver Nanoparticles-Composing Alginate/Gelatine Hydrogel Improves Wound Healing In Vivo

“…The nanoparticle absorption spectra of this analysis showed a maximum band around 430-450 nm suggesting a spheroidal form. Other researchers developed hydrogel with natural polymer incorporating AgNPs and obtained similar results [34,35].…”

“…The nanoparticle absorption spectra of this analysis showed a maximum band around 430-450 nm suggesting a spheroidal form. Other researchers developed hydrogel with natural polymer incorporating AgNPs and obtained similar results [34,35]. FT-IR was used to identify the characteristic bands of the present groups and to observe the possible interaction between the functional groups of the molecules composing the formulation.…”

Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

“…Among the natural polymers, cellulose is much more preferred for modification and use because of its low cost, abundance, and intermolecular hydrogen bond patterns that form mechanically stable fibers [13]. Carboxymethyl cellulose (CMC), a common semisynthetic natural polymer derived from cellulose, shows promising applications for biological and biomedical engineering, including drug delivery [14][15][16], wound healing [17,18], bone tissue engineering [19,20], and biosensing [21]. Crosslinking CMC with polyethylene glycol diglycidyl ether (PEGDE) helps to increase the physical strength of the hydrogels and achieves good adsorption abilities toward lysozyme [22], which would be expected to be a drug carrier for protein drugs.…”

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

“…244 More examples on this nanoparticle are available in Table 1. [245][246][247][248][249] Biopolymer Drug Conjugate (BDC) Thermally sensitive biopolymer with the potential ability to quickly form insoluble viscous co-acervate at body temperature can be used for this purpose (Figure 18). 250,251 Although some of the biomedical polymer-drug conjugates are approved for clinical trials, they lack photothermal properties and multi-imaging capabilities, impeding them from imaging-guided precision cancer therapy and total cancer arrested development.…”